Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

Autor: Green, Cara L., Trautman, Michaela E., Chaiyakul, Krittisak, Jain, Raghav, Alam, Yasmine H., Babygirija, Reji, Pak, Heidi H., Sonsalla, Michelle M., Calubag, Mariah F., Yeh, Chung-Yang, Bleicher, Anneliese, Novak, Grace, Liu, Teresa T., Newman, Sarah, Ricke, Will A., Matkowskyj, Kristina A., Ong, Irene M., Jang, Cholsoon, Simcox, Judith, Lamming, Dudley W.

Publikováno v: In Cell Metabolism 7 November 2023 35(11):1976-1995

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Dietary isoleucine content defines the metabolic and molecular response to a Western diet.

Autor: Trautman ME; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA.; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI., Green CL; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA., MacArthur MR; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA., Chaiyakul K; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WI 53705, USA., Alam YH; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Yeh CY; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA., Babygirija R; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA.; Cell and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA., James I; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Gilpin M; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Zelenovskiy E; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA., Green M; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA., Marshall RN; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA., Sonsalla MM; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA.; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706, USA., Flores V; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA.; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI., Simcox JA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706, USA., Ong IM; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WI 53705, USA., Malecki KC; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA., Jang C; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Lamming DW; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 USA.; Nutrition and Metabolism Graduate Program, University of Wisconsin-Madison, Madison, WI.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53705, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 03. Date of Electronic Publication: 2024 Jun 03.