Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alain Merkli"'
Autor:
Klaus Brandenburg, Alain Merkli, J. Gwynfor Davies, Andra B. Schromm, Claude Zbaeren, Ulrich Seydel, Buko Lindner, Jacques Bauer, Michel H. J. Koch
Publikováno v:
European Journal of Biochemistry. 267:3370-3377
The triacylated lipid A partial structure OM-174 was characterized in detail using a variety of physical and biological techniques. OM-174 aggregates adopt the micellar HI structure. The temperature (Tc) of the gel to liquid-crystalline phase transit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6de8212fd126aa71b8fd0b93c7946e7c
https://doi.org/10.1046/j.1432-1327.2000.01370.x
https://doi.org/10.1046/j.1432-1327.2000.01370.x
Publikováno v:
Progress in Polymer Science. 23:563-580
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::388909bbbedee3c2d886b30140bee7a0
https://doi.org/10.1016/s0079-6700(97)00048-8
https://doi.org/10.1016/s0079-6700(97)00048-8
Autor:
J. Heller, S. F. Bernatchez, Monia Zignani, Alain Merkli, Robert Gurny, Martina Barbara Sintzel, Werner Kloeti, Cyrus Tabatabay
Publikováno v:
Journal of Controlled Release. 48:115-129
After a brief historical overview of the development of three families of poly(ortho esters) (POEs), the physico-chemical characteristics, drug release properties and biocompatibility of the third generation is discussed. Its synthesis is based on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::519a62128bc5c98d4e5fcc4488db0a6e
https://doi.org/10.1016/s0168-3659(97)00050-3
https://doi.org/10.1016/s0168-3659(97)00050-3
Publikováno v:
Drug Development and Industrial Pharmacy, Vol. 23, No 9 (1997) pp. 857-878
A survey was made of the influence of irradiation sterilization on relevant natural, semisynthetic, and synthetic polymers used for drug carrier system. The first part of the review deals with some general aspects of irradiation treatment and its use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c981e1d272d18f28cf1d4d273805c49
https://doi.org/10.3109/03639049709148693
https://doi.org/10.3109/03639049709148693
Publikováno v:
Journal of Controlled Release. 33:415-421
Semi-solid poly(ortho esters) (POE) prepared by a transesterification reaction between trimethyl orthoacetate and 1,2,6-hexanetriol were investigated as injectable bioerodible polymers for the controlled release of 5-fluorouracil (5-FU) and mitomycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9276b7fbe379069924c7e717098fca85
https://doi.org/10.1016/0168-3659(94)00117-d
https://doi.org/10.1016/0168-3659(94)00117-d
Publikováno v:
Journal of Controlled Release. 29:105-112
A semi-solid poly(ortho ester) was prepared by the reaction between 1,2,6-hexanetriol and trimethyl orthoacetate. The use of a flexible triol such as 1,2,6-hexanetriol produces highly flexible polymers that have viscous behavior at room temperature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::900e99ea5e672aaf48d15c7f50be1056
https://doi.org/10.1016/0168-3659(94)90126-0
https://doi.org/10.1016/0168-3659(94)90126-0
Biotolerance of a semisolid hydrophobic biodegradable poly(ortho ester) for controlled drug delivery
Autor:
Cyrus Tabatabay, Qinghong H. Zhao, Jorge Heller, Robert Gurny, S. F. Bernatchez, James M. Anderson, Alain Merkli
Publikováno v:
Journal of Biomedical Materials Research. 27:677-681
We evaluated the biotolerance of a new semisolid poly(ortho ester) (POE) intended for controlled drug delivery. Two different investigations were carried out in rats: subcutaneous injections and the cage-implant system. Sodium hyaluronate (SH), 1%, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bc72777e2495825aba7c3f9ee44ea3
https://doi.org/10.1002/jbm.820270515
https://doi.org/10.1002/jbm.820270515
Publikováno v:
Journal of Biomaterials Science, Polymer Edition. 4:505-516
Since the late 1970s, three families of poly(ortho esters) (POE) were synthesized to provide bioerodible carriers for drug delivery devices. The most recent POE is a semi-solid polymer with a viscous behavior at room temperature. Polymer synthesis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3334293503f6b7087b74eb6435b94e97
https://doi.org/10.1163/156856293x00168
https://doi.org/10.1163/156856293x00168
Publikováno v:
International Journal of Pharmaceutics, Vol. 155, No 2 (1997) pp. 263-269
Viscous poly(ortho-ester)s (POE), synthesised by a transesterification reaction between a substituted orthoacetate and a triol have been shown to be bioerodible polymers and are currently under investigation as a drug carrier material. Main efforts o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145c38c1f16698f0d5f1d25cb4901ee7
https://archive-ouverte.unige.ch/unige:85277
https://archive-ouverte.unige.ch/unige:85277
Publikováno v:
Biomaterials, Vol. 17, No 9 (1996) pp. 897-902
The research work carried out for developing bioerodible drug delivery devices in which the erosion process was to be confined to the polymer-water interface is at the origin of the discovery of a class of polymers known as poly(ortho esters) (POEs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f7b82926b314f50ea2fcd9f5f49c0c
https://archive-ouverte.unige.ch/unige:81645
https://archive-ouverte.unige.ch/unige:81645