Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Alan Kosaka"'
Autor:
Xiaochuan Shan, Juan José Fung, Alan Kosaka, Gwenn Danet-Desnoyers, Reproducibility Project: Cancer Biology
Publikováno v:
eLife, Vol 7 (2018)
Externí odkaz:
https://doaj.org/article/e50a089523e14aa2b486a131697a6ef7
Autor:
Xiaochuan Shan, Juan Jose Fung, Alan Kosaka, Gwenn Danet-Desnoyers, Reproducibility Project: Cancer Biology
Publikováno v:
eLife, Vol 6 (2017)
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Fung et al., 2015), that described how we intended to replicate selected experiments from the paper "Inhibition of BET recruitment to chromatin as an e
Externí odkaz:
https://doaj.org/article/0562aca1f4cf4500853d57ffff6a6d71
Autor:
Juan José Fung, Alan Kosaka, Xiaochuan Shan, Gwenn Danet-Desnoyers, Michael Gormally, Kate Owen, Reproducibility Project: Cancer Biology
Publikováno v:
eLife, Vol 4 (2015)
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The pap
Externí odkaz:
https://doaj.org/article/4d0c8be0eaf9468bb6f9d45c14d1e5eb
Autor:
Alicja J Copik, Aleksander Baldys, Khanh Nguyen, Sunil Sahdeo, Hoangdung Ho, Alan Kosaka, Paul J Dietrich, Bill Fitch, John R Raymond, Anthony P D W Ford, Donald Button, Marcos E Milla
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0115701 (2015)
The α1A-AR is thought to couple predominantly to the Gαq/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to trigger activation of arachidonic acid fo
Externí odkaz:
https://doaj.org/article/f47f66804c3a42b0a43ac356b5af6f80
Autor:
Yong Huang, Kathleen M. Giacomini, Arik A. Zur, Natalia Khuri, Yasuto Kido, Alan Kosaka, Xuexiang Zhang, Kari M. Morrissey, Matthias B. Wittwer, Andrej Sali
Publikováno v:
Journal of medicinal chemistry, vol 56, iss 3
The human multidrug and toxin extrusion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs. Inhibition of MATE1 may result in potential drug-drug interactions (DDIs) and alterations in drug exposure and accumulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108b4ff04ff24d299ab4ee76dece7176
https://doi.org/10.1021/jm301302s
https://doi.org/10.1021/jm301302s
Autor:
Alan Kosaka, Hyunsoon Kang, Abel De La Rosa, Aren Ewing, M.M. Berrey, Nick Cammack, Isabel Najera, A. Seshaadri, J.M. Yan, Bill Symonds, Sophie Le Pogam
Publikováno v:
The Journal of Infectious Diseases. 202:1510-1519
Introduction. RG7128 (prodrug of PSI-6130) shows potent antiviral efficacy in patients infected with hepatitis C virus (HCV) genotypes 1, 2, or 3, with mean viral load decreases of 2.7 and 5 log 10 IU/mL, respectively, associated with 1500-mg doses t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e3179c9fb4f6d9d8af2c825023ff74
https://doi.org/10.1086/656774
https://doi.org/10.1086/656774
Autor:
Steven Hu, Hyunsoon Kang, Sophie Le Pogam, Isabel Najera, Sonal Rajyaguru, Nick Cammack, A. Seshaadri, Sophie Chiu, Alan Kosaka, Julian Symons
Publikováno v:
Journal of Antimicrobial Chemotherapy. 61:1205-1216
To characterize the effect of hepatitis C virus (HCV) polymerase intrinsic genetic heterogeneity on the inhibitory activity of nucleoside and non-nucleoside HCV polymerase inhibitors.The sensitivity of genotype (GT) 1 HCV NS5B clinical isolates from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a4a05531cc418b2ee2f29824b8e329
https://doi.org/10.1093/jac/dkn085
https://doi.org/10.1093/jac/dkn085
Autor:
Khanh Nguyen, Hoangdung Ho, Anthony P.D.W. Ford, Sunil Sahdeo, Donald Button, Aleksander Baldys, Marcos E. Milla, Alicja J. Copik, Alan Kosaka, John R. Raymond, Bill Fitch, Paul J. Dietrich
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0115701 (2015)
PLoS ONE
PLoS ONE
The α1A-AR is thought to couple predominantly to the Gαq/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to trigger activation of arachidonic acid fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea26fba5a92303d57dfbe05ee49d3b7
http://europepmc.org/articles/PMC4301629?pdf=render
http://europepmc.org/articles/PMC4301629?pdf=render
Publikováno v:
European Journal of Pharmacology. 504:155-167
The objective of this study was to pharmacologically characterize bradykinin receptors, a component of the kallikrein-kinin system, in normal human prostate cells. In primary cultured human prostate stromal cells, bradykinin, but not [des-Arg9]bradyk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5989f9c317f0300dfe70da24b7ff4e
https://doi.org/10.1016/j.ejphar.2004.10.004
https://doi.org/10.1016/j.ejphar.2004.10.004