Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Alan, Aderem"'
Autor:
Sara B. Cohen, Courtney R. Plumlee, Lindsay Engels, Dat Mai, Tara A. Murray, Ana N. Jahn, Bridget Alexander, Jared L. Delahaye, Lauren M. Cross, Karolina Maciag, Sam Schrader, Kaitlin Durga, Elizabeth S. Gold, Alan Aderem, Michael Y. Gerner, Benjamin H. Gern, Alan H. Diercks, Kevin B. Urdahl
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
To investigate how host and pathogen diversity govern immunity against Mycobacterium tuberculosis (Mtb), we performed a large-scale screen of vaccine-mediated protection against aerosol Mtb infection using three inbred mouse strains [C57BL/6 (B6), C3
Externí odkaz:
https://doaj.org/article/8f1d5d9be6814725a222414224aa913c
Autor:
Dat Mai, Ana Jahn, Tara Murray, Michael Morikubo, Pamelia N. Lim, Maritza M. Cervantes, Linh K. Pham, Johannes Nemeth, Kevin Urdahl, Alan H. Diercks, Alan Aderem, Alissa C. Rothchild
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/a8b5eeaaa33d439183f3c3f68c960c42
Autor:
Daniel Greiner, Tiana M. Scott, Gregory S. Olson, Alan Aderem, Minna Roh‐Johnson, Jarrod S. Johnson
Publikováno v:
Current protocols. 2(8)
Myeloid dendritic cells (DCs) and macrophages are mononuclear phagocytes with key roles in the immune system. As antigen-presenting cells, they link innate detection of microbes with programming adaptive immune responses. Myeloid DCs and macrophages
Autor:
Johannes Nemeth, Gregory S Olson, Alissa C Rothchild, Ana N Jahn, Dat Mai, Fergal J Duffy, Jared L Delahaye, Sanjay Srivatsan, Courtney R Plumlee, Kevin B Urdahl, Elizabeth S Gold, Alan Aderem, Alan H Diercks
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008655 (2020)
Progress in tuberculosis vaccine development is hampered by an incomplete understanding of the immune mechanisms that protect against infection with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. Although the M72/ASOE1 trial y
Externí odkaz:
https://doaj.org/article/8b125e515468469890da614482c96ca1
Publikováno v:
Bio-Protocol, Vol 10, Iss 10 (2020)
Mycobacterium tuberculosis (Mtb) is transmitted by aerosol and can cause serious bacterial infection in the lung that can be fatal if left untreated. Mtb is now the leading cause of death worldwide by an infectious agent. Characterizing the early eve
Externí odkaz:
https://doaj.org/article/2bbc096a1ded4ccead74fd4e8b946e86
Autor:
Ying Du, Ethan G. Thompson, Julius Muller, Joseph Valvo, Jackie Braun, Smitha Shankar, Robert A. van den Berg, Erik Jongert, Drew Dover, Jerald Sadoff, Jenny Hendriks, Malcolm J. Gardner, W. Ripley Ballou, Jason A. Regules, Robbert van der Most, Alan Aderem, Christian F. Ockenhouse, Adrian V. Hill, Ulrike Wille-Reece, Daniel E. Zak
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The RTS,S/AS01 vaccine provides partial protection against Plasmodium falciparum infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associ
Externí odkaz:
https://doaj.org/article/7307d7b8880a4c2faaa0b56834a30238
Autor:
Jarrod S. Johnson, Nicholas De Veaux, Alexander W. Rives, Xavier Lahaye, Sasha Y. Lucas, Brieuc P. Perot, Marine Luka, Victor Garcia-Paredes, Lynn M. Amon, Aaron Watters, Ghaith Abdessalem, Alan Aderem, Nicolas Manel, Dan R. Littman, Richard Bonneau, Mickaël M. Ménager
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 914-931.e9 (2020)
Summary: Transcriptional programming of the innate immune response is pivotal for host protection. However, the transcriptional mechanisms that link pathogen sensing with innate activation remain poorly understood. During HIV-1 infection, human dendr
Externí odkaz:
https://doaj.org/article/3aa4ead211ed47e6b1d84ce959cdb319
Autor:
Joseph R. Francica, Daniel E. Zak, Caitlyn Linde, Emilio Siena, Carrie Johnson, Michal Juraska, Nicole L. Yates, Bronwyn Gunn, Ennio De Gregorio, Barbara J. Flynn, Nicholas M. Valiante, Padma Malyala, Susan W. Barnett, Pampi Sarkar, Manmohan Singh, Siddhartha Jain, Margaret Ackerman, Munir Alam, Guido Ferrari, Andres Salazar, Georgia D. Tomaras, Derek T. O'Hagan, Alan Aderem, Galit Alter, Robert A. Seder
Publikováno v:
Blood Advances, Vol 1, Iss 25, Pp 2329-2342 (2017)
Abstract: Adjuvants have a critical role for improving vaccine efficacy against many pathogens, including HIV. Here, using transcriptional RNA profiling and systems serology, we assessed how distinct innate pathways altered HIV-specific antibody resp
Externí odkaz:
https://doaj.org/article/412a4dcf39fe46fa94a258dc035552c8
Autor:
Daniel F. Hoft, Azra Blazevic, Asmir Selimovic, Aldin Turan, Jan Tennant, Getahun Abate, John Fulkerson, Daniel E. Zak, Robert Walker, Bruce McClain, Jerry Sadoff, Judy Scott, Barbara Shepherd, Jasur Ishmukhamedov, David A. Hokey, Veerabadran Dheenadhayalan, Smitha Shankar, Lynn Amon, Garnet Navarro, Rebecca Podyminogin, Alan Aderem, Lew Barker, Michael Brennan, Robert S. Wallis, Anne A. Gershon, Michael D. Gershon, Sharon Steinberg
Publikováno v:
EBioMedicine, Vol 7, Iss C, Pp 278-286 (2016)
Background: We report a first-in-human trial evaluating safety and immunogenicity of a recombinant BCG, AERAS-422, over-expressing TB antigens Ag85A, Ag85B, and Rv3407 and expressing mutant perfringolysin. Methods: This was a randomized, double-blind
Externí odkaz:
https://doaj.org/article/247fad6c17484ca8917acc90c57cd726
Autor:
Thomas J Scriba, Adam Penn-Nicholson, Smitha Shankar, Tom Hraha, Ethan G Thompson, David Sterling, Elisa Nemes, Fatoumatta Darboe, Sara Suliman, Lynn M Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, John L Johnson, W Henry Boom, Mark Hatherill, Joe Valvo, Mary Ann De Groote, Urs A Ochsner, Alan Aderem, Willem A Hanekom, Daniel E Zak, other members of the ACS cohort study team
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006687 (2017)
Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis infection to pulmonary tuberculosis disease in humans remains limited. To define such mechanisms, we followed M. tuberculosis-infected adolescents longitudinally.
Externí odkaz:
https://doaj.org/article/1123ad39de7647288ab1f6500ddd06d0