Výsledky vyhledávání - "Alan, Meeker"

Akademický článek

Proteomic characterization of primary and metastatic prostate cancer reveals reduced proteinase activity in aggressive tumors

Autor: Qing Kay Li, Jing Chen, Yingwei Hu, Naseruddin Höti, Tung-Shing Mamie Lih, Stefani N. Thomas, Li Chen, Sujayita Roy, Alan Meeker, Punit Shah, Lijun Chen, G. Steven Bova, Bai Zhang, Hui Zhang

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Prostate cancer (PCa) is a heterogeneous group of tumors with variable clinical courses. In order to improve patient outcomes, it is critical to clinically separate aggressive PCa (AG) from non-aggressive PCa (NAG). Although recent genomic s

Externí odkaz: https://doaj.org/article/eec67f5b900a4b039dc046a5f2d3d03b

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Data from Monoallelic IDH1 R132H Mutation Mediates Glioma Cell Response to Anticancer Therapies via Induction of Senescence

Autor: Shuli Xia, Hernando Lopez-Bertoni, Alan Meeker, Yunqing Li, Mingyao Ying, John Laterra, Charles Eberhart, Yi Fu, Bachchu Lal, Shuang Wei, Ding Ma, Daqian Zhan

Heterozygous isocitrate dehydrogenase (IDH) R132H mutation (IDH1R132H/WT) is an early event during gliomagenesis. Clinically, patients with glioma carrying mutant IDH1 respond better to antitumor therapies. However, the mechanism by which IDH1 mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::682c284acfcb91ec55ff1ce01a632820
https://doi.org/10.1158/1541-7786.c.6545270.v1

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Supplementary Material, Table 1, Supplementary Figures 1-8 from Monoallelic IDH1 R132H Mutation Mediates Glioma Cell Response to Anticancer Therapies via Induction of Senescence

Autor: Shuli Xia, Hernando Lopez-Bertoni, Alan Meeker, Yunqing Li, Mingyao Ying, John Laterra, Charles Eberhart, Yi Fu, Bachchu Lal, Shuang Wei, Ding Ma, Daqian Zhan

Supplementary Table 1. Primers used for qRT-PCR Supplementary Fig. 1. Heterozygous IDH1R132H/WT enhanced therapy-induced senescence in glioma cells. Supplementary Fig. 2. a. Schematic graph of genome editing strategy with two guide RNAs to knock out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c7a77d9f6ac5d15ed2eff1238245ee
https://doi.org/10.1158/1541-7786.22526966

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Data from BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model

Autor: Charles G. Eberhart, Kenneth J. Cohen, Eli Bar, Deepali Jain, Ulf Kahlert, Jarek Maciaczyk, Guido Nikkhah, Xing-gang Mao, Alan Meeker, Julia M. Kim, Kah Suan Lim, Eric H. Raabe

Purpose: BRAF is frequently activated by gene fusion or point mutation in pilocytic astrocytoma, the most common pediatric brain tumor. We investigated the functional effect of constitutive BRAF activation in normal human neural stem and progenitor c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458cb5c7bd899938803b47cb387bae28
https://doi.org/10.1158/1078-0432.c.6519392.v1

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Supplementary Figures S1-S3 from BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model

Autor: Charles G. Eberhart, Kenneth J. Cohen, Eli Bar, Deepali Jain, Ulf Kahlert, Jarek Maciaczyk, Guido Nikkhah, Xing-gang Mao, Alan Meeker, Julia M. Kim, Kah Suan Lim, Eric H. Raabe

Supplementary Figures S1-S3 from BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95c9bcce26e1052f837a840392715d4
https://doi.org/10.1158/1078-0432.22442723

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LY6S, a New IFN-Inducible Human Member of the Ly6a Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

Publikováno v: ImmunoHorizons. 6:253-272

Syntenic genomic loci on human chromosome 8 and mouse chromosome 15 (mChr15) code for LY6/Ly6 (lymphocyte Ag 6) family proteins. The 23 murine Ly6 family genes include eight genes that are flanked by the murine Ly6e and Ly6l genes and form an Ly6 sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87646f4a2a00f85fec104172b08a2900
https://doi.org/10.4049/immunohorizons.2200018

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Akademický článek

MUC1-ARF-A Novel MUC1 Protein That Resides in the Nucleus and Is Expressed by Alternate Reading Frame Translation of MUC1 mRNA.

Autor: Michael Chalick, Oded Jacobi, Edward Pichinuk, Christian Garbar, Armand Bensussan, Alan Meeker, Ravit Ziv, Tania Zehavi, Nechama I Smorodinsky, John Hilkens, Franz-Georg Hanisch, Daniel B Rubinstein, Daniel H Wreschner

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165031 (2016)

Translation of mRNA in alternate reading frames (ARF) is a naturally occurring process heretofore underappreciated as a generator of protein diversity. The MUC1 gene encodes MUC1-TM, a signal-transducing trans-membrane protein highly expressed in hum

Externí odkaz: https://doaj.org/article/e148be4c47a04d5dbe84a96ede250065

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LY6S, a New Interferon-Inducible Human Member of the Ly6a-Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

Syntenic genomic loci on human chromosome 8 (hChr8) and mouse chromosome 15 (mChr15) code for LY6/Ly6 (lymphocyte antigen 6) family proteins. The 23 murine Ly6 family genes include eight genes that are flanked by the murine Ly6e and Ly6l genes and fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::477f97a0c4064d87ae2f115ee9e8564e
https://doi.org/10.1101/2021.12.16.472998

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In vivo anti-MUC1

Autor: Edward, Pichinuk, Michael, Chalik, Itai, Benhar, Ravit, Ginat-Koton, Ravit, Ziv, Nechama I, Smorodinsky, Gabi, Haran, Christian, Garbar, Armand, Bensussan, Alan, Meeker, Thierry, Guillaume, Daniel B, Rubinstein, Daniel H, Wreschner

Publikováno v: Cancer immunology, immunotherapy : CII. 69(7)

Cleavage of the MUC1 glycoprotein yields two subunits, an extracellular alpha-subunit bound to a smaller transmembrane beta-subunit. Monoclonal antibodies (mAbs) directed against the MUC1 alpha-beta junction comprising the SEA domain, a stable cell-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::122e605b8c4e92a37fe1df46ab8a51a0
https://pubmed.ncbi.nlm.nih.gov/32219500

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