Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alan, Sarup"'
Publikováno v:
European Journal of Pharmacology. 500:281-287
Inactivation of gamma-aminobutric acid (GABA) as a neurotransmitter is mediated by diffusion in the synaptic cleft followed by binding to transporter sites and translocation into the intracellular compartment. The GABA transporters of which four subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5dee7df8310e101a5ee7f4ea616bf3
https://doi.org/10.1016/j.ejphar.2004.07.032
https://doi.org/10.1016/j.ejphar.2004.07.032
Publikováno v:
Biochemical Pharmacology. 68:1557-1563
The identification and subsequent development of the GABA transport inhibitor tiagabine has confirmed the important role that GABA transporters play in the control of CNS excitability. Tiagabine was later demonstrated to be a selective inhibitor of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f6505788b93bb0a717ddd07fb32710
https://doi.org/10.1016/j.bcp.2004.06.041
https://doi.org/10.1016/j.bcp.2004.06.041
Publikováno v:
Current Drug Target -CNS & Neurological Disorders. 2:269-277
The fine-tuning and homeostatic balance of the GABAergic inhibitory tone in the central nervous system (CNS) is a prerequisite for controlling the excitatory neurotransmission. This principal mechanism for controlling excitation is inhibition which h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daabecaefd06b6f3af9afe4d0b228db
https://doi.org/10.2174/1568007033482788
https://doi.org/10.2174/1568007033482788
Publikováno v:
Neurochemical research. 30(6-7)
The adaptation of cells to hyperosmotic conditions involves accumulation of organic osmolytes to achieve osmotic equilibrium and maintenance of cell volume. The Na+ and Cl(-)-coupled betaine/GABA transporter, designated BGT-1, is responsible for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4cc3c071573d88fecf42a689a44671
https://pubmed.ncbi.nlm.nih.gov/16187220
https://pubmed.ncbi.nlm.nih.gov/16187220
Autor:
Povl Krogsgaard-Larsen, Arne Schousboe, Gitte Petersen, William Patrick Watson, Erik Falch, Alan Sarup, Scott Slough, Rasmus P. Clausen, Suzanne L. Hansen, H. Steve White, Bente Frølund, Tina Bolvig, Orla M. Larsson, Jens Kristian Perregaard
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 312(2)
In a recent study, EF1502 [ N -[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-hydroxy-4-(methylamino)-4,5,6,7-tetrahydrobenzo [ d ]isoxazol-3-ol], which is an N -substituted analog of the GAT1-selective GABA uptake inhibitor exo -THPO (4-amino-4,5,6,7-tet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f6750c7cc5e12591fc684f49520f7a
https://pubmed.ncbi.nlm.nih.gov/15550575
https://pubmed.ncbi.nlm.nih.gov/15550575
Publikováno v:
Molecular Neuropharmacology ISBN: 9781617373848
γ-Aminobutyric acid (GABA) neurotransmission is characterized by the restricted expression of the GABA-synthesizing enzyme glutamate decarboxylase (GAD), the GABA receptors, and the GABA transporters in GABAergic synapses consisting of a presynaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf5d6c4d15a9ce707ad2a81cc28a5829
https://doi.org/10.1007/978-1-59259-672-0_10
https://doi.org/10.1007/978-1-59259-672-0_10
Autor:
Nathan Nelson, Bente Frolund, Tina Bolvig, Anders S. Kristensen, Povl Krogsgaard-Larsen, H. Steve White, Gitte Petersen, Alan Sarup, Darryl S. Pickering, Orla M. Larsson, Arne Schousboe
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 302(2)
The inhibitory effect of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole ( exo -THPO) and its N -methylated ( N -methyl- exo -THPO) and N -ethylated ( N -ethyl- exo -THPO) analogs, derived from γ-aminobutyric acid (GABA) and 4,5,6,7-tetrahydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062af28b205eb391f0a2de782c279b3e
https://pubmed.ncbi.nlm.nih.gov/12130726
https://pubmed.ncbi.nlm.nih.gov/12130726
Publikováno v:
Neurochemical Research; Jun2005, Vol. 30 Issue 6/7, p855-865, 11p
Autor:
Steve, White H, P, Watson William, L, Hansen Suzanne, Scott, Slough, Jens, Perregaard, Alan, Sarup, Tina, Bolvig, Gitte, Petersen, M, Larsson Orla, P, Clausen Rasmus, Bente, Frlund, Erik, Falch, Povl, Krogsgaard-Larsen, Arne, Schousboe
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; February 2005, Vol. 312 Issue: 2 p866-74, 9p
Autor:
Steve, White H, Alan, Sarup, Tina, Bolvig, S, Kristensen Anders, Gitte, Petersen, Nathan, Nelson, S, Pickering Darryl, M, Larsson Orla, Bente, Frlund, Povl, Krogsgaard-Larsen, Arne, Schousboe
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; August 2002, Vol. 302 Issue: 2 p636-44, 9p