Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma

Autor: Celeste M. Porsbjerg, John Townend, Celine Bergeron, George C. Christoff, Gregory P. Katsoulotos, Désirée Larenas-Linnemann, Trung N. Tran, Riyad Al-Lehebi, Sinthia Z. Bosnic-Anticevich, John Busby, Mark Hew, Konstantinos Kostikas, Nikolaos G. Papadopoulos, Paul E. Pfeffer, Todor A. Popov, Chin Kook Rhee, Mohsen Sadatsafavi, Ming-Ju Tsai, Charlotte Suppli Ulrik, Mona Al-Ahmad, Alan Altraja, Aaron Beastall, Lakmini Bulathsinhala, Victoria Carter, Borja G. Cosio, Kirsty Fletton, Susanne Hansen, Liam G. Heaney, Richard B. Hubbard, Piotr Kuna, Ruth B. Murray, Tatsuya Nagano, Laura Pini, Diana Jimena Cano Rosales, Florence Schleich, Michael E. Wechsler, Rita Amaral, Arnaud Bourdin, Guy G. Brusselle, Wenjia Chen, Li Ping Chung, Eve Denton, Joao A. Fonseca, Flavia Hoyte, David J. Jackson, Rohit Katial, Bruce J. Kirenga, Mariko Siyue Koh, Agnieszka Ławkiedraj, Lauri Lehtimäki, Mei Fong Liew, Bassam Mahboub, Neil Martin, Andrew N. Menzies-Gow, Pee Hwee Pang, Andriana I. Papaioannou, Pujan H. Patel, Luis Perez-De-Llano, Matthew J. Peters, Luisa Ricciardi, Bellanid Rodríguez-Cáceres, Ivan Solarte, Tunn Ren Tay, Carlos A. Torres-Duque, Eileen Wang, Martina Zappa, John Abisheganaden, Karin Dahl Assing, Richard W. Costello, Peter G. Gibson, Enrico Heffler, Jorge Máspero, Stefania Nicola, Diahn-Warng Perng (Steve), Francesca Puggioni, Sundeep Salvi, Chau-Chyun Sheu, Concetta Sirena, Camille Taillé, Tze Lee Tan, Leif Bjermer, Giorgio Walter Canonica, Takashi Iwanaga, Libardo Jiménez-Maldonado, Christian Taube, Luisa Brussino, David B. Price

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundTo date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.AimTo elucidate the a

Externí odkaz: https://doaj.org/article/785ec080909546459be89268c120b71f

Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort

Autor: Susanne Hansen, Anna von Bülow, Patrik Sandin, Olivia Ernstsson, Christer Janson, Lauri Lehtimäki, Hannu Kankaanranta, Charlotte Ulrik, Bernt Bøgvald Aarli, Hanna Fues Wahl, Kirk Geale, Sheila Tuyet Tang, Maija Wolf, Tom Larsen, Alan Altraja, Helena Backman, Maritta Kilpeläinen, Arja Viinanen, Dora Ludviksdottir, Paula Kauppi, Asger Sverrild, Sverre Lehmann, Vibeke Backer, Valentyna Yasinska, Tina Skjold, Jussi Karjalainen, Apostolos Bossios, Celeste Porsbjerg

Publikováno v: ERJ Open Research, Vol 9, Iss 2 (2023)

Background Real-life evidence on prevalence and management of severe asthma is limited. Nationwide population registries across the Nordic countries provide unique opportunities to describe prevalence and management patterns of severe asthma at popul

Externí odkaz: https://doaj.org/article/53bc481cf3ba47f2b816ed9063f899ad

Eosinophilic airway diseases: basic science, clinical manifestations and future challenges

Autor: Christer Janson, Leif Bjermer, Lauri Lehtimäki, Hannu Kankaanranta, Jussi Karjalainen, Alan Altraja, Valentyna Yasinska, Bernt Aarli, Madeleine Rådinger, Johan Hellgren, Magnus Lofdahl, Peter H Howarth, Celeste Porsbjerg

Publikováno v: European Clinical Respiratory Journal, Vol 9, Iss 1 (2022)

Eosinophils have a broad range of functions, both homeostatic and pathological, mediated through an array of cell surface receptors and specific secretory granules that promote interactions with their microenvironment. Eosinophil development, differe

Externí odkaz: https://doaj.org/article/cafaba4b62ec41c0be49070ccc7baacd

A successful introduction to a non-expert setting of the thin-layer agar Colour Test as an indirect phenotypic drug susceptibility test for Mycobacterium tuberculosis

Autor: Kadri Klaos, Anna Agejeva, Tiina Kummik, Sirje Laks, Olesja Remets, Sirje Sasi, Anneli Tann, Piret Viiklepp, Alan Altraja

Publikováno v: International Journal of Infectious Diseases, Vol 104, Iss , Pp 19-26 (2021)

Objectives: We evaluated the performance of the MDR/XDR-TB Colour Test (CT) as an in-house thin-layer agar-based indirect drug susceptibility test (DST) for Mycobacterium tuberculosis (MTB) in a non-expert setting in Estonia. Methods: After 2 days of

Externí odkaz: https://doaj.org/article/f7838f35f7ef4cec8aabe9c913994f73

International severe asthma registry (ISAR): protocol for a global registry

Autor: J. Mark FitzGerald, Trung N. Tran, Marianna Alacqua, Alan Altraja, Vibeke Backer, Leif Bjermer, Unnur Bjornsdottir, Arnaud Bourdin, Guy Brusselle, Lakmini Bulathsinhala, John Busby, Giorgio W. Canonica, Victoria Carter, Isha Chaudhry, You Sook Cho, George Christoff, Borja G. Cosio, Richard W. Costello, Neva Eleangovan, Peter G. Gibson, Liam G. Heaney, Enrico Heffler, Mark Hew, Naeimeh Hosseini, Takashi Iwanaga, David J. Jackson, Rupert Jones, Mariko S. Koh, Thao Le, Lauri Lehtimäki, Dora Ludviksdottir, Anke H. Maitland-van der Zee, Andrew Menzies-Gow, Ruth B. Murray, Nikolaos G. Papadopoulos, Luis Perez-de-Llano, Matthew Peters, Paul E. Pfeffer, Todor A. Popov, Celeste M. Porsbjerg, Chris A. Price, Chin K. Rhee, Mohsen Sadatsafavi, Yuji Tohda, Eileen Wang, Michael E. Wechsler, James Zangrilli, David B. Price

Publikováno v: BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-14 (2020)

Abstract Background Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of s

Externí odkaz: https://doaj.org/article/e54dcc26c659484a946707247a18094b