Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Alain P Gobert"'
Autor:
Jia Li, Alan J. Simmons, Caroline V. Hawkins, Sophie Chiron, Marisol A. Ramirez-Solano, Naila Tasneem, Harsimran Kaur, Yanwen Xu, Frank Revetta, Paige N. Vega, Shunxing Bao, Can Cui, Regina N. Tyree, Larry W. Raber, Anna N. Conner, Jennifer M. Pilat, Justin Jacobse, Kara M. McNamara, Margaret M. Allaman, Gabriella A. Raffa, Alain P. Gobert, Mohammad Asim, Jeremy A. Goettel, Yash A. Choksi, Dawn B. Beaulieu, Robin L. Dalal, Sara N. Horst, Baldeep S. Pabla, Yuankai Huo, Bennett A. Landman, Joseph T. Roland, Elizabeth A. Scoville, David A. Schwartz, M. Kay Washington, Yu Shyr, Keith T. Wilson, Lori A. Coburn, Ken S. Lau, Qi Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Crohn’s disease (CD) is a complex chronic inflammatory disorder with both gastrointestinal and extra-intestinal manifestations associated immune dysregulation. Analyzing 202,359 cells from 170 specimens across 83 patients, we identify a di
Externí odkaz:
https://doaj.org/article/0ba81d63e38741479e8c66302f19cf18
Autor:
Kshipra Singh, Nicole T Al-Greene, Thomas G Verriere, Lori A Coburn, Mohammad Asim, Daniel P Barry, Margaret M Allaman, Dana M Hardbower, Alberto G Delgado, M Blanca Piazuelo, Bruce A Vallance, Alain P Gobert, Keith T Wilson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005984 (2016)
Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens. We assessed the role of SLC7A2 in murine infection with Citrobacter
Externí odkaz:
https://doaj.org/article/dde25832be474145b30f534c31096627
Autor:
Priscilla Branchu, Stéphanie Matrat, Marjolaine Vareille, Annie Garrivier, Alexandra Durand, Sébastien Crépin, Josée Harel, Grégory Jubelin, Alain P Gobert
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003874 (2014)
Expression of genes of the locus of enterocyte effacement (LEE) is essential for adherence of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells. Gut factors that may modulate LEE gene expression may therefore influence the outc
Externí odkaz:
https://doaj.org/article/1ffa616a9df540e798bd1aeb8576858d
Autor:
Alain P. Gobert, Jordan Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Caroline V. Hawkins, Kamery J. Williams, Alberto G. Delagado, Raghavendra G. Mirmira, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33838- (2024)
Hypusine is an amino acid synthesized by the enzyme deoxyhypusine synthase (DHPS). It is critical for the activity of eukaryotic translation initiation factor 5A (EIF5A). We reported that hypusination i) in macrophages supports the innate response to
Externí odkaz:
https://doaj.org/article/02fd8b1c2fd24f64a472e36bac86f199
Autor:
Yvonne L. Latour, Kara M. McNamara, Margaret M. Allaman, Daniel P. Barry, Thaddeus M. Smith, Mohammad Asim, Kamery J. Williams, Caroline V. Hawkins, Justin Jacobse, Jeremy A. Goettel, Alberto G. Delgado, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The intestinal immune response is crucial in maintaining a healthy gut, but the enhanced migration of macrophages in response to pathogens is a major contributor to disease pathogenesis. Integrins are ubiquitously expressed cellular receptor
Externí odkaz:
https://doaj.org/article/fb0bf8276c3646598c802c501115e29e
Autor:
Daniel P Barry, Mohammad Asim, Brooks P Scull, M Blanca Piazuelo, Thibaut de Sablet, Nuruddeen D Lewis, Lori A Coburn, Kshipra Singh, Lesley G Ellies, Alain P Gobert, Rupesh Chaturvedi, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29046 (2011)
Once acquired, Helicobacter pylori infection is lifelong due to an inadequate innate and adaptive immune response. Our previous studies indicate that interactions among the various pathways of arginine metabolism in the host are critical determinants
Externí odkaz:
https://doaj.org/article/09ba87fccc7840d89038169ee39687b0
Autor:
Yvonne L. Latour, Margaret M. Allaman, Daniel P. Barry, Thaddeus M. Smith, Kamery J. Williams, Kara M. McNamara, Justin Jacobse, Jeremy A. Goettel, Alberto G. Delgado, M. Blanca Piazuelo, Shilin Zhao, Alain P. Gobert, Keith T. Wilson
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTPathogenic enteric Escherichia coli present a significant burden to global health. Food-borne enteropathogenic E. coli (EPEC) and Shiga toxin-producing E. coli (STEC) utilize attaching and effacing (A/E) lesions and actin-dense pedestal forma
Externí odkaz:
https://doaj.org/article/f9ea48e1d73a40c2ba5b50cc0608468a
Autor:
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, M. Blanca Piazuelo, John A. Rathmacher, Keith T. Wilson
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114092- (2023)
Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric pathogen that is the primary risk factor for carcinogenesis, associated with its induction of inflammation and DNA damage. Dicarbonyl electrophiles are gene
Externí odkaz:
https://doaj.org/article/1f4024028ab047ef81fef71e6a3430e6
Autor:
Yvonne L. Latour, Johanna C. Sierra, Jordan L. Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Thaddeus M. Smith, Kara M. McNamara, Paula B. Luis, Claus Schneider, Justin Jacobse, Jeremy A. Goettel, M. Wade Calcutt, Kristie L. Rose, Kevin L. Schey, Ginger L. Milne, Alberto G. Delgado, M. Blanca Piazuelo, Bindu D. Paul, Solomon H. Snyder, Alain P. Gobert, Keith T. Wilson
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world’s population and causes gastric cancer. Recent studies have highlighted the importance of macrophage imm
Externí odkaz:
https://doaj.org/article/19c8a2f445654133870ff2cc83d6103c
Autor:
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, John A. Rathmacher, Keith T. Wilson
Publikováno v:
Oncogene. 42:1685-1691