Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alan, Hegron"'
Autor:
Francesco De Logu, Romina Nassini, Alan Hegron, Lorenzo Landini, Dane D. Jensen, Rocco Latorre, Julia Ding, Matilde Marini, Daniel Souza Monteiro de Araujo, Paulina Ramírez-Garcia, Michael Whittaker, Jeffri Retamal, Mustafa Titiz, Alessandro Innocenti, Thomas P. Davis, Nicholas Veldhuis, Brian L. Schmidt, Nigel W. Bunnett, Pierangelo Geppetti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The mechanism of CGRP-evoked peripheral pain is unclear. Here, the authors show that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.
Externí odkaz:
https://doaj.org/article/279bcfd8279341c7ae1422cec3fc2183
Autor:
Alan Hegron, Chloe J. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Dane D. Jensen, Alex R. B. Thomsen, Brian L. Schmidt, Wendy L. Imlach, Peter Gmeiner, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonis
Autor:
wenwen gao, lei liu, Eunna Huh, Alan Hegron, Zhiran Fan, Guofei Hou, Guillaume Charpentier, Mehdi Derhourhi, Michel Marre, Beverley Balkau, Philippe Froguel, Olivier Lichtarge, Julie Dam, Amélie Bonnefond, Jianfeng Liu, Ralf Jockers
The glucagon-like peptide 1 receptor (GLP1R) is a major drug target with several agonists being prescribed in patients with type 2 diabetes (T2D) and obesity. The impact of genetic variability of the GLP1R gene on receptor function and its associatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e89452032dd1336edbf25a1ef07b70e6
https://doi.org/10.21203/rs.3.rs-2114208/v1
https://doi.org/10.21203/rs.3.rs-2114208/v1
Autor:
Rocco Latorre, Alan Hegron, Chloe J. Peach, Shavonne Teng, Raquel Tonello, Jeffri S. Retamal, Rafael Klein-Cloud, Diana Bok, Dane D. Jensen, Lena Gottesman-Katz, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Alex R. B. Thomsen, Brian L. Schmidt, Charalabos H. Pothoulakis, Carl Rankin, Ying Xie, Hon Wai Koon, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 119
G protein–coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and sign
Autor:
Rocco, Latorre, Alan, Hegron, Chloe J, Peach, Shavonne, Teng, Raquel, Tonello, Jeffri S, Retamal, Rafael, Klein-Cloud, Diana, Bok, Dane D, Jensen, Lena, Gottesman-Katz, Jeanette, Rientjes, Nicholas A, Veldhuis, Daniel P, Poole, Brian L, Schmidt, Charalabos H, Pothoulakis, Carl, Rankin, Ying, Xie, Hon Wai, Koon, Nigel W, Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(6)
G protein-coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and signal
Autor:
Rocco Latorre, Paulina D. Ramírez-Garcia, Alan Hegron, James L. Grace, Jeffri S. Retamal, Priyank Shenoy, Mai Tran, Luigi Aurelio, Bernard Flynn, Daniel P. Poole, Rafael Klein-Cloud, Dane D. Jensen, Thomas P. Davis, Brian L. Schmidt, John F. Quinn, Michael R. Whittaker, Nicholas A. Veldhuis, Nigel W. Bunnett
Publikováno v:
Biomaterials
Soft polymer nanoparticles designed to disassemble and release an antagonist of the neurokinin 1 receptor (NK(1)R) in endosomes provide efficacious yet transient relief from chronic pain. These micellar nanoparticles are unstable and rapidly release
Autor:
Thomas P. Davis, Paulina D. Ramírez-García, Rocco Latorre, Alan Hegron, Matilde Marini, Daniel Souza Monteiro de Araujo, Julia Ding, Brian P. Schmidt, Romina Nassini, Dane D. Jensen, Mustafa Titiz, Michael R. Whittaker, Pierangelo Geppetti, Nigel W. Bunnett, Alessandro Innocenti, Jeffri S. Retamal, Francesco De Logu, Lorenzo Landini, Nicholas A. Veldhuis
Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe1d8c0f465f9e6d5ec91e7ca7f0355
https://doi.org/10.21203/rs.3.rs-758153/v1
https://doi.org/10.21203/rs.3.rs-758153/v1
Autor:
Shavonne Teng, Stephen Vanner, Alan Hegron, Jesse J. DiCello, Yang Yu, Josue Jaramillo-Polanco, Michelle L. Halls, Daniel P. Poole, Dane D. Jensen, Nicholas A. Veldhuis, Kam W. Leong, Nestor N. Jiménez-Vargas, Meritxell Canals, Brian L. Schmidt, Cintya Lopez-Lopez, Jing Gong, Alan E. Lomax, Simona E. Carbone, Matthew J. Wisdom, David E. Reed, Pradeep Rajasekhar, Nigel W. Bunnett, Rocco Latorre
Publikováno v:
Proc Natl Acad Sci U S A
Whether G protein-coupled receptors signal from endosomes to control important pathophysiological processes and are therapeutic targets is uncertain. We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of n
Autor:
Ralf Jockers, Alan Hegron
Publikováno v:
médecine/sciences
médecine/sciences, EDP Sciences, 2019, 35 (5), pp.412-416. ⟨10.1051/medsci/2019088⟩
médecine/sciences, EDP Sciences, 2019, 35 (5), pp.412-416. ⟨10.1051/medsci/2019088⟩
International audience; No abstract available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc24ec75b91aa6c61435fbebfbc3d85
https://hal.archives-ouvertes.fr/hal-02970164/document
https://hal.archives-ouvertes.fr/hal-02970164/document
Autor:
Angeliki, Karamitri, Bianca, Plouffe, Amélie, Bonnefond, Min, Chen, Jonathan, Gallion, Jean-Luc, Guillaume, Alan, Hegron, Mathilde, Boissel, Mickaël, Canouil, Claudia, Langenberg, Nicholas J, Wareham, Christian, Le Gouill, Viktoria, Lukasheva, Olivier, Lichtarge, Philippe, Froguel, Michel, Bouvier, Ralf, Jockers
Publikováno v:
Science signaling. 11(545)
Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-function variants in