Zobrazeno 1 - 10
of 491
pro vyhledávání: '"Alan, Gill"'
Autor:
Fernando G Vieira, Valerie R Tassinari, Joshua D Kidd, Andrew Moreno, Kenneth Thompson, Steven Perrin, Alan Gill, Theo Hatzipetros
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0292190 (2024)
Amyotrophic lateral sclerosis (ALS) has been linked to overactivity of the protein kinase RNA-like ER kinase (PERK) branch of the unfolded protein response (UPR) pathway, both in ALS patients and mouse models. However, attempts to pharmacologically m
Externí odkaz:
https://doaj.org/article/3f43e16213ce47a18658414260f2a41c
Autor:
Fernando G. Vieira, Theo Hatzipetros, Kenneth Thompson, Andy J. Moreno, Joshua D. Kidd, Valerie R. Tassinari, Beth Levine, Steven Perrin, Alan Gill
Publikováno v:
IBRO Reports, Vol 2, Iss C, Pp 47-53 (2017)
A copper chelator known as diacetylbis(N(4)-methylthiosemicarbazonato) copper II (CuATSM), has been reported to be efficacious in multiple transgenic SOD1 models of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting mot
Externí odkaz:
https://doaj.org/article/246f87e177af4a04ac08f48d41cbc051
Autor:
Fernando G Vieira, Qinggong Ping, Andy J Moreno, Joshua D Kidd, Kenneth Thompson, Bingbing Jiang, John M Lincecum, Monica Z Wang, Gerard S De Zutter, Valerie R Tassinari, Beth Levine, Theo Hatzipetros, Alan Gill, Steven Perrin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135570 (2015)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear. However, there is evidence for involvement of endoplasmic r
Externí odkaz:
https://doaj.org/article/f052d1fb3a364d89b9b51dacb83c5f26
Autor:
Emily J. Johnson, Alan Gill
Publikováno v:
Evidence-Based Practice. 24:14-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa6db1a47b74679d2b8fd1e6a21695f
https://doi.org/10.1097/ebp.0000000000000849
https://doi.org/10.1097/ebp.0000000000000849
Autor:
Lucas Labine, Alan Gill
Publikováno v:
Evidence-Based Practice. 25:33-34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3be25e8a17d0343c956f34c2abc7e205
https://doi.org/10.1097/ebp.0000000000001511
https://doi.org/10.1097/ebp.0000000000001511
Autor:
Fernando G Vieira, Eva LaDow, Andy Moreno, Joshua D Kidd, Beth Levine, Kenneth Thompson, Alan Gill, Steven Finkbeiner, Steven Perrin
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e91608 (2014)
Treatment options for people living with amyotrophic lateral sclerosis (ALS) are limited and ineffective. Recently, dexpramipexole (RPPX) was advanced into human ALS clinical trials. In the current studies, we investigated RPPX in two parallel screen
Externí odkaz:
https://doaj.org/article/b2f5a8bfa5d94825bb4e8c5d5954e8a7
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6489 (2009)
BACKGROUND: In any animal model of human disease a positive control therapy that demonstrates efficacy in both the animal model and the human disease can validate the application of that animal model to the discovery of new therapeutics. Such a thera
Externí odkaz:
https://doaj.org/article/7c8d71824d984c47ae07a7b3b779e1c3
Autor:
David Squire, Alan & Gill Bridgewater
Packed with practical advice from leading cultivation specialists, this concise, easy-to-use book covers virtually every aspect of garden design and maintenance—from choosing a plot to selecting plants, maximizing space and building raised beds. Pl
Autor:
Alan Gill, Fernando G. Vieira, Michael H. Rivner, Valerie R. Tassinari, Namita Goyal, Nazem Atassi, Daniela L. Grasso, Ericka Simpson, Sabrina Paganoni, James D. Berry, Nicte I. Mejia, Farrah J. Mateen, Eric A. Macklin, Stanley H. Appel, Steven Perrin
Publikováno v:
Muscle & Nerve. 56:1077-1084
INTRODUCTION: Immune activation is implicated in ALS progression. Oral fingolimod reduces circulating lymphocytes. The objective of this phase IIa randomized controlled trial was to test the short-term safety, tolerability, and target engagement of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f743d89b9b3a8293408b8fdead89b3
https://doi.org/10.1002/mus.25733
https://doi.org/10.1002/mus.25733
Autor:
Alan Gill, Fernando G. Vieira, Beth Levine, Kenneth Thompson, Theo Hatzipetros, Valerie R. Tassinari, Joshua D. Kidd, Andy J. Moreno, Steven Perrin
Publikováno v:
IBRO Reports
IBRO Reports, Vol 2, Iss C, Pp 47-53 (2017)
IBRO Reports, Vol 2, Iss C, Pp 47-53 (2017)
A copper chelator known as diacetylbis(N(4)-methylthiosemicarbazonato) copper II (CuATSM), has been reported to be efficacious in multiple transgenic SOD1 models of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a7892d4aac58a2c10191fe78acc006