Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Alaina Howe"'
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Akademický článek
Two diverse carriers are better than one: A case study in α‐particle therapy for prostate specific membrane antigen‐expressing prostate cancers
Autor: Dominick Salerno, Alaina Howe, Omkar Bhatavdekar, Anders Josefsson, Jesus Pacheco‐Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, Stavroula Sofou
Publikováno v: Bioengineering & Translational Medicine, Vol 7, Iss 2, Pp n/a-n/a (2022)
Abstract Partial and/or heterogeneous irradiation of established (i.e., large, vascularized) tumors by α‐particles that exhibit only a 4–5 cell‐diameter range in tissue, limits the therapeutic effect, since regions not being hit by the high en
Externí odkaz: https://doaj.org/article/f3d7177fd9af4ec7b084eb2668ffc9e0
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2
Combination of Carriers with Complementary Intratumoral Microdistributions of Delivered α-Particles May Realize the Promise for 225Ac in Large, Solid Tumors
Autor: Stavroula Sofou, Alaina Howe, Anders Josefsson, Zaver M. Bhujwalla, Jesús Pacheco-Torres, Kathleen L. Gabrielson, Dominick Salerno, George Sgouros, Omkar Bhatavdekar
Publikováno v: J Nucl Med
Alpha-particle radiotherapy has already been shown to be impervious to most resistance mechanisms. However, in established (i.e. large, vascularized) soft-tissue lesions, the diffusion-limited penetration depths of radiolabeled antibodies and/or nano
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b597ddc70809a839bc8c0f292b91d112
https://doi.org/10.2967/jnumed.121.262992
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4
Two diverse carriers are better than one: A case study in α-particle therapy for prostate specific membrane antigen-expressing prostate cancers
Autor: Zaver M. Bhujwalla, Stavroula Sofou, Kathleen L. Gabrielson, Jesus Pacheco-Torres, Omkar Bhatavdekar, Anders Josefsson, Alaina Howe, Dominick Salerno
Publikováno v: Bioengineeringtranslational medicine. 7(2)
Partial and/or heterogeneous irradiation of established (i.e., large, vascularized) tumors by α-particles that exhibit only a 4-5 cell-diameter range in tissue, limits the therapeutic effect, since regions not being hit by the high energy α-particl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260f0961caee85f7e39e01126a62cc18
https://pubmed.ncbi.nlm.nih.gov/35600657
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5
Growth of Metastatic Triple-Negative Breast Cancer Is Inhibited by Deep Tumor-Penetrating and Slow Tumor-Clearing Chemotherapy: The Case of Tumor-Adhering Liposomes with Interstitial Drug Release
Autor: Stavroula Sofou, Dominick Salerno, Sally Stras, Alaina Howe, Aprameya Prasad, Omkar Bhatavdekar
Publikováno v: Molecular Pharmaceutics. 17:118-131
The poor prognosis of triple-negative breast cancer (TNBC) is attributed largely to the lack of tumor-selective therapeutic modalities that effectively deliver lethal doses at the sites of metastatic disease. Tumor-selective drug delivery strategies
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d282331339a0d16315b2315871481063
https://doi.org/10.1021/acs.molpharmaceut.9b00812
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7
Interstitial Release of Cisplatin from Triggerable Liposomes Enhances Efficacy against Triple Negative Breast Cancer Solid Tumor Analogues
Autor: Stavroula Sofou, Alaina Howe, Sally Stras, Timothy Holleran
Publikováno v: Molecular pharmaceutics. 13(9)
Liposomal cisplatin, a promising triple negative breast cancer treatment modality, has been shown to decrease toxicities associated with cisplatin's free agent form. However, the heterogeneous intratumoral distributions of the liposomes themselves, c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6f6585289e974f17dc9ed99f423a2b
https://pubmed.ncbi.nlm.nih.gov/27482716
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