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Autor:
Gérard Le Fur, Michele Arnone, Philippe Soubrie, Christian Congy, Didier Oustric, Olivier Finance, Murielle Rinaldi-Carmona, Jeanne Maruani, Francis Barth, Martine Poncelet, Serge Martinez, Alain Pério
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 310(3)
Based on binding, functional, and pharmacological data, this study introduces SR147778 [5-(4-bromophenyl)-1-(2,4-dichloro-phenyl)-4-ethyl- N -(1-piperidinyl)-1 H -pyrazole-3-carboxamide] as a highly potent, selective, and orally active antagonist for