Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Alan, Cunningham"'
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Inhibition of specific metabolic pathways often drives metabolic adaptation. Here, the authors show that FLT3-ITD + acute myeloid leukemia cells are OXPHOS-driven, and inhibition of complex II activity results in increased lactate influx to drive res
Externí odkaz:
https://doaj.org/article/c6190c32ad6545bcbde3640dce0f4ff7
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Roldán Cortés, Alan Cunningham, Maurien G. Pruis, Bauke de Boer, Fiona A. J. van den Heuvel, Marjan Geugien, Albertus T. J. Wierenga, Annet Z. Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Acute myeloid leukemia (AML) is genetically a very heterogeneous disease. Here, Erdem et al. uncover heterogeneity in the metabolic landscape of AML and identify Pyruvate dehydrogenase kinase 1 (PDK1) as a targetable determinant of different metaboli
Externí odkaz:
https://doaj.org/article/0f8fe7450b4e4f25a3960cce038a7ad3
Autor:
Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle AC Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia
Publikováno v:
eLife, Vol 11 (2022)
Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheless, whether
Externí odkaz:
https://doaj.org/article/247af8afae3341a19c89d1bd9c2e8c96
Autor:
Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflict
Externí odkaz:
https://doaj.org/article/bc991f9e636e41c6936e5e05d890d9b1
Publikováno v:
Journal of Pediatric Ophthalmology & Strabismus. 60:52-59
Purpose: To explore the clinical features of laser pointer–related retinal injuries among children and gain insight into the general public awareness around laser pointer use. Methods: This was a retrospective case series of 9 children (12 eyes) wi
Autor:
Alan Cunningham, Ajay Kotagiri
Publikováno v:
BMC Ophthalmology, Vol 18, Iss S1, Pp 1-7 (2018)
Abstract Background Dense Deposit Disease is a rare condition affecting the Bruch’s membrane and the glomerular basement membrane. We report the progression of the ocular manifestations over a 30 year follow up period, longer than any previous repo
Externí odkaz:
https://doaj.org/article/40e8bc26d1f944329737d23367564082
Autor:
Joanna S. Denton, Debra A. Bostick, Sergei F. Boulyga, J. Alan Cunningham, Ike Dimayuga, Cole R. Hexel, Joe Hiess, Slobodan V. Jovanovic, Philip Kaye, Tara Kell, Fiona Kelly, William Kinman, Stephen Kiser, Rachel E. Lindvall, Zsuzsanna Macsik, Benjamin T. Manard, Klaus Mayer, Jean-Francois Mercier, Pavel Samuleev, Patrick R. B. Saull, Youqing Shi, Robert. E. Steiner, Brian W. Ticknor, Marina Totland, Zsolt Varga, Maria Wallenius, E. Miller Wylie
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry.
Autor:
Alan Cunningham, Ayşegül Erdem, Islam Alshamleh, Marjan Geugien, Maurien Pruis, Diego Antonio Pereira-Martins, Fiona A. J. van den Heuvel, Albertus T. J. Wierenga, Hilde ten Berge, Robin Dennebos, Vincent van den Boom, Shanna M. Hogeling, Isabel Weinhäuser, Ruth Knops, Pim de Blaauw, M. Rebecca Heiner-Fokkema, Carolien Woolthuis, Ulrich L. Günther, Eduardo M. Rego, Joost H. A. Martens, Joop H. Jansen, Harald Schwalbe, Gerwin Huls, Jan Jacob Schuringa
Publikováno v:
Blood, 140, 19, pp. 2037-2052
Blood, 140(19). AMER SOC HEMATOLOGY
Blood, 140, 2037-2052
Blood, 140(19). AMER SOC HEMATOLOGY
Blood, 140, 2037-2052
Targeting altered tumor cell metabolism might provide an attractive opportunity for patients with acute myeloid leukemia (AML). An amino acid dropout screen on primary leukemic stem cells and progenitor populations revealed a number of amino acid dep
Autor:
Shanna M Hogeling, Roos Houtsma, Nisha K Van Der Meer, Salam A. Assi, Paulynn Chin, Alan Cunningham, Peter Keane, Dominique Sternadt Alexandre Ramos, Lieve Oudejans, Gerwin A. Huls, Constance Bonifer, Jan Jacob Schuringa
Publikováno v:
Blood. 140:5844-5845
Autor:
Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle AC Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8727f2ae9314465ba307e260125acf7c
https://doi.org/10.7554/elife.75908.sa2
https://doi.org/10.7554/elife.75908.sa2