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Akademický článek

Sodium is a negative allosteric regulator of the ghrelin receptor

Autor: Guillaume Ferré, Antoniel A.S. Gomes, Maxime Louet, Marjorie Damian, Paulo M. Bisch, Olivier Saurel, Nicolas Floquet, Alain Milon, Jean-Louis Banères

Publikováno v: Cell Reports, Vol 42, Iss 4, Pp 112320- (2023)

Summary: The functional properties of G protein-coupled receptors (GPCRs) are intimately associated with the different components in their cellular environment. Among them, sodium ions have been proposed to play a substantial role as endogenous allos

Externí odkaz: https://doaj.org/article/87d8f738adc04c9e83cc8a315be00c42

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Akademický článek

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Publikováno v: EMBO Molecular Medicine, Vol 6, Iss 10, Pp 1328-1346 (2014)

Abstract Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand‐binding domain bound to 17β‐estradiol (E2) and E4 are

Externí odkaz: https://doaj.org/article/f81d485b302d454596333e69beb5f6bc

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Akademický článek

Virtual and biophysical screening targeting the γ-tubulin complex--a new target for the inhibition of microtubule nucleation.

Autor: Olivier Cala, Marie-Hélène Remy, Valérie Guillet, Andreas Merdes, Lionel Mourey, Alain Milon, Georges Czaplicki

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63908 (2013)

Microtubules are the main constituents of mitotic spindles. They are nucleated in large amounts during spindle assembly, from multiprotein complexes containing γ-tubulin and associated γ-tubulin complex proteins (GCPs). With the aim of developing a

Externí odkaz: https://doaj.org/article/75705f809df6439785004efd0ffb3743

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À qui s’adresse la mise en accusation de Baudelaire ?

Autor: Alain Milon

Publikováno v: Romanic Review. 113:407-422

Résumé Baudelaire en accusation : au premier abord, cette formule semble porter sur la manière dont Baudelaire a été censuré ainsi que sur les conséquences d’une telle censure sur son activité d’écrivain. Baudelaire en accusation voudrai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::216818e3ccfdccabf33278a21f3408f1
https://doi.org/10.1215/00358118-10055121

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Déférence métropolitaine

Autor: Alain Milon

Publikováno v: Multitudes. :190-196

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6391da959d741f90a04250a5d84a33b
https://doi.org/10.3917/mult.083.0190

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Au croisement de la poésie et de la philosophie : Francis Ponge et Maurice Merleau-Ponty

Autor: Alain Milon, I-Ning Yang

Publikováno v: Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, Vol 22, Iss 1 (2020)

At the crossroads of poetry and philosophy: Francis Ponge and Maurice Merleau-Ponty The aim of the present article is to clarify the place of the sensitive dictionary in the work of Francis Ponge and to show how it denotes human's relationship to nat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ab969a96110bf8498b46ea143e2bee
https://doi.org/10.25180/lj.v22i1.232

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The conical shape of DIM lipids promotes Mycobacterium tuberculosis infection of macrophages

Autor: Franck Jolibois, Christophe Guilhot, Matthieu Chavent, Catherine Astarie-Dequeker, Alain Milon, Evert Haanappel, Nicolas Destainville, Georges Czaplicki, Jacques Augenstreich, Guillaume Ferré

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2019
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019
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Phthiocerol dimycocerosate (DIM) is a major virulence factor of the pathogen Mycobacterium tuberculosis ( Mtb ). While this lipid promotes the entry of Mtb into macrophages, which occurs via phagocytosis, its molecular mechanism of action is unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb2a2b15359fde62942783f34d8d236
https://doi.org/10.1073/pnas.1910368116

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Identification of new lead molecules against anticancer drug target TFIIH subunit P8 using biophysical and molecular docking studies

Autor: Pascal Ramos, Virginie Gervais, Sumaira Javaid, Atta-ur-Rahman, Alain Milon, Atia-tul-Wahab, M. Iqbal Choudhary, Isabelle Muller, Humaira Zafar

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2021, 114, pp.105021. ⟨10.1016/j.bioorg.2021.105021⟩

The identification of molecules, which could modulate protein-protein interactions (PPIs), is of primary interest to medicinal chemists. Using biophysical methods during the current study, we have screened 76 compounds (grouped into 16 mixtures) agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2107a67d8911ec96012514b5772a85a6
https://pubmed.ncbi.nlm.nih.gov/34120023

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