Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alan, Norris"'
Autor:
Louise Y. Takeshita, Alan Norris, Ania Wilczynska, Amy Schofield, Robert Sutton, Jens Allmer, Lawrence Howell, Eunice Zhang, Matthias Hackl, Shiva S. Forootan, Paul Reeves, Mika Remes, Stephen Lee, Francesco Falciani, Joseph P Brown, Warren E. Glaab, James W. Dear, Jack Brown, Christopher E. Goldring, B. Kevin Park, Catherine C. Bell
Publikováno v:
Archives of Toxicology, 95(11), 3475-3495
Archives of Toxicology
ARCHIVES OF TOXICOLOGY
Archives of Toxicology 95 (2021) 11
Schofield, A L, Brown, J P, Brown, J, Wilczynska, A, Bell, C, Glaab, W E, Hackl, M, Howell, L, Lee, S, Dear, J W, Remes, M, Reeves, P, Zhang, E, Allmer, J, Norrish, A, Falciani, F, Takeshita, L Y, Forootan, S S, Sutton, R, Park, B K & Goldring, C 2021, ' Systems Analysis of miRNA Biomarkers to Inform Drug Safety ', Archives of toxicology . https://doi.org/10.1007/s00204-021-03150-9
Archives of Toxicology
ARCHIVES OF TOXICOLOGY
Archives of Toxicology 95 (2021) 11
Schofield, A L, Brown, J P, Brown, J, Wilczynska, A, Bell, C, Glaab, W E, Hackl, M, Howell, L, Lee, S, Dear, J W, Remes, M, Reeves, P, Zhang, E, Allmer, J, Norrish, A, Falciani, F, Takeshita, L Y, Forootan, S S, Sutton, R, Park, B K & Goldring, C 2021, ' Systems Analysis of miRNA Biomarkers to Inform Drug Safety ', Archives of toxicology . https://doi.org/10.1007/s00204-021-03150-9
microRNAs (miRNAs or miRs) are short non-coding RNA molecules which have been shown to be dysregulated and released into the extracellular milieu as a result of many drug and non-drug-induced pathologies in different organ systems. Consequently, circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcaf46aa3c68baa2229deb7d5be082f
https://research.wur.nl/en/publications/systems-analysis-of-mirna-biomarkers-to-inform-drug-safety
https://research.wur.nl/en/publications/systems-analysis-of-mirna-biomarkers-to-inform-drug-safety
Autor:
Munir Pirmohamed, David Cavalla, Andrew D. Wells, Andrew J. Doig, Philippe Sanseau, Tim Guilliams, Francesco Iorio, Christine J. McNamee, Sudeep Pushpakom, K. Jane Escott, Joanna Latimer, Shirley Hopper, Patrick A. Eyers, Alan Norris
Publikováno v:
NATURE REVIEWS DRUG DISCOVERY
Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821d3e357a2d91fb1cfb7090bc94e339
https://pubmed.ncbi.nlm.nih.gov/30310233
https://pubmed.ncbi.nlm.nih.gov/30310233
Publikováno v:
Clinical medicine (London, England). 18(1)
We present the case of a 67-year-old man who suffered an acute anaphylactic reaction during red cell transfusion due to the presence of anti-IgA antibodies. The incidence and clinical relevance of anti-IgA antibodies in IgA deficiency is reviewed, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779b40398b66a9db4ff3db65f56d77a0
https://pubmed.ncbi.nlm.nih.gov/29436447
https://pubmed.ncbi.nlm.nih.gov/29436447
Autor:
Munir Pirmohamed, P J M Clements, Michael J. Cross, James E. Sidaway, Alan Norris, Laura Cove-Smith, Howard R. Mellor, M Holbrook, P Hoffmann, Alexander R. Lyon, Brian R. Berridge, Thomas Force, Jonathan Tugwood, B.K. Park
Publikováno v:
British Journal of Pharmacology. 172:957-974
The incidence of drug-induced structural cardiotoxicity, which may lead to heart failure, has been recognized in association with the use of anthracycline anti-cancer drugs for many years, but has also been shown to occur following treatment with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a42b2c1f504ed84acc1d38c2ab3b60
https://doi.org/10.1111/bph.12979
https://doi.org/10.1111/bph.12979
Publikováno v:
Acta haematologica. 139(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b140921d4f3fb14a9361fa7648493a9
https://pubmed.ncbi.nlm.nih.gov/29945125
https://pubmed.ncbi.nlm.nih.gov/29945125
Autor:
Seyoum Ayehunie, Howard R. Mellor, Robert G. Vries, Alan Norris, Chris Probert, Alexander Penrose, Munir Pirmohamed, Shashi K. Ramaiah, B. Kevin Park, Alison Shaw, Andrea Davies, James E. Sidaway, Claire Sadler, Michael Schmitt, Syed A. Hussain, D. Mark Pritchard, Daniel F. Carr, Matthew Wagoner, Stephanie French, Carrie A. Duckworth, Neil Hall
Publikováno v:
PHARMACOLOGY & THERAPEUTICS
Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013fea942d2efe4f3854bdfe76704cec
https://pubmed.ncbi.nlm.nih.gov/28132905
https://pubmed.ncbi.nlm.nih.gov/28132905
Autor:
David C. Hay, Satu Juhila, Christopher E. Goldring, Frank Bonner, Alan Norris, Neil A. Hanley, Belen Tornesi, Robert J. Fontana, B. Kevin Park, Chris S. Pridgeon, Chris Denning, Richard J. Weaver, Bob van de Water, Beatriz Silva-Lima, Neil R. Kitteringham, Rowena Sison Young, Magnus Ingelman-Sundberg, Jonathan Crozier, Daniel J. Antoine, Danilo Tagle, James A. Ross, Fang Zhang
Publikováno v:
HEPATOLOGY
Goldring, C E, Antoine, D J, Bonner, F, Crozier, J, Denning, C, Fontana, R, Hanley, N A, Hay, D C, Ingelman-Sundberg, M, Juhila, S, Kitteringham, N R, de Lima, B, Norrish, A, Pridgeon, C S, Ross, J, Sison-Young, R L C, Tagle, D, Tournesi, B, van der Water, B, Weaver, R, Zhang, F & Park, K 2017, ' Stem cell-derived models to improve mechanistic understanding and prediction of human drug induced liver injury ', Hepatology, pp. 710-721 . https://doi.org/10.1002/hep.28886
Goldring, C, Antoine, D J, Bonner, F, Crozier, J, Denning, C, Fontana, R J, Hanley, N A, Hay, D C, Ingelman-Sundberg, M, Juhila, S, Kitteringham, N, Silva-Lima, B, Norris, A, Pridgeon, C, Ross, J A, Young, R S, Tagle, D, Tornesi, B, van de Water, B, Weaver, R J, Zhang, F & Park, B K 2016, ' Stem cell–derived models to improve mechanistic understanding and prediction of human drug-induced liver injury ', Hepatology, vol. 65, no. 2, pp. 710-721 . https://doi.org/10.1002/hep.28886
Hepatology
Hepatology, 65(2), 710-721
Goldring, C E, Antoine, D J, Bonner, F, Crozier, J, Denning, C, Fontana, R, Hanley, N A, Hay, D C, Ingelman-Sundberg, M, Juhila, S, Kitteringham, N R, de Lima, B, Norrish, A, Pridgeon, C S, Ross, J, Sison-Young, R L C, Tagle, D, Tournesi, B, van der Water, B, Weaver, R, Zhang, F & Park, K 2017, ' Stem cell-derived models to improve mechanistic understanding and prediction of human drug induced liver injury ', Hepatology, pp. 710-721 . https://doi.org/10.1002/hep.28886
Goldring, C, Antoine, D J, Bonner, F, Crozier, J, Denning, C, Fontana, R J, Hanley, N A, Hay, D C, Ingelman-Sundberg, M, Juhila, S, Kitteringham, N, Silva-Lima, B, Norris, A, Pridgeon, C, Ross, J A, Young, R S, Tagle, D, Tornesi, B, van de Water, B, Weaver, R J, Zhang, F & Park, B K 2016, ' Stem cell–derived models to improve mechanistic understanding and prediction of human drug-induced liver injury ', Hepatology, vol. 65, no. 2, pp. 710-721 . https://doi.org/10.1002/hep.28886
Hepatology
Hepatology, 65(2), 710-721
Current preclinical drug testing does not predict some forms of adverse drug reactions in humans. Efforts at improving predictability of drug-induced tissue injury in humans include using stem cell technology to generate human cells for screening for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbacc462a980918f9159ad06183577a
https://hdl.handle.net/1887/69184
https://hdl.handle.net/1887/69184
Publikováno v:
Journal of the American Veterinary Medical Association. 244(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::896b44545cc446a9b7cb96aaed396d10
https://pubmed.ncbi.nlm.nih.gov/24568103
https://pubmed.ncbi.nlm.nih.gov/24568103
Publikováno v:
Advances in Therapy. 17:7-13
The effects of intravenous administration of nedocromil sodium were investigated in active and passive models of conjunctival immediate hypersensitivity in rats. In the active sensitization model, animals were immunized with ovalbumin 21 days prior t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbce19bc23b01001d7002028bca5990
https://doi.org/10.1007/bf02868026
https://doi.org/10.1007/bf02868026
Autor:
Jack P. Leek, Alan Norris, Alexander F. Markham, John F. J. Morrison, Roslan B. Harun, Kim Smith
Publikováno v:
Genomics. 42:349-352
SHC is an adapter protein in the Ras-MAPkinase pathway that is involved in the regulation of cell growth and differentiation. The p46 and p52 isoforms are thought to be produced by the use of two alternative translation initiation sites in a 3.4-kb t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16bd14c5a46c93b0953a91c4146bf90
https://doi.org/10.1006/geno.1997.4728
https://doi.org/10.1006/geno.1997.4728