Zobrazeno 1 - 10
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pro vyhledávání: '"Alan A. Jones"'
Autor:
Hasan Yousaf, Alan M. Jones
Publikováno v:
Pharmacoepidemiology, Vol 3, Iss 3, Pp 241-251 (2024)
Aims: The aim of this study was to explore the suspected adverse drug reaction (ADR) data of five licensed statins in the UK: atorvastatin, fluvastatin, pravastatin, rosuvastatin, and simvastatin. A secondary aim was to determine if there are any ass
Externí odkaz:
https://doaj.org/article/1990f4e8eec84f85969151888795bd1d
Autor:
Ridho Asra, Alan M. Jones
Publikováno v:
ChemElectroChem, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract The development of electrochemical approaches to the valorization of abundant natural products into high value medications and metabolites is of pharmaceutical interest. In this study, we explored the electrosynthetic behavior of the abundan
Externí odkaz:
https://doaj.org/article/9a8e857f2d45449ea70cefe6e1363704
Autor:
Sadettin Y. Ugurlu, David McDonald, Huangshu Lei, Alan M. Jones, Shu Li, Henry Y. Tong, Mark S. Butler, Shan He
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Probing the surface of proteins to predict the binding site and binding affinity for a given small molecule is a critical but challenging task in drug discovery. Blind docking addresses this issue by performing docking on binding regions ran
Externí odkaz:
https://doaj.org/article/001a3fa967f9469b8b1c42f848bc17ec
Publikováno v:
Molecules, Vol 29, Iss 13, p 3038 (2024)
The tractable preparation of Phase I drug metabolites is a critical step to understand the first-pass behaviour of novel chemical entities (NCEs) in drug discovery. In this study, we have developed a structure–electroactivity relationship (SeAR)-in
Externí odkaz:
https://doaj.org/article/88b96f4184854f24b06da0165f0b0495
Publikováno v:
Molecules, Vol 29, Iss 10, p 2406 (2024)
In this article, we introduce a proof-of-concept strategy, Computational Predictive and Electrochemical Detection of Metabolites (CP-EDM), to expedite the discovery of drug metabolites. The use of a bioactive natural product, piperine, that has a wel
Externí odkaz:
https://doaj.org/article/2dbdf06f9a54443fb7f7feee40c4d574
Autor:
Yifei Zhou, Alan M. Jones
Publikováno v:
Molecules, Vol 29, Iss 7, p 1667 (2024)
The Beckmann rearrangement of ketoximes to their corresponding amides, using a Brønsted acid-mediated fragmentation and migration sequence, has found wide-spread industrial application. We postulated that the development of a methodology to access y
Externí odkaz:
https://doaj.org/article/b74f481c6b64446995b7d28d7d58f2d9
Autor:
Alexander M. Kaizer, Nathan I. Shapiro, Jessica Wild, Samuel M. Brown, B. Jessica Cwik, Kimberly W. Hart, Alan E. Jones, Michael S. Pulia, Wesley H. Self, Clay Smith, Stephanie A. Smith, Patrick C. Ng, B. Taylor Thompson, Todd W. Rice, Christopher J. Lindsell, Adit A. Ginde
Publikováno v:
International Journal of Infectious Diseases, Vol 128, Iss , Pp 223-229 (2023)
Objectives: Effective and widely available therapies are still needed for outpatients with COVID-19. We aimed to evaluate the efficacy and safety of lopinavir/ritonavir (LPV/r) for early treatment of non-hospitalized individuals diagnosed with COVID-
Externí odkaz:
https://doaj.org/article/a331a0a5b9994c778243d39b26885423
Autor:
Akshaya Kumar Biswal, Amos Emitati Alakonya, Khondokar Abdul Mottaleb, Sarah J. Hearne, Kai Sonder, Terence Luke Molnar, Alan M. Jones, Kevin Vail Pixley, Boddupalli Maruthi Prasanna
Publikováno v:
BMC Plant Biology, Vol 22, Iss 1, Pp 1-21 (2022)
Abstract Background Maize lethal necrosis (MLN) disease is a significant constraint for maize producers in sub-Saharan Africa (SSA). The disease decimates the maize crop, in some cases, causing total crop failure with far-reaching impacts on regional
Externí odkaz:
https://doaj.org/article/72ff08d5c6b441f98d5f218f564d6d50
Autor:
Yifei Zhou, Alan M. Jones
Publikováno v:
Molecules, Vol 29, Iss 7, p 1445 (2024)
The C(sp2)-aryl sulfonate functional group is found in bioactive molecules, but their synthesis can involve extreme temperatures (>190 °C or flash vacuum pyrolysis) and strongly acidic reaction conditions. Inspired by the 1917 Tyrer industrial proce
Externí odkaz:
https://doaj.org/article/058b3fab498c4e5eb5550603b784702d
Autor:
Gary P. Sidgwick, Ria Weston, Ayman M. Mahmoud, Andrew Schiro, Ferdinand Serracino-Inglott, Shikha M. Tandel, Sarah Skeoch, Ian N. Bruce, Alan M. Jones, M. Yvonne Alexander, Fiona L. Wilkinson
Publikováno v:
Cells, Vol 13, Iss 4, p 312 (2024)
Heparan sulphate (HS) can act as a co-receptor on the cell surface and alterations in this process underpin many pathological conditions. We have previously described the usefulness of mimics of HS (glycomimetics) in protection against β-glycerophos
Externí odkaz:
https://doaj.org/article/23fe648e87074950baf042e9c80d7f74