Recognition forces involved in mitochondrial binding to a low-affinity trimetazidine binding site related to anti-ischemic activity

Autor: Alain Le Ridant, Jean Paul Tillement, Georgette Plemper van Balen, Bernard Testa, Didier Morin, Pierre-Alain Carrupt

Publikováno v: Biochemical Pharmacology, Vol. 63, No 9 (2002) pp. 1691-1697

A number of heterogeneous drugs previously shown to bind to trimetazidine (TMZ) binding sites on mitochondria and to inhibit mitochondrial swelling (Morin et al., Br J Pharmacol 1998;123:1385-94) were investigated here for their physicochemical prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02c00775e9ddadc9b1731fa187bf2f6
https://doi.org/10.1016/s0006-2952(02)00913-9

The neuroprotective activity of 8-alkylamino-1,4-benzoxazine antioxidants

Autor: Alain Le Ridant, Martine Largeron, Michael Spedding, Bettina Mesples, Roméo Cecchelli, Pierre Gressens, Maurice-Bernard Fleury

Publikováno v: European Journal of Pharmacology
European Journal of Pharmacology, Elsevier, 2001, 424 (3), pp.189-194. ⟨10.1016/S0014-2999(01)01152-9⟩
European Journal of Pharmacology, Elsevier, 2001, 424, p. 189-194

International audience; Antioxidant 8-alkylamino-1,4-benzoxazines, (R,S)-(3-tert-butyl-8-phenylethylamino-3,4-dihydro-2H-1,4-benzoxazin-5-yl) (phenyl) methanone (S 24429) and (R,S)-(3-cyclopentyl-8-benzylamino-3,4-dihydro-2H-1,4-benzoxazin-5-yl) (phe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b27d0b9bf7525d9998c65321af80529
https://hal.archives-ouvertes.fr/hal-02385117