Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β

Autor: Marcela Cespedes, Kelly R. Jacobs, Paul Maruff, Alan Rembach, Christopher J. Fowler, Brett Trounson, Kelly K. Pertile, Rebecca L. Rumble, Stephanie R. Rainey-Smithe, Christopher C. Rowe, Victor L. Villemagne, Pierrick Bourgeat, Chai K. Lim, Pratishtha Chatterjee, Ralph N. Martins, Arne Ittner, Colin L. Masters, James D. Doecke, Gilles J. Guillemin, David B. Lovejoy

Publikováno v: Neurobiology of Disease, Vol 171, Iss , Pp 105783- (2022)

Increasing evidence suggests that kynurenine pathway (KP) dyshomeostasis may promote disease progression in dementia. Studies in Alzheimer's disease (AD) patients confirm KP dyshomeostasis in plasma and cerebrospinal fluid (CSF) which correlates with

Externí odkaz: https://doaj.org/article/75df2cb1e7904b2c830ffb9d9588ebf8

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease

Autor: Ying Xia, Vincent Dore, Victor L. Villemagne, Brendan S. Silbert, Jurgen Fripp, James D. Doecke, Elise J Harrison, Adrian Kamer, Robert Grenfell, Madeline Peretti, Simon McBride, Christopher C. Rowe, Paul Maruff, Lidija Milicic, Kelly K. Pertile, Steven J. Collins, Tania Taddei, Christine Thai, Andrea G. Louey, Michael Weinborn, Richard Head, Pierrick Bourgeat, Colin L. Masters, Olivier Salvado, Sabine Bird, S. Lance Macaulay, Rebecca L. Rumble, Michael Vacher, Simon Gibson, Lucy Lim, Amir Fazlollahi, Samantha C. Burnham, Kathryn A. Ellis, Yen Ying Lim, Regan Tyrrell, Julia Bomke, Michael Woodward, Belinda M. Brown, Joanne Robertson, Brett Trounson, Simon M. Laws, Carolyn Chadunow, Magdalene Soh, Liang Jin, Morgan Radler, Greg Savage, Christopher Fowler, Ralph N. Martins, Samantha L. Gardener, Fiona Lamb, Mark Rodrigues, Lucy Mackintosh, David Ames, Stephanie R. Rainey-Smith, Lis Evered, Alan Rembach, Tenielle Porter, Qiao-Xin Li, Nicola T. Lautenschlager, Shiji Varghese, Ashley I. Bush, Hamid R. Sohrabi, Kevin Taddei

Publikováno v: Journal of Alzheimer's Disease Reports

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer’s disease dementi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e07af9577c53e82690da4f8a490ad4
http://europepmc.org/articles/PMC8293663

Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies

Autor: Victor L. Villemagne, Shaun Frost, Prita R. Asih, Kevin Taddei, James D. Doecke, Eugene Hone, Samantha C. Burnham, Kathryn A. Ellis, Giuseppe Verdile, Ralph N. Martins, Veer Bala Gupta, Simon M. Laws, Olivier Salvado, David Ames, Ian Martins, Pratishtha Chatterjee, Wei Ling Lim, Christopher C. Rowe, Sunil Gupta, Eka J. Wahjoepramono, Tejal M. Shah, Belinda M. Brown, Sam Gandy, Kathryn Goozee, Sid E. O'Bryant, Colin L. Masters, Paul E. Fraser, Binosha Fernando, Alan Rembach, Steve Pedrini, Prashant Bharadwaj, Samantha L. Gardener, Stephanie R. Rainey-Smith, Stephanie J. Fuller, Hamid R. Sohrabi, Ashley I. Bush, Anna M. Barron

Publikováno v: Journal of Alzheimer's Disease

Worldwide there are over 46 million people living with dementia, and this number is expected to double every 20 years reaching about 131 million by 2050. The cost to the community and government health systems, as well as the stress on families and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6494a1cbbe5ae8cab6cad281fba6a1
https://doi.org/10.3233/jad-171145

Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging

Autor: David Ames, Christopher C. Rowe, Colin L. Masters, S L Macaulay, Simon M. Laws, Veer Bala Gupta, Victor L. Villemagne, Alan Rembach, Eugene Hone, Stephanie R. Rainey-Smith, Ralph N. Martins, Ashley I. Bush, Madhav Thambisetty, James D. Doecke, Steve Pedrini

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 3, Iss 1, Pp 18-26 (2016)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Introduction For early detection of Alzheimer's disease (AD), the field needs biomarkers that can be used to detect disease status with high sensitivity and specificity. Apolipoprotein J (ApoJ, also known as clusterin) has long been associated with A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe4915ea1baadd455d6c8c3d02c7a2a
https://doi.org/10.1016/j.dadm.2015.12.001

Comparative analysis of the Cancer Council of Victoria and the online Commonwealth Scientific and Industrial Research Organisation FFQ

Autor: Paul Maruff, Christopher C. Rowe, S. Lance Macaulay, Jennifer B Keogh, Stephanie R. Rainey-Smith, Samantha L. Gardener, Kathryn A. Ellis, David Ames, Alan Rembach, Kevin Taddei, Colin L. Masters, Ralph N. Martins

Publikováno v: British Journal of Nutrition. 114:1683-1693

FFQ are commonly used to examine the association between diet and disease. They are the most practical method for usual dietary data collection as they are relatively inexpensive and easy to administer. In Australia, the Cancer Council of Victoria FF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d4d253ebbf835be0c92f57f6136047
https://doi.org/10.1017/s0007114515003335