Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alain Philippe Poncelet"'
Autor:
Dushen Chetty, Matthew V. Lorenzi, Sylvie Laquerre, Gaston Stanislas Marcella Diels, Edward C. Lawson, Carol Yanovich, Italo Poggesi, Ivan Somers, Dana Gaffney, Wim Bert Griet Schepens, Hillary Millar, Weimei Sun, Tongfei Wu, Lijs Beke, Viellevoye Marcel, Marc Du Jardin, Petra Vinken, Erika van Heerde, Tinne Verhulst, James P. Edwards, Dirk Brehmer, Barbara Herkert, Geert Mannens, Vineet Pande, Alain Philippe Poncelet, Christopher Moy, An Boeckx, Marc Parade, Thomas Nys, Jan-Willem Thuring, Lieven Meerpoel, Joannes T. M. Linders
Publikováno v:
Cancer Research. 77:DDT02-04
PRMT5 is a type II methyltransferase that specifically adds methyl groups to arginine as a long-lasting post-translational modification. The PRMT5/MEP50 complex regulates a plethora of cellular processes, such as epigenetics and splicing, which are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::987bd807a6c9b8052bd2995cb8ff5795
https://doi.org/10.1158/1538-7445.am2017-ddt02-04
https://doi.org/10.1158/1538-7445.am2017-ddt02-04
Autor:
Scott D. Bembenek, Dmitrii N. Rassokhin, Jeremy Hunt, Edgar Jacoby, Gary Tresadern, Herman van Vlijmen, Christophe Buyck, Berthold Wroblowski, Alain Philippe Poncelet, Jean-Marc Neefs
Publikováno v:
Drug Discovery Today. 20:652-658
The explored kinome was extended with broad profiling using the DiscoveRx and Millipore assay panels. The analysis of the profiling of 3368 selected inhibitors on 456 kinases in the DiscoveRx format delivered several insights. First, the coverage dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd1dfe6699f7c6df87d0c7aa7062b07
https://doi.org/10.1016/j.drudis.2015.01.002
https://doi.org/10.1016/j.drudis.2015.01.002
Autor:
Chi Hung Nguyen, Edward Arnold, Alain Philippe Poncelet, David Grierson, Stephen H. Hughes, Daniel M. Himmel, Said Oumouch, Christophe Meyer, Sophie Coupa, Jerome Guillemont, Abdellah Benjahad, Koen Andries, Kalyan Das, Arthur D. Clark, Csoka Imre Christian Francis
Publikováno v:
Journal of medicinal chemistry
In the treatment of AIDS, the efficacy of all drugs, including non-nucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT), has been limited by the rapid appearance of drug-resistant viruses. Lys103Asn, Tyr181Cys, and Tyr188Leu are some of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83adb8b43e47995658d1595b261bb411
https://doi.org/10.1021/jm0500323
https://doi.org/10.1021/jm0500323
Autor:
Dominique Jean-Pierre Mabire, Alain Philippe Poncelet, Anne Simone Josephine Lesage, Ludy van Beijsterveldt, François Paul Bischoff, Ria Wouters, Christophe Adelinet, Yvan Rene Simonnet, Sophie Coupa, Marc Venet
Publikováno v:
Journal of Medicinal Chemistry. 48:2134-2153
We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC(50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7727d62ed8ca5b6fa5eb08621ef93b
https://doi.org/10.1021/jm049499o
https://doi.org/10.1021/jm049499o
Autor:
Hinrich W. H. Göhlmann, Rudy Edmond Willebrords, Karen Vergauwen, Anil Koul, Luc Vranckx, Alain Philippe Poncelet, Jerome Guillemont, Dirk Bald, Najoua Dendouga, W Balemans, Koen Andries, Ilse Van den Wyngaert
Publikováno v:
Journal of Biological Chemistry, 283, 25273-25280. American Society for Biochemistry and Molecular Biology Inc.
Journal of biological chemistry
Koul, A, Vranckx, L, Dendouga, N, Balemans, W, van den Wyngaert, I, Vergauwen, K, Goehlmann, H W H, Willebrords, R, Poncelet, A, Guillemont, J, Bald, D & Andries, K 2008, ' Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. ', Journal of Biological Chemistry, vol. 283, pp. 25273-25280 . https://doi.org/10.1074/jbc.M803899200
Journal of biological chemistry
Koul, A, Vranckx, L, Dendouga, N, Balemans, W, van den Wyngaert, I, Vergauwen, K, Goehlmann, H W H, Willebrords, R, Poncelet, A, Guillemont, J, Bald, D & Andries, K 2008, ' Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. ', Journal of Biological Chemistry, vol. 283, pp. 25273-25280 . https://doi.org/10.1074/jbc.M803899200
An estimated one-third of the world population is latently infected with Mycobacterium tuberculosis. These nonreplicating, dormant bacilli are tolerant to conventional anti-tuberculosis drugs, such as isoniazid. We recently identified diarylquinoline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6352cd59fe77333b378282647447db8d
https://research.vu.nl/en/publications/5ffab6a5-9a3e-45c4-ad3c-e7cc363c36f7
https://research.vu.nl/en/publications/5ffab6a5-9a3e-45c4-ad3c-e7cc363c36f7
Autor:
Dominique Jean-Pierre Mabire, Koen Andries, Chi Hung Nguyen, Alain Philippe Poncelet, Martine Croisy, Daniel M. Himmel, Christophe Meyer, Claude Monneret, Eddy Arnold, R Pauwels, Marie-Pierre de Béthune, Sophie Coupa, Kalyan Das, David Grierson, Jerome Emile Georges Guillemont, Abdellah Benjahad, Csoka Imre Christian Francis, Emile Bisagni
Publikováno v:
Journal of medicinal chemistry
In a program to optimize the anti-HIV activity of the 4-benzyl and 4-benzoyl-3-dimethylaminopyridinones 9 and 10, lead compounds in a new class of highly potent non-nucleoside type inhibitors of HIV-1 reverse transcriptase, modification of the alkyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267886123a41e6a1498b86721308c0e8
https://pubmed.ncbi.nlm.nih.gov/15771439
https://pubmed.ncbi.nlm.nih.gov/15771439