Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alan A Ly"'
Autor:
Shilong Yang, Xinwen Miao, Steven Arnold, Boxuan Li, Alan T. Ly, Huan Wang, Matthew Wang, Xiangfu Guo, Medha M. Pathak, Wenting Zhao, Charles D. Cox, Zheng Shi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
This study demonstrates that the curvature of the cell membrane directly regulates the spatial distribution of Piezo1, a widely expressed mechanosensitive ion channel. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics
Externí odkaz:
https://doaj.org/article/7c6e40022e03487d9d2a0edfa393acce
Autor:
Shilong Yang, Xinwen Miao, Steven Arnold, Boxuan Li, Alan T. Ly, Huan Wang, Matthew Wang, Xiangfu Guo, Medha M. Pathak, Wenting Zhao, Charles D. Cox, Zheng Shi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f8d7dd5290874c39834e2311f172d935
Autor:
Anna M Prince, Louise A Prince, Paul F Klawitter, Elizabeth Nicholas, Alan A Ly, Kevin Gaskin
Publikováno v:
Journal of Ultrasound in Medicine. 40:2459-2465
Objectives Ultrasound is used by nearly every medical specialty. Medical schools are integrating ultrasound education into their curriculum but studies show this to be inconsistent. The purpose of this study was to provide an updated description of u
Autor:
Vivek Tyagi, Alan T. Ly, Gabriella A. Bertaccini, Elizabeth L. Evans, J. Alfredo Freites, Douglas J. Tobias, Medha M. Pathak
Publikováno v:
Biophysical Journal. 122:90a
The mechanically-activated ion channel Piezo1 is involved in numerous physiological processes. Piezo1 is activated by diverse mechanical cues and is gated by membrane tension. The channel has been found to be mobile in the plasma membrane. We employe
Autor:
Shilong Yang, Xinwen Miao, Steven Arnold, Boxuan Li, Alan T. Ly, Huan Wang, Matthew Wang, Xiangfu Guo, Medha M. Pathak, Wenting Zhao, Charles D. Cox, Zheng Shi
Publikováno v:
Nature communications, vol 13, iss 1
Piezo1 is abona fidemechanosensitive ion channel ubiquitously expressed in mammalian cells. The distribution of Piezo1 within a cell is essential for various biological processes including cytokinesis, cell migration, and wound healing. However, the
Autor:
Jamison L. Nourse, Vivian M. Leung, Hamid Abuwarda, Elizabeth L. Evans, Esmeralda Izquierdo-Ortiz, Alan T. Ly, Nguyen Truong, Samantha Smith, Harsh Bhavsar, Gabriella Bertaccini, Edwin S. Monuki, Mitradas M. Panicker, Medha M. Pathak
Publikováno v:
The Journal of general physiology. 154(10)
Mechanical forces and tissue mechanics influence the morphology of the developing brain, but the underlying molecular mechanisms have been elusive. Here, we examine the role of mechanotransduction in brain development by focusing on Piezo1, a mechani
Autor:
Boris Brumshtein, Shannon R Esswein, Lukasz Salwinski, Martin L Phillips, Alan T Ly, Duilio Cascio, Michael R Sawaya, David S Eisenberg
Publikováno v:
eLife, Vol 4 (2015)
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which
Externí odkaz:
https://doaj.org/article/13c7f8e63ae14a8ebae1d9de36a40291
Autor:
Gregory M. Rosenberg, Shannon R. Esswein, Boris Brumshtein, Meytal Landau, David Eisenberg, Michael R. Sawaya, Alan T Ly
Publikováno v:
The Journal of biological chemistry, vol 293, iss 51
Systemic light-chain amyloidosis (AL) is a human disease caused by overexpression of monoclonal immunoglobulin light chains that form pathogenic amyloid fibrils. These amyloid fibrils deposit in tissues and cause organ failure. Proteins form amyloid
Autor:
Alan T. Ly, Vivek Tyagi, Gabriella A. Bertaccini, Elizabeth L. Evans, J. Alfredo Freites, Douglas J. Tobias, Medha M. Pathak
Publikováno v:
Biophysical Journal. 121:436a
The bacterial copper resistance protein CopG contains a cysteine-bridged tetranuclear copper cluster
Publikováno v:
J Biol Chem
The Journal of biological chemistry, vol 295, iss 32
The Journal of biological chemistry, vol 295, iss 32
CopG is an uncharacterized protein ubiquitous in Gram-negative bacteria whose gene frequently occurs in clusters of copper resistance genes and can be recognized by the presence of a conserved CxCC motif. To investigate its contribution to copper res