Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alain Segonzac"'
Autor:
Jagdev Sidhu, Alain Segonzac, Frank Larsen, Gilles Grollier, Morten Priskorn, Mette Nøhr Poulsen
Publikováno v:
Chirality. 9:686-692
The steady-state pharmacokinetics in serum and urine of the enantiomers of citalopram and its metabolites, demethylcitalopram (DCT) and didemethylcitalopram (DDCT), were investigated after multiple doses of rac-citalopram for 21 consecutive days (40
Publikováno v:
Journal of Neurochemistry. 45:249-256
5-Methoxytryptoline potently inhibits [3H]-imipramine binding to membranes from the cerebral cortex and platelets. Since 5-methoxytryptoline, which appears to occur endogenously with particularly high levels in the human pineal gland, also inhibits 5
Publikováno v:
Journal of neurochemistry. 44(2)
Tricyclic antidepressants and nontricyclic serotonin (5-hydroxytryptamine) uptake blockers monophasically inhibit [3H]imipramine binding in human platelets. Similarly, serotonin and tryptamine inhibit the binding of [3H]imipramine in the low micromol
Publikováno v:
Journal of neurochemistry. 48(2)
Although [3H]imipramine is a selective radioli-gand for the 5-hydroxytryptamine (5-HT) transporter in human platelets, its affinity for binding to the 5-HT transporter complex at 0°C (0.6 nM) is significantly higher than its potency for inhibition o
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 336(1)
5-Methoxytryptoline (5-MeO-TLN, 6-methoxytetrahydro-beta-carboline) inhibits with high affinity [3H]-imipramine binding to the serotonin transporter in platelets. To evaluate whether 5-MeO-TLN is a substrate for the serotonin transporter, the accumul