Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Alaina M, Reagan"'
1
Akademický článek
Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice
Autor: Adrian L. Oblak, Kevin P. Kotredes, Ravi S. Pandey, Alaina M. Reagan, Cynthia Ingraham, Bridget Perkins, Christopher Lloyd, Deborah Baker, Peter B. Lin, Disha M. Soni, Andy P. Tsai, Scott A. Persohn, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Jill A. Meyer, Johnathan S. Peters, Lucas L. Figueiredo, Michael Sasner, Paul R. Territo, Stacey J. Sukoff Rizzo, Gregory W. Carter, Bruce T. Lamb, Gareth R. Howell
Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)
Obesity is recognized as a significant risk factor for Alzheimer’s disease (AD). Studies have supported the notion that obesity accelerates AD-related pathophysiology in mouse models of AD. The majority of studies, to date, have focused on the use
Externí odkaz: https://doaj.org/article/b6814a937f1741338ed611ffbc142ff3
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2
Akademický článek
Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity
Autor: Hongtian Yang, Leah C. Graham, Alaina M. Reagan, Weronika A. Grabowska, William H. Schott, Gareth R. Howell
Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-18 (2019)
Abstract Background Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly. It is increasingly recog
Externí odkaz: https://doaj.org/article/9ac362a21d3b4c8ab79a191344112566
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3
The
Autor: Alaina M, Reagan, Karen E, Christensen, Leah C, Graham, Amanda A, Bedwell, Kierra, Eldridge, Rachael, Speedy, Lucas L, Figueiredo, Scott C, Persohn, Teodoro, Bottiglieri, Kwangsik, Nho, Michael, Sasner, Paul R, Territo, Rima, Rozen, Gareth R, Howell
Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 42(12)
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer's disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate red
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b777dfaf3b327ed352bb333f71cdea06
https://pubmed.ncbi.nlm.nih.gov/36050860
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4
The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice
Autor: Alaina M Reagan, Karen E Christensen, Leah C Graham, Amanda A Bedwell, Kierra Eldridge, Rachael Speedy, Lucas L Figueiredo, Scott C Persohn, Teodoro Bottiglieri, Kwangsik Nho, Michael Sasner, Paul R Territo, Rima Rozen, Gareth R Howell
Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 42:2333-2350
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7482d7ee3029e817139cb404a3264cea
https://doi.org/10.1177/0271678x221122644
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5
Improving mouse models for the study of Alzheimer's disease
Autor: Alaina M, Reagan, Kristen D, Onos, Sarah E, Heuer, Michael, Sasner, Gareth R, Howell
Publikováno v: Current topics in developmental biology. 148
Alzheimer's disease (AD) is a complex neurodegenerative disease whose risk is influenced by genetic and environmental factors. Although a number of pathological hallmarks have been extensively studied over the last several decades, a complete picture
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3104d768bb4755f8675e1edf81945ca
https://pubmed.ncbi.nlm.nih.gov/35461569
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9
Vaccine-induced Antibodies Target Sequestered Viral Antigens to Prevent Ocular HSV-1 Pathogenesis, Preserve Vision, and Preempt Productive Neuronal Infection
Autor: Virginie Sjoelund, Daniel J.J. Carr, Danielle M. Robertson, Chelsea M. Larabee, Alaina M. Reagan, Joshua F. Hendrix, Derek J. Royer
Publikováno v: Mucosal immunology
The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bffb3368c58f7358fb8dfbf7a30f46
http://europepmc.org/articles/PMC6462227
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