Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Alain Nepveu"'
Autor:
Mai Aly, Zubaidah M. Ramdzan, Yasunobu Nagata, Suresh K. Balasubramanian, Naoko Hosono, Hideki Makishima, Valeria Visconte, Teodora Kuzmanovic, Vera Adema, Aziz Nazha, Bartlomiej P. Przychodzen, Cassandra M. Kerr, Mikkael A. Sekeres, Mohamed E. Abazeed, Alain Nepveu, Jaroslaw P. Maciejewski
Publikováno v:
Blood Advances, Vol 3, Iss 14, Pp 2164-2178 (2019)
Abstract: Somatic mutations of the CUT-like homeobox 1 (CUX1) gene (CUX1MT) can be found in myeloid neoplasms (MNs), in particular, in myelodysplastic syndromes (MDSs). The CUX1 locus is also deleted in 3 of 4 MN cases with −7/del(7q). A cohort of
Externí odkaz:
https://doaj.org/article/7f6d88bec9344a2eb21aa0b0bbb7c48b
Autor:
Dindial Ramotar, Alain Nepveu
Publikováno v:
Journal of Radiation and Cancer Research, Vol 9, Iss 2, Pp 67-78 (2018)
Many endogenous and exogenous sources produce reactive oxygen species such as superoxide radical anions and hydrogen peroxide that are converted to the highly reactive form, hydroxyl radical. It is this latter species that can damage several macromol
Externí odkaz:
https://doaj.org/article/d20ec2e007bd4d6c80c2969e12359c0f
Autor:
Ajinkya Revandkar, Maria Luna Perciato, Alberto Toso, Abdullah Alajati, Jingjing Chen, Hermeto Gerber, Mitko Dimitrov, Andrea Rinaldi, Nicolas Delaleu, Emiliano Pasquini, Rocco D’Antuono, Sandra Pinton, Marco Losa, Letizia Gnetti, Alberto Arribas, Patrick Fraering, Francesco Bertoni, Alain Nepveu, Andrea Alimonti
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Notch signalling is involved in prostate cancer progression and therapeutic resistance. Here, the authors show that loss of PTEN in prostate cancer models results in increased Notch1 cleavage and activation through CUX1-mediated transactivation of AD
Externí odkaz:
https://doaj.org/article/ea3cbc2df78f4176a7c391021d800478
Autor:
Charles Vadnais, Peiman Shooshtarizadeh, Charles V. Rajadurai, Robert Lesurf, Laura Hulea, Sayeh Davoudi, Chantal Cadieux, Michael Hallett, Morag Park, Alain Nepveu
Publikováno v:
Biology Open, Vol 3, Iss 10, Pp 937-946 (2014)
Autocrine activation of the Wnt/β-catenin pathway occurs in several cancers, notably in breast tumors, and is associated with higher expression of various Wnt ligands. Using various inhibitors of the FZD/LRP receptor complex, we demonstrate that som
Externí odkaz:
https://doaj.org/article/8adcf04b7a784605afc7941617448796
Autor:
Zubaidah M Ramdzan, Charles Vadnais, Ranjana Pal, Guillaume Vandal, Chantal Cadieux, Lam Leduy, Sayeh Davoudi, Laura Hulea, Lu Yao, Anthony N Karnezis, Marilène Paquet, David Dankort, Alain Nepveu
Publikováno v:
PLoS Biology, Vol 12, Iss 3, p e1001807 (2014)
The Cut homeobox 1 (CUX1) gene is a target of loss-of-heterozygosity in many cancers, yet elevated CUX1 expression is frequently observed and is associated with shorter disease-free survival. The dual role of CUX1 in cancer is illustrated by the fact
Externí odkaz:
https://doaj.org/article/547186a6161b417bae65cf422358505f
Autor:
Alain Nepveu, Barry J. Bedell, Christian Bédard, Alan C. Peterson, Sylvie Fournier, Chantal Cadieux
Supplementary Tables 3-6, Figure 5 from Transgenic Mice Expressing the p75 CCAAT-Displacement Protein/Cut Homeobox Isoform Develop a Myeloproliferative Disease–Like Myeloid Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a269a7731a09c439ed79aebe1a46c3f6
https://doi.org/10.1158/0008-5472.22364726
https://doi.org/10.1158/0008-5472.22364726
Autor:
Alain Nepveu, Barry J. Bedell, Christian Bédard, Alan C. Peterson, Sylvie Fournier, Chantal Cadieux
The p75 CCAAT-displacement protein/Cut homeobox (CDP/Cux) isoform was previously reported to be overexpressed in human breast cancers. To investigate its oncogenic potential, we engineered two transgenic mouse lines expressing p75 CDP/Cux under the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cda5ecedca3200094d8fd063b68ce53
https://doi.org/10.1158/0008-5472.c.6494330
https://doi.org/10.1158/0008-5472.c.6494330
Autor:
Alain Nepveu, Marilène Paquet, Maria Drossos, Charles Vadnais, Lu Yao, Valérie Kedinger, Chantal Cadieux
Supplementary Tables 1-2, Figure 1 from Mouse Mammary Tumor Virus p75 and p110 CUX1 Transgenic Mice Develop Mammary Tumors of Various Histologic Types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54852e6e14d699659d735fb85460fb1f
https://doi.org/10.1158/0008-5472.22379270.v1
https://doi.org/10.1158/0008-5472.22379270.v1
Autor:
Alain Nepveu, Marilène Paquet, Maria Drossos, Charles Vadnais, Lu Yao, Valérie Kedinger, Chantal Cadieux
The p75 and p110 isoforms of the CUX1 homeodomain protein are overexpressed in breast tumors and cancer cell lines. To assess and compare the ability of these short CUX1 isoforms in driving mammary tumor development, we used site-specific transgenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1dccd81947bc753ca703f6573e3f91
https://doi.org/10.1158/0008-5472.c.6499199.v1
https://doi.org/10.1158/0008-5472.c.6499199.v1
Publikováno v:
Cancer Drug Resistance. 5:703-20
Cancer cells, in which the RAS and PI3K pathways are activated, produce high levels of reactive oxygen species (ROS), which cause oxidative DNA damage and ultimately cellular senescence. This process has been documented in tissue culture, mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a195b7d1c737b278109d331b66fa8a
https://doi.org/10.20517/cdr.2022.36
https://doi.org/10.20517/cdr.2022.36