Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alan F. Gasiecki"'
Autor:
Samuel J. Tremont, Rick L. Fenton, Alan F. Gasiecki, William E. Perkins, Peter H. Jones, Paul W. Collins, Denis Forster, Grace M. Wagner, Martin P. Mcgrath
Publikováno v:
Catalysis of Organic Reactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b7d8aca6d9db697d10afd6b25203de
https://doi.org/10.1201/9781315138855-21
https://doi.org/10.1201/9781315138855-21
Autor:
Alan F. Gasiecki, Douglas Kalvin, Eric F. Johnson, Irini Akritopoulou-Zanze, Stevan W. Djuric, Brian D. Wakefield, Peter Kovar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1480-1483
We report the synthesis and biological evaluation of 5-substituted indazoles as kinase inhibitors. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing heterocycle forming and multicompone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7b2b0181113f35782edd76d1263a2b
https://doi.org/10.1016/j.bmcl.2011.01.001
https://doi.org/10.1016/j.bmcl.2011.01.001
Autor:
Srinivasan Nagarajan, Ish K. Libertyville Khanna, Tiffany Duffin, Alan F. Gasiecki, Jeffery L. Keene, Mihir D. Parikh, Michael Clare, Marisa M. Westlin, Maureen A. Nickols, Christina A. Steininger, Melanie L. Williams, Hwang-Fun Lu, Thomas Rogers, Jon A. Klover, Mary Beth Finn, V. Wayne Engleman, Sandra K. Freeman, William F. Westlin, Barbara B. Chen, G. Alan Nickols, Kristen E. Shannon, Mark A. Russell, Bipinchandra N. Desai
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3390-3412
The integrin alpha(v)beta(3) is expressed in a number of cell types and is thought to play a major role in several pathological conditions. Various small molecules that inhibit the integrin have been shown to suppress tumor growth and retinal angioge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76977820b693cad5d5c26a6da2d6f596
https://doi.org/10.1016/j.bmc.2007.03.020
https://doi.org/10.1016/j.bmc.2007.03.020
Autor:
Peter F. Bousquet, Daniel H. Albert, Gary A. Gintant, Patrick A. Marcotte, Gilbert Diaz, George A. Cunha, Ruth L. Martin, Kathryn Houseman, Stevan W. Djuric, Jürgen Dinges, Jennifer J. Bouska, Thomas J. Sowin, Paul Tapang, Charles W. Hutchins, Michael R. Michaelides, Kimba L. Ashworth, Eric F. Johnson, Henry Q. Zhang, Irini Akritopoulou-Zanze, Michelle Nyein, Arnold Lee D, Hu Li, Steven K. Davidsen, Alan F. Gasiecki, Christopher M. Harris, Vijaya Gracias, Zhi Su, Zhiren Xia
Publikováno v:
Journal of Medicinal Chemistry. 50:2011-2029
The synthesis of a novel series of 1,4-dihydroindeno[1,2-c]pyrazoles with acetylene-type side chains is described. Optimization of those compounds as KDR kinase inhibitors identified 8, which displayed an oral activity in an estradiol-induced murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7224e585fce7d1645dd21a1f5e3e55
https://doi.org/10.1021/jm061223o
https://doi.org/10.1021/jm061223o
Publikováno v:
Tetrahedron Letters. 47:8873-8876
A concise route to access fused imidazole rings employing the van Leusen three-component reaction followed by a Pd/Cu catalyzed intramolecular C-arylation is reported. The reaction was found to be general and the products were formed in moderate to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5654e6f664aaa720ae0e29145238f37
https://doi.org/10.1016/j.tetlet.2006.10.051
https://doi.org/10.1016/j.tetlet.2006.10.051
Publikováno v:
Tetrahedron Letters. 46:9049-9052
A facile synthesis of fused imidazo azepine derivatives by a van Leusen/intramolecular enyne metathesis synthetic sequence is reported. The two-step reaction sequence generates compounds of significant molecular complexity from simple starting materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70013c027474aac92f8eef6f6395c3ed
https://doi.org/10.1016/j.tetlet.2005.10.089
https://doi.org/10.1016/j.tetlet.2005.10.089
Publikováno v:
Organic Letters. 7:3183-3186
[reaction: see text]. A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9499de620825fdeb40aaecb04c44292
https://doi.org/10.1021/ol050852+
https://doi.org/10.1021/ol050852+
Autor:
Thomas D. Penning, Nizal S. Chandrakumar, Barbara B. Chen, Helen Y. Chen, Bipin N. Desai, Stevan W. Djuric, Stephen H. Docter, Alan F. Gasiecki, Richard A. Haack, Julie M. Miyashiro, Mark A. Russell, Stella S. Yu, David G. Corley, Richard C. Durley, Brian F. Kilpatrick, Barry L. Parnas, Leslie J. Askonas, James K. Gierse, Elizabeth I. Harding, Maureen K. Highkin, James F. Kachur, Suzanne H. Kim, Gwen G. Krivi, Doreen Villani-Price, E. Yvonne Pyla, Walter G. Smith, Nayereh S. Ghoreishi-Haack
Publikováno v:
Journal of Medicinal Chemistry. 43:721-735
Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. Since the action of LTA(4) hydrolase is the rate-limiting step for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2c8b8f857645ec82bda0e73ed60429
https://doi.org/10.1021/jm990496z
https://doi.org/10.1021/jm990496z
Publikováno v:
Tetrahedron Letters. 49:6286-6288
The Ollis–Sweeney ammonium ylid rearrangement has been effectively utilized to provide access to hitherto unknown hybrid privileged structural motifs. The rearrangement of didehydropiperidinium salts containing tethered olefins at the 4-position af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97eefeb32a6ffd49a4c804d57c95e1ca
https://doi.org/10.1016/j.tetlet.2008.08.055
https://doi.org/10.1016/j.tetlet.2008.08.055
Autor:
Doreen Villani-Price, Suzanne H Kim, Walter G. Smith, Leslie J Askonas, Elizabeth I Harding, Maureen K Highkin, Thomas D. Penning, Alan F. Gasiecki, Nayereh S Ghoreishi-Haack, Nizal S Chandrakumar, E.Yvonne Pyla, Bipin N Desai, James F Kachur, Mark A Russell, Stevan W Djuric, James W. Malecha, James K. Gierse, Julie M Miyashiro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1137-1139
The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830ee52b64cb2d30d9d134d0185d9a9
https://doi.org/10.1016/s0960-894x(03)00039-8
https://doi.org/10.1016/s0960-894x(03)00039-8