Výsledky vyhledávání - "Alain Pompon"

Cancer Chemotherapy: A Paclitaxel Prodrug for ADEPT (Antibody‐Directed Enzyme Prodrug Therapy)

Autor: Alain Pompon, Romain Duval, Frédéric Schmidt, Claude Monneret, Ioana Ungureanu

Publikováno v: European Journal of Organic Chemistry. 2001:2129-2134

A glucuronide-based prodrug of paclitaxel (taxol®) has been synthesized for use in antibody-directed enzyme prodrug therapy (ADEPT). This three-component prodrug was obtained by coupling a glucuronyl derivative of N-methylamino 4-nitrophenol (10) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6aac0a96f9ea0ce4f0258ce92ec8c12b
https://doi.org/10.1002/1099-0690(200106)2001:11<2129::aid-ejoc2129>3.0.co

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New bis(SATE) prodrug of AZT 5′‐monophosphate: In vitro anti‐HIV activity, stability, and potential oral absorption

Autor: Jean Louis Imbach, M Shafiee, Christian Périgaud, P. Augustijns, Thierry Lioux, David Egron, G. Van den Mooter, S. Varray, A.-L. Villard, Renaat Kinget, Gilles Gosselin, S. Deferme, Anne-Marie Aubertin, Alain Pompon

Publikováno v: Journal of Pharmaceutical Sciences. 90:448-463

The in vitro anti‐HIV activity, stability, and potential for oral absorption of a phosphotriester derivative of AZT (zidovudine; 3′‐azido‐2′,3′‐deoxythymidine) bearing a new esterase‐labile S ‐acyl‐2‐thioethyl (SATE) group as tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2008528929dc1e47a9415034eebf1b3d
https://doi.org/10.1002/1520-6017(200104)90:4<448::aid-jps1003>3.0.co

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[Untitled]

Autor: G. Valette, Pieter Annaert, P. Augustijns, Jean Louis Imbach, Alain Pompon, Gilles Gosselin, Renaat Kinget, Samira Benzaria, Lieve Naesens, Sigrid Hatse, E. De Clercq, G. Van den Mooter

Publikováno v: Pharmaceutical Research. 15:239-245

Purpose. To evaluate the potential of several bis-ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA, adefovir) to enhance the oral absorption of PMEA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::606154216c25c31397b8e5694bedea2e
https://doi.org/10.1023/a:1011914618109

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The Pronucleotide Approach. I. Synthesis, Anti-HIV Activity and Preliminary Stability Studies of MononucleosideS,S′-Bis(O-acyl-2-oxyethyl) Phosphorodithiolates

Autor: Alain Pompon, André Kirn, Christian Périgaud, Jean Louis Imbach, A-M Aubertin, N. Schlienger, Gilles Gosselin, Isabelle Lefebvre

Publikováno v: Nucleosides and Nucleotides. 16:1321-1324

The synthesis, in vitro anti-HIV activity, and preliminary stability studies of several mononucleoside phosphorodithiolate derivatives incorporating a new kind of bio-labile phosphate-protection, namely 0-pivaloyl-2-oxyethyl, are reported. Our prelim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::877fc1a1f3d65a848b67f468c8af5f90
https://doi.org/10.1080/07328319708006180

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Mononucleoside Phosphotriester Derivatives with S-Acyl-2-thioethyl Bioreversible Phosphate-Protecting Groups: Intracellular Delivery of 3'-Azido-2',3'-dideoxythymidine 5'-Monophosphate

Autor: Gilles Gosselin, Isabelle Lefebvre, Jean-Louis Imbach, Jean-Luc Girardet, Christian Périgaud, Anne-Marie Aubertin, André Kirn, Alain Pompon

Publikováno v: Journal of Medicinal Chemistry. 38:3941-3950

The synthesis, in vitro anti-HIV-1 activity, and decomposition pathways of several mononucleoside phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) incorporating a new kind of carboxylate esterase-labile transient phosphate-protect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f4dc1b2f7ce1441f34fb7d9c241db3
https://doi.org/10.1021/jm00020a007

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Synthesis, Decomposition Pathways and 'In Vitro' Evaluation of Bioreversible Phosphotriesters of Azt

Autor: Christian Périgaud, Anne-Marie Aubertin, André Kirn, Alain Pompon, Isabelle Lefebvre, Gilles Gosselin, Jean-Luc Girardet, Jean-Louis Imbach

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 14:763-766

The synthesis, pharmacokinetic data and biological evaluation of a series of phosphotriesters containing S-acyl-2-thioethyl groups as enzyme-labile phosphate protecting groups and AZT as a model are described. A comparison of pharmacokinetic data and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59774f104f7419e99c605be5fca69d41
https://doi.org/10.1080/15257779508012467

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Decomposition Pathways of the Mono- and Bis(Pivaloyloxymethyl) Esters of Azidothymidine 5′-Monophosphate in Cell Extract and in Tissue Culture Medium: An Application of the ‘on-line ISRP-Cleaning’ HPLC Technique

Autor: S. Kahn, Jean Louis Imbach, D. Farquhar, Alain Pompon, Isabelle Lefebvre

Publikováno v: Antiviral Chemistry and Chemotherapy. 5:91-98

Bis(pivaloyloxymethyl) azidothymidine 5′-monophosphate (piv2-AZTMP) was designed as a cell membrane-permeable precursor of AZTMP. We have reported previously that when incubated with CEM cells deficient in thymidine kinase, piv2-AZTMP gives rise to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f28b4d245455e2750938459fe0045640
https://doi.org/10.1177/095632029400500205

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New Insights into the Resistance of α-Oligonucleotides to Nucleases

Autor: Isabelle Lefebvre, Alain Pompon, Sophie Vichier-Guerre, Jean-Louis Imbach

Publikováno v: Antisense Res Dev
Antisense Res Dev, 1994, 4 (1), pp.9-18

International audience; Several studies have shown that alpha-oligonucleotides (alpha-ONs) are more resistant to degradation by nucleases than are beta-oligonucleotides (beta-ONs), but a few exceptions have been reported. The present work indicates t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38be15e0dada18bf0f153ac29cae5820
https://doi.org/10.1089/ard.1994.4.9

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Rational design of a new series of pronucleotide

Autor: Christian Périgaud, Thierry Beltran, Gilles Gosselin, Jean-Louis Imbach, Alain Pompon, Anne-Marie Aubertin, David Egron, Isabelle Lefebvre

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:1775-1777

A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK �

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https://doi.org/10.1016/s0960-894x(01)00299-2

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