Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Alain PUISIEUX"'
Autor:
Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of ribosome biogenesis. T
Externí odkaz:
https://doaj.org/article/fb1de5e1e47048e5883db9d402d40dd4
Autor:
Christophe Caux, Stephane Dalle, Arnaud de la Fouchardière, Laurie Tonon, Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Julie Caramel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background The efficacy of immunotherapies in metastatic melanoma depends on a robust T cell infiltration. Oncogenic alterations of tumor cells have been associated to T cell exclusion. Identifying novel cancer cell-intrinsic non-genetic mechanisms o
Externí odkaz:
https://doaj.org/article/0e92f0aaa28a4889857d550e5e0db9eb
Autor:
Roxane M. Pommier, Amélien Sanlaville, Laurie Tonon, Janice Kielbassa, Emilie Thomas, Anthony Ferrari, Anne-Sophie Sertier, Frédéric Hollande, Pierre Martinez, Agnès Tissier, Anne-Pierre Morel, Maria Ouzounova, Alain Puisieux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Claudin-low tumors are a rare aggressive subtype of breast cancers. In this study, the authors use a multiomics approach to demonstrate that these tumors are heterogeneous and comprise three main subgroups that emerge from different evolutionary proc
Externí odkaz:
https://doaj.org/article/fd71c30afd354a149f4036cea3f453ff
Autor:
Mélanie K. Prodhomme, Sarah Péricart, Roxane M. Pommier, Anne-Pierre Morel, Anne-Cécile Brunac, Camille Franchet, Caroline Moyret-Lalle, Pierre Brousset, Alain Puisieux, Jean-Sébastien Hoffmann, Agnès Tissier
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Breast cancer cells frequently acquire mutations in faithful DNA repair genes, as exemplified by BRCA-deficiency. Moreover, overexpression of an inaccurate DNA repair pathway may also be at the origin of the genetic instability arising during the cou
Externí odkaz:
https://doaj.org/article/62d2634ad0974109888f7e46b74d8f22
Publikováno v:
Evolutionary Applications, Vol 12, Iss 5, Pp 1062-1075 (2019)
Abstract Cancer is a potentially lethal disease, in which patients with nearly identical genetic backgrounds can develop a similar pathology through distinct combinations of genetic alterations. We aimed to reconstruct the evolutionary process underl
Externí odkaz:
https://doaj.org/article/29fac551de07476cb1d7cccf3c9951e0
CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity
Autor:
Maha Siouda, Audrey D. Dujardin, Laetitia Barbollat-Boutrand, Marco A. Mendoza-Parra, Benjamin Gibert, Maria Ouzounova, Jebrane Bouaoud, Laurie Tonon, Marie Robert, Jean-Philippe Foy, Vincent Lavergne, Serge N. Manie, Alain Viari, Alain Puisieux, Gabriel Ichim, Hinrich Gronemeyer, Pierre Saintigny, Peter Mulligan
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101141- (2020)
Summary: Epigenetic deregulation of gene transcription is central to cancer cell plasticity and malignant progression but remains poorly understood. We found that the uncharacterized epigenetic factor chromodomain on Y-like 2 (CDYL2) is commonly over
Externí odkaz:
https://doaj.org/article/b54fa9709e804d8693e769f67890345e
Autor:
Laloé Monteiro, Lydie Da Silva, Boris Lipinski, Frédérique Fauvet, Arnaud Vigneron, Alain Puisieux, Pierre Martinez
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Despite advances in single-cell and molecular techniques, it is still unclear how to best quantify phenotypic heterogeneity in cancer cells that evolved beyond normal, known classifications. We present an approach to phenotypically character
Externí odkaz:
https://doaj.org/article/fe3c1ddba5c8444784874712a1924bdc
Autor:
Youenn Drouet, Isabelle Treilleux, Alain Viari, Sophie Léon, Mojgan Devouassoux-Shisheboran, Nicolas Voirin, Christelle de la Fouchardière, Brigitte Manship, Alain Puisieux, Christine Lasset, Caroline Moyret-Lalle
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract After a diagnosis of colorectal cancer (CRC), approximately 50% of patients will present distant metastasis. Although significant progress has been made in treatments, most of them will die from the disease. We investigated the predictive an
Externí odkaz:
https://doaj.org/article/cb2b22da5cf344ad9f5d72362d671496
Autor:
Jean-Philippe Foy, Louis Bazire, Sandra Ortiz-Cuaran, Sophie Deneuve, Janice Kielbassa, Emilie Thomas, Alain Viari, Alain Puisieux, Patrick Goudot, Chloé Bertolus, Nicolas Foray, Youlia Kirova, Pierre Verrelle, Pierre Saintigny
Publikováno v:
BMC Medicine, Vol 15, Iss 1, Pp 1-13 (2017)
Abstract Background Radiotherapy for head and neck squamous cell carcinomas (HNSCC) is associated with a substantial morbidity and inconsistent efficacy. Human papillomavirus (HPV)-positive status is recognized as a marker of increased radiosensitivi
Externí odkaz:
https://doaj.org/article/ec9aa0071c5c410486c5c03ee2b33199
Autor:
Jean-Philippe Foy, Chloé Bertolus, Sandra Ortiz-Cuaran, Marie-Alexandra Albaret, William N Williams, Wenhua Lang, Solène Destandau, Geneviève De Souza, Emilie Sohier, Janice Kielbassa, Emilie Thomas, Sophie Deneuve, Patrick Goudot, Alain Puisieux, Alain Viari, Li Mao, Christophe Caux, SM Lippman, P Saintigny
Publikováno v:
OncoImmunology, Vol 7, Iss 12 (2018)
Oral squamous cell carcinoma (OSCC) is a major cause of cancer-associated morbidity and mortality and may develop from oral premalignant lesions (OPL). An improved molecular classification of OPL may help refining prevention strategies. We identified
Externí odkaz:
https://doaj.org/article/1bf604d2548444788d375e4e5b971c17