Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alan, Main"'
Autor:
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://doaj.org/article/1dff52e3692941429b8b20d7536589fd
Autor:
James E. Grace, Brian Zambrowicz, Pradeep Vattikundala, Kenneth G. Carson, Jonathan Lippy, Clotilde Bourin, Alan Main, Alan Wilson, Sreenivasulu Naidu, Sandhya Mandlekar, Carolyn Diane Dzierba, Saravanan Elavazhagan, Walter Kostich, Gauri Shankar, Jeffrey M. Brown, Charles M. Conway, Charles F. Albright, Justin Vijay Louis, Yu-Wen Li, Vivek Sharma, Yanling Huang, Laszlo Kiss, Amr Nouraldeen, Susheel J. Nara, Martin A. Lewis, Ryan Westphal, Vinay K. Holenarsipur, Anand Balakrishnan, Amy Easton, Robert Zaczek, Jonathan C. Swaffield, Ted Molski, Rick L. Pieschl, Kevin Baker, Katerina Savelieva, Yingzhi Bi, Kenneth S. Santone, Linda J. Bristow, John E. Macor, Jianlin Feng, Guilan Ye, Joanne J. Bronson, Manish Lal Das, Reeba K. Vikramadithyan, Kevin O’Malley, Jason W. Allen, Brian D. Hamman, Michael Gulianello, Yifeng Lu, Thomas H. Lanthorn, Kimberley A. Lentz, Anoop Kumar, Manoj Dokania, Kumaran Dandapani, Rex Denton
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b1480bd30607a9fe64d0e01fbd6b27
http://europepmc.org/articles/PMC4998676
http://europepmc.org/articles/PMC4998676
Autor:
Alan Wilson, Iris B. Owusu, Boteju Lakmal W, Saadat Aleem, Philip Manton Brown, Jack Yan, Theodore C. Jessop, David J. Augeri, Suman Layek, Zhong Lai, S. David Kimball, Jill Hazelwood, William Heydorn, Kenneth G. Carson, Tamas Oravecz, Liam Moran, Suma Gopinathan, Haiming Zhang, Michael S. Donoviel, Amr Nouraldeen, William K. Sonnenburg, Jeffrey T. Bagdanoff, Jeffrey A. Kramer, Alan Main, Barbara Brooks, Li Dong, James E. Tarver, Padmaja Yalamanchili, Kenny Frazier, Marianne Carlsen, Mark S. Bednarz
Publikováno v:
Journal of Medicinal Chemistry. 53:8650-8662
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in vivo evaluation of synthetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87e00a9781c267b0a4f8d1324759661
https://doi.org/10.1021/jm101183p
https://doi.org/10.1021/jm101183p
Autor:
Haihong Jin, Zhi-Cai Shi, Alan Main, Lakshman Samala, Chengmin Zhang, Qingyun Liu, Giovanni Cianchetta, Xiang Qing Yu, Ying Wang, David R. Powell, Weimei Sun, Zhi Ming Ding, Qi M. Yang, Kunjian Gu, Yi Zang, Alan Wilson, Ashok Tunoori, S. David Kimball, Terry R. Stouch, Arokiasamy Devasagayaraj, Brett A. Marinelli, Sheldon Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5229-5232
Tryptophan hydroxylase (TPH) is a key enzyme in the synthesis of serotonin. As a neurotransmitter, serotonin plays important physiological roles both peripherally and centrally. Here we describe the discovery of substituted triazines as a novel class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f331ad2c606d9f90d192ff5b4b042d3
https://doi.org/10.1016/j.bmcl.2009.07.005
https://doi.org/10.1016/j.bmcl.2009.07.005
Autor:
Qingyun Liu, Weimei Sun, Amr Nouraldeen, Lawrence F. Courtney, Alan Wilson, Suman Layek, Marianne Carlsen, Sean Yu, Mark S. Bednarz, Zhong Lai, Ann Marie Digeorge-Foushee, Tamas Oravecz, Jerry A. Taylor, Traci Smith, Haiming Zhang, Liam Moran, Jonathan C. Swaffield, Debra Bruce, Jill Hazelwood, Simon D.P. Baugh, David J. Augeri, Emily O’Neill, Joseph Barbosa, Kristen M. Terranova, Suma Gopinathan, Gardyan Michael Walter, Huy Van Nguyen, S. David Kimball, Jeffrey T. Bagdanoff, Jack Yan, Theodore C. Jessop, Michael S. Donoviel, Qinghong Fu, Jeffrey A. Kramer, Alan Main, James E. Tarver, Kenneth G. Carson
Publikováno v:
Journal of Medicinal Chemistry. 52:3941-3953
During nearly a decade of research dedicated to the study of sphingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of autoimmune disorders. S1PL catalyzes the irreversible decomposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adb6db472626b33c48fc85b6ff019d0
https://doi.org/10.1021/jm900278w
https://doi.org/10.1021/jm900278w
Autor:
Jason Allen, Kenneth G. Carson, Brian D. Hamman, Amin Al-Shami, Peter Vogel, Kanchan G. Jhaver, Carrie Wilkins, Wei-Chun Chang, Brian Zambrowicz, Kenneth A. Platt, Alan Main, Ann Marie Digeorge-Foushee, Tamas Oravecz, David J. Augeri, R. Read, Konstantin V. Salojin, Jonathan C. Swaffield, Suma Gopinathan, Theodore C. Jessop, Jeffrey T. Bagdanoff, Nita Patel, Alan Wilson, Jeannette Crisostomo, Amr Nouraldeen, Julia Zhou
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
PLoS ONE
PLoS ONE
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab72ed43ba6f3801b3c10d3473e5d2d
http://europepmc.org/articles/PMC4031148?pdf=render
http://europepmc.org/articles/PMC4031148?pdf=render
Publikováno v:
Headache: The Journal of Head and Face Pain. 40:194-199
Objective.–To ascertain the wavelength of light that patients with migraine and tension-type headache find uncomfortable between attacks. Background.–Photophobia is an abnormal perceptual sensitivity to light experienced by most patients with hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f610f678284c9065f9b990d9e1d28a2f
https://doi.org/10.1046/j.1526-4610.2000.00028.x
https://doi.org/10.1046/j.1526-4610.2000.00028.x
Publikováno v:
Headache: The Journal of Head and Face Pain. 37:492-495
This study investigated whether migraineurs are more sensitive to light and sound while headache-free than are healthy people. Fifty-two migraineurs (mean age 39 years) were selected using the International Headache Society diagnostic criteria for mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23b42ef70b9aec174b4c66f5b3365ea
https://doi.org/10.1046/j.1526-4610.1997.3708492.x
https://doi.org/10.1046/j.1526-4610.1997.3708492.x
Autor:
Jeffrey T, Bagdanoff, Michael S, Donoviel, Amr, Nouraldeen, Marianne, Carlsen, Theodore C, Jessop, James, Tarver, Saadat, Aleem, Li, Dong, Haiming, Zhang, Lakmal, Boteju, Jill, Hazelwood, Jack, Yan, Mark, Bednarz, Suman, Layek, Iris B, Owusu, Suma, Gopinathan, Liam, Moran, Zhong, Lai, Jeff, Kramer, S David, Kimball, Padmaja, Yalamanchili, William E, Heydorn, Kenny S, Frazier, Barbara, Brooks, Philip, Brown, Alan, Wilson, William K, Sonnenburg, Alan, Main, Kenneth G, Carson, Tamas, Oravecz, David J, Augeri
Publikováno v:
Journal of medicinal chemistry. 53(24)
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in vivo evaluation of synthetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::204bf8f2e5cfe6d6fe7e35186b834e44
https://pubmed.ncbi.nlm.nih.gov/21090716
https://pubmed.ncbi.nlm.nih.gov/21090716
Autor:
Theodore C. Jessop, Alan Wilson, Brian D. Hamman, Kenneth G. Carson, Peter Vogel, Alan Main, Bagdanoff Jeffrey, Amin Al-Shami, David J. Augeri, Jonathan C. Swaffield, Kanchan G. Jhaver, Brian Zambrowicz, Tamas Oravecz, Wei-Chun Chang
Publikováno v:
Annals of the Rheumatic Diseases. 72:A118.3-A118
Background The mammalian sterile 20-like kinase 1 (MST1) is a MAP4 kinase which acts upstream of a wide range of signal transduction pathways. It can modify signaling events mediated by Jnk, p38, histone 2B, hSav, FOXO3, and LFA-1; therefore it is in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5499b5d447eb00756dd3a483812022bf
https://doi.org/10.1136/annrheumdis-2013-eular.400
https://doi.org/10.1136/annrheumdis-2013-eular.400