Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Alaji Bah"'
Autor:
Daniyal Tariq, Nicole Maurici, Bradley M Bartholomai, Siddarth Chandrasekaran, Jay C Dunlap, Alaji Bah, Brian R Crane
Publikováno v:
eLife, Vol 12 (2024)
Circadian clocks are composed of transcription-translation negative feedback loops that pace rhythms of gene expression to the diurnal cycle. In the filamentous fungus Neurospora crassa, the proteins Frequency (FRQ), the FRQ-interacting RNA helicase
Externí odkaz:
https://doaj.org/article/cad2483ee3074190926abe1e0ea9cbce
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-19 (2021)
Abstract Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis i
Externí odkaz:
https://doaj.org/article/0b134cc45516492eb45b013d718ebd29
Autor:
Jennifer E. Dawson, Alaji Bah, Zhenfu Zhang, Robert M. Vernon, Hong Lin, P. Andrew Chong, Manasvi Vanama, Nahum Sonenberg, Claudiu C. Gradinaru, Julie D. Forman-Kay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Phosphorylation of eIF4E binding proteins (4E-BPs) controls their folding and regulates cap-dependent translation. Here, the authors show that phosphorylation of the C-terminal disordered region stabilizes the non-cooperatively folded 4E-BP domain to
Externí odkaz:
https://doaj.org/article/57e3644d3e9b45b39d26e1a240848dcf
Autor:
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 12, Pp n/a-n/a (2021)
Abstract Regulatory T cells (Tregs) play an important role in controlling autoimmunity and limiting tissue damage and inflammation. IL2‐inducible T cell kinase (Itk) is part of the Tec family of tyrosine kinases and is a critical component of T cel
Externí odkaz:
https://doaj.org/article/4b2076bcc0cb4825ad858a8c9823abea
Autor:
Leonardo G. Dettori, Diego Torrejon, Arijita Chakraborty, Arijit Dutta, Mohamed Mohamed, Csaba Papp, Vladimir A. Kuznetsov, Patrick Sung, Wenyi Feng, Alaji Bah
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
R-loops are non-canonical, three-stranded nucleic acid structures composed of a DNA:RNA hybrid, a displaced single-stranded (ss)DNA, and a trailing ssRNA overhang. R-loops perform critical biological functions under both normal and disease conditions
Externí odkaz:
https://doaj.org/article/3bb66076549b4dee8876f201be381aaa
Autor:
Mahinbanu Mammadli, Weishan Huang, Rebecca Harris, Hui Xiong, Samuel Weeks, Adriana May, Teresa Gentile, Jessica Henty-Ridilla, Adam T. Waickman, Avery August, Alaji Bah, Mobin Karimi
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102286- (2021)
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for hematological malignancies, due to graft-versus-leukemia (GVL) activity mediated by alloreactive donor T cells. However, graft-versus-host disease (GVHD
Externí odkaz:
https://doaj.org/article/9117c9a8368744a7a223a2f8a4f036fd
Autor:
Mahinbanu Mammadli, Weishan Huang, Rebecca Harris, Aisha Sultana, Ying Cheng, Wei Tong, Jeffery Pu, Teresa Gentile, Shanti Dsouza, Qi Yang, Alaji Bah, Avery August, Mobin Karimi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Allogeneic hematopoietic stem cell transplantation is a potentially curative procedure for many malignant diseases. Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. Donor T cells also contribute to graft-versus-host di
Externí odkaz:
https://doaj.org/article/c0a291f10bb64bf48c6e7ee416cf454c
Autor:
David P. Scanlon, Alaji Bah, Mickaël Krzeminski, Wenbo Zhang, Heather L. Leduc-Pessah, Yi Na Dong, Julie D. Forman-Kay, Michael W. Salter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a proc
Externí odkaz:
https://doaj.org/article/50c00c45052a4a68a4e123d4c54090df
Autor:
Veronika Csizmok, Stephen Orlicky, Jing Cheng, Jianhui Song, Alaji Bah, Neda Delgoshaie, Hong Lin, Tanja Mittag, Frank Sicheri, Hue Sun Chan, Mike Tyers, Julie D. Forman-Kay
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The WD40 domain of the SCFCdc4ubiquitin ligase targets substrates via multiple phosphorylated degron motifs. The authors define a second degron-binding WD40 pocket that imparts a negative allosteric effect on binding to the primary pocket, and thereb
Externí odkaz:
https://doaj.org/article/3ceb544c2e084e38929cafb11be01401
Autor:
Alexander J. Baker-Williams, Fiza Hashmi, Marek A. Budzyński, Mark R. Woodford, Stephanie Gleicher, Samu V. Himanen, Alan M. Makedon, Derek Friedman, Stephanie Cortes, Sara Namek, William G. Stetler-Stevenson, Gennady Bratslavsky, Alaji Bah, Mehdi Mollapour, Lea Sistonen, Dimitra Bourboulia
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1894-1906.e6 (2019)
Summary: The extracellular molecular chaperone heat shock protein 90 (eHSP90) stabilizes protease client the matrix metalloproteinase 2 (MMP2), leading to tumor cell invasion. Although co-chaperones are critical modulators of intracellular HSP90:clie
Externí odkaz:
https://doaj.org/article/5c2fb5f7bb824f3faae72044a1736056