Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alamelu G. Bharadwaj"'
Autor:
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie‐Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 91-112 (2024)
Aldehyde dehydrogenase 1A3 (ALDH1A3) is a cancer stem cell marker that promotes metastasis. Triple‐negative breast cancer (TNBC) progression has been linked to ALDH1A3‐induced gene expression changes. To investigate the mechanism of ALDH1A3‐med
Externí odkaz:
https://doaj.org/article/3963ad169532432cb23f181c5b3a6969
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 866 (2024)
Calreticulin (CRT) is an intrinsically disordered multifunctional protein that plays essential roles intra-and extra-cellularly. The Michalak laboratory has proposed that CRT was initially identified in 1974 by the MacLennan laboratory as the high-af
Externí odkaz:
https://doaj.org/article/b5bed64e0d4f4a8c9dccaa4649136d7b
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1450 (2023)
S100A10 (p11, annexin II light chain, calpactin light chain) is a multifunctional protein with a wide range of physiological activity. S100A10 is unique among the S100 family members of proteins since it does not bind to Ca2+, despite its sequence an
Externí odkaz:
https://doaj.org/article/eb38d3c5f2a14eeb92a4ab8d3379ed66
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1772 (2021)
The generation of the serine protease plasmin is initiated by the binding of its zymogenic precursor, plasminogen, to cell surface receptors. The proteolytic activity of plasmin, generated at the cell surface, plays a crucial role in several physiolo
Externí odkaz:
https://doaj.org/article/49058e46bd684f24b29a8e3ad989923c
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 1772, p 1772 (2021)
Biomolecules, Vol 11, Iss 1772, p 1772 (2021)
The generation of the serine protease plasmin is initiated by the binding of its zymogenic precursor, plasminogen, to cell surface receptors. The proteolytic activity of plasmin, generated at the cell surface, plays a crucial role in several physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a25a22554b889942e5b74deefe84d6
https://pubmed.ncbi.nlm.nih.gov/34944416
https://pubmed.ncbi.nlm.nih.gov/34944416
Publikováno v:
Cancers
Cancers, Vol 13, Iss 1838, p 1838 (2021)
Cancers, Vol 13, Iss 1838, p 1838 (2021)
Simple Summary In this review, we present a detailed discussion of how the plasminogen-activation system is utilized by tumor cells in their unrelenting attack on the tissues surrounding them. Plasmin is an enzyme which is responsible for digesting s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8936c0d3fe27833e8854e5c7a9ac0f0b
http://europepmc.org/articles/PMC8070608
http://europepmc.org/articles/PMC8070608
Autor:
David M. Waisman, Rong-Zong Liu, Paola Marcato, Lynn Thomas, Roseline Godbout, Penelope J. Barnes, Patricia Colp, Paola A. Marignani, Alamelu G. Bharadwaj, Catherine K.L. Too, Ryan W. Holloway, Margaret L. Dahn
Publikováno v:
Cancers, Vol 12, Iss 3673, p 3673 (2020)
Cancers
Volume 12
Issue 12
Cancers
Volume 12
Issue 12
S100A10 (p11) is a plasminogen receptor that regulates cellular plasmin generation by cancer cells. In the current study, we used the MMTV-PyMT mouse breast cancer model, patient tumor microarray, and immunohistochemical (IHC) analysis to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b2ba36e8656d2e60b5f0932b17a137
https://www.mdpi.com/2072-6694/12/12/3673
https://www.mdpi.com/2072-6694/12/12/3673
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports
Scientific Reports
Cancer dissemination is initiated by the movement of cells into the vasculature which has been reported to be triggered by EMT (epithelial to mesenchymal transition). Cellular dissemination also requires proteases that remodel the extracellular matri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c395605e8a2abd7117145f2a3110b96
https://doi.org/10.1038/s41598-020-68535-9
https://doi.org/10.1038/s41598-020-68535-9
Autor:
Mushfiqur Rahman, David M. Waisman, Ryan W. Holloway, Paola A. Marignani, Alamelu G. Bharadwaj, Paola Marcato, Alejandro Cohen, Margaret L. Thomas
Publikováno v:
Cell Death and Disease, Vol 9, Iss 9, Pp 1-15 (2018)
Cell Death & Disease
Cell Death & Disease
S100A10 (p11), a member of the S100 family of small dimeric EF-hand-type Ca2+-binding proteins, plays a role in a variety of both intracellular and extracellular processes. Previous studies have suggested that p11 is intrinsically unstable and requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a496bb357e78aff1bab244dadc2700
http://link.springer.com/article/10.1038/s41419-018-0954-6
http://link.springer.com/article/10.1038/s41419-018-0954-6
Autor:
David M. Waisman, Moamen Bydoun, Katy A. Garant, Patrick W. K. Lee, Paul A. O'Connell, Alamelu G. Bharadwaj, Patricia A. Madureira
Publikováno v:
Oncotarget
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Madureira, P A, Bharadwaj, A G, Bydoun, M, Garant, K, O'Connell, P, Lee, P & Waisman, D M 2016, ' Cell surface protease activation during RAS transformation : critical role of the plasminogen receptor, S100A10 ', Oncotarget, vol. 7, no. 30, pp. 47720-47737 . https://doi.org/10.18632/oncotarget.10279
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Madureira, P A, Bharadwaj, A G, Bydoun, M, Garant, K, O'Connell, P, Lee, P & Waisman, D M 2016, ' Cell surface protease activation during RAS transformation : critical role of the plasminogen receptor, S100A10 ', Oncotarget, vol. 7, no. 30, pp. 47720-47737 . https://doi.org/10.18632/oncotarget.10279
// Patricia A. Madureira 1 , Alamelu G. Bharadwaj 2 , Moamen Bydoun 3 , Katy Garant 3 , Paul O'Connell 2 , Patrick Lee 3 , David M. Waisman 2, 3 1 Centre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Faro, Portugal 2 Depa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6f1de22efff3ae49c01579669f1541
https://doi.org/10.18632/oncotarget.10279
https://doi.org/10.18632/oncotarget.10279