Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alan, Jeuken"'
Autor:
Morgan Jouanneau, Jean-Pierre Férézou, Janick Ardisson, Karunakar Reddy Bonepally, Aurélien Tap, Régis Guillot, Joëlle Prunet, Alan Jeuken
Publikováno v:
Organic Letters. 20:2176-2180
A new and flexible approach toward the synthesis of 6,12-guaianolide anticancer drugs such as trilobolides or thapsigargin has been developed that could be applied to the preparation of analogues with a modified ring system. The synthesis starts from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d4f3594a1ef3bfae6c862b9e757f4a
https://doi.org/10.1021/acs.orglett.8b00456
https://doi.org/10.1021/acs.orglett.8b00456
Autor:
Alan Jeuken, Geoffroy Sorin, Mohamed Selkti, Youssouf Sanogo, Janick Ardisson, Raja Ben Othman, Sabrina Dhambri, Joëlle Prunet, Jean-Pierre Férézou, Marie-Isabelle Lannou
Publikováno v:
Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (9), pp.5821-5830. ⟨10.1021/acs.joc.8b03249⟩
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (9), pp.5821-5830. ⟨10.1021/acs.joc.8b03249⟩
A novel approach toward the [5—7]fused bicyclic core of thapsigargin, a subnanomolar inhibitor of the endo/sarcoplasmic calcium ATPase (SERCA), is presented. The synthetic route includes an original Ti(II)-mediated hydroxy-directed reductive coupli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df22f3cd47dc7dcaa5efcf6848763b3
https://hal.archives-ouvertes.fr/hal-02370403/document
https://hal.archives-ouvertes.fr/hal-02370403/document
The origins of the stereodivergence in the thioester oxy-Michael cyclization for the formation of 4-hydroxy-2,6-cis- or 2,6-trans-substituted tetrahydropyran rings under different conditions was investigated both computationally and experimentally. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c90cc5b9cfe7de606a98cbcbbae6528
https://eprints.whiterose.ac.uk/104199/1/Clarke_THP_Revised_Submitted.pdf
https://eprints.whiterose.ac.uk/104199/1/Clarke_THP_Revised_Submitted.pdf
Publikováno v:
Chemical Science
Computational and synthetic studies have elucidated the origins of stereodivergence in an oxy-Michael synthesis of 2,6-disubstituted tetrahydropyrans.
The origins of the stereodivergence in the thioester oxy-Michael cyclization for the formation
The origins of the stereodivergence in the thioester oxy-Michael cyclization for the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aef011b39dc8280dd7f7e8b5245b1ab3
https://pubmed.ncbi.nlm.nih.gov/28451195
https://pubmed.ncbi.nlm.nih.gov/28451195