Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alan Aitchison"'
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Background Carriage of certain bacterial species may represent potential biomarkers of colorectal cancer (CRC). Prominent among these is Fusobacterium nucleatum. We explored the association of F. nucleatum DNA in stool samples with the presence of co
Externí odkaz:
https://doaj.org/article/41a28ce5040844f8834f90bd617b3c6a
Publikováno v:
Journal of Functional Foods, Vol 28, Iss , Pp 293-298 (2017)
Clinically, there is a growing need to identify new means to limit the response of the gut mucosa to inflammatory stimuli. Bovine colostrum is increasingly recognised to promote human gastrointestinal health but the mechanism(s) involved are not enti
Externí odkaz:
https://doaj.org/article/1e54749af8d6427d8b3bae395174d8c5
Autor:
Alan Aitchison, Christopher Hakkaart, Robert C. Day, Helen R. Morrin, Frank A. Frizelle, Jacqueline I. Keenan
Publikováno v:
Cancers, Vol 12, Iss 12, p 3829 (2020)
While overall colorectal cancer (CRC) cases have been declining worldwide there has been an increase in the incidence of the disease among patients under 50 years of age. Mutation of the APC gene is a common early event in CRC but is reported at lowe
Externí odkaz:
https://doaj.org/article/a4f045485da24cd18086a1661038f4bd
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184026 (2017)
The iron deficiency anaemia that often accompanies infection with Helicobacter pylori may reflect increased uptake of iron into gastric epithelial cells. Here we show an infection-associated increase in total intracellular iron levels was associated
Externí odkaz:
https://doaj.org/article/e32a9041dff646d0a064d232f7694f33
Autor:
Rachel V Purcell, John Pearson, Alan Aitchison, Liane Dixon, Frank A Frizelle, Jacqueline I Keenan
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171602 (2017)
BACKGROUND:Enterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by modulating the mucosal immune response and inducing epithelial cell changes. Here, we aim to examine the ass
Externí odkaz:
https://doaj.org/article/cfc7ae0a87984cd08fb3e2c85159717c
Autor:
Aaron J Stevens, Selma Stuffrein-Roberts, Simone L Cree, Andrew Gibb, Allison L Miller, Kit Doudney, Alan Aitchison, Michael R Eccles, Peter R Joyce, Vyacheslav V Filichev, Martin A Kennedy
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113955 (2014)
We observed apparent non-Mendelian behaviour of alleles when genotyping a region in a CpG island at the 5' end of the maternally imprinted human MEST isoform. This region contains three single nucleotide polymorphisms (SNPs) in total linkage disequil
Externí odkaz:
https://doaj.org/article/52785fa2003c4c32bc56e267039734bf
Publikováno v:
New Zealand Veterinary Journal. 67:329-332
Aims: To determine if presence of the Bacteroides fragilis toxin (bft) gene, a molecular marker of colonic carriage of entertoxigenic Bacteroides fragilis (ETBF) in humans, was associated with a fi...
Autor:
Robert C. Day, Christopher Hakkaart, Jacqueline I. Keenan, Frank A. Frizelle, Alan Aitchison, Helen Morrin
Publikováno v:
Cancers
Volume 12
Issue 12
Cancers, Vol 12, Iss 3829, p 3829 (2020)
Volume 12
Issue 12
Cancers, Vol 12, Iss 3829, p 3829 (2020)
Simple Summary Mutation of the APC gene is a common early event in colorectal cancer, however lower rates have been reported in younger cohorts of colorectal cancer patients. In sporadic cancer, mutations are typically clustered around a mutation clu
Autor:
Rashida Ahmed, Martin Whitehead, Alan Aitchison, Frank A. Frizelle, Jacqueline I. Keenan, Sadaf Khan, Christopher Hakkaart, Sabeehuddin Siddique
Publikováno v:
Pathology, research and practice. 216(5)
Aim Colorectal signet-ring cell carcinomas (SRCC) are highly malignant tumours with poor prognosis that disproportionately affect younger patients. There is growing evidence of a unique set of molecular features that separate SRCC from conventional c
Publikováno v:
Journal of Functional Foods, Vol 28, Iss, Pp 293-298 (2017)
Clinically, there is a growing need to identify new means to limit the response of the gut mucosa to inflammatory stimuli. Bovine colostrum is increasingly recognised to promote human gastrointestinal health but the mechanism(s) involved are not enti