Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Alain Le Pape"'
Autor:
Daniel Göhler, Antje Geldner, Ralf Gritzki, Franz Lohse, Stephan Große, Julien Sobilo, Clemens Felsmann, Jonathan R. Buggisch, Alain Le Pape, Andreas Rudolph, Michael Stintz, Urs Giger-Pabst
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were dev
Externí odkaz:
https://doaj.org/article/b1a0f240eea44bb2911eaa2667ca4356
Autor:
Phuoc-Vinh Nguyen, Emilie Allard-Vannier, Nicolas Aubrey, Christine Labrugère-Sarroste, Igor Chourpa, Julien Sobilo, Alain Le Pape, Katel Hervé-Aubert
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2679 (2022)
Following our previous study on the development of EGFR-targeted nanomedicine (NM-scFv) for the active delivery of siRNA in EGFR-positive cancers, this study focuses on the development and the quality control of a radiolabeling method to track it in
Externí odkaz:
https://doaj.org/article/215c435d3c9546a094882bb4ee984efd
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Aerosol sizing is generally measured at ambient air but human airways have different temperature (37°C) and relative humidity (100%) which can affect particle size in airways and consequently deposition prediction. This work aimed to develop and eva
Externí odkaz:
https://doaj.org/article/c947fbd248804ad7a254b6cd7ae15b56
Autor:
Chloé J Arthuis, Anthony Novell, Florian Raes, Jean-Michel Escoffre, Stéphanie Lerondel, Alain Le Pape, Ayache Bouakaz, Franck Perrotin
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169850 (2017)
PURPOSE:This preclinical study aimed to evaluate placental oxygenation in pregnant rats by real-time photoacoustic (PA) imaging on different days of gestation and to specify variations in placental oxygen saturation under conditions of maternal hypox
Externí odkaz:
https://doaj.org/article/cf010694b805466a83a17c4fdab76f1e
Autor:
Florian Raes, Julien Sobilo, Marilyne Le Mée, Stéphanie Rétif, Sharuja Natkunarajah, Stéphanie Lerondel, Alain Le Pape
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153532 (2016)
OBJECTIVES:We have developed a relevant preclinical model associated with a specific imaging protocol dedicated to onco-pharmacology studies in mice. MATERIALS AND METHODS:We optimized both the animal model and an ultrasound imaging procedure to foll
Externí odkaz:
https://doaj.org/article/467dbb77e978419e986eee56b747081a
Autor:
Nader Al Nakouzi, Olivia Bawa, Alain Le Pape, Stéphanie Lerondel, Catherine Gaudin, Paule Opolon, Patrick Gonin, Karim Fizazi, Anne Chauchereau
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 5, Pp 376-387 (2012)
Bone metastases have a devastating impact on quality of life and bone pain in patients with prostate cancer and decrease survival. Animal models are important tools in investigating the pathogenesis of the disease and in developing treatment strategi
Externí odkaz:
https://doaj.org/article/b01ee839269e4a79a3ad93f08799154e
Autor:
Sabrina Pesnel, Arnaud Pillon, Laurent Créancier, Stéphanie Lerondel, Alain Le Pape, Christian Recher, Cécile Demur, Nicolas Guilbaud, Anna Kruczynski
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30690 (2012)
BACKGROUND: The assessment of anticancer agents to treat leukemia needs to have animal models closer to the human pathology such as implantation in immunodeficient mice of leukemic cells from patient samples. A sensitive and early detection of tumor
Externí odkaz:
https://doaj.org/article/8c88429517e84eb296d1f31dfea5fdfe
Autor:
Laura Brullé, Marc Vandamme, Delphine Riès, Eric Martel, Eric Robert, Stéphanie Lerondel, Valérie Trichet, Serge Richard, Jean-Michel Pouvesle, Alain Le Pape
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52653 (2012)
Pancreatic tumors are the gastrointestinal cancer with the worst prognosis in humans and with a survival rate of 5% at 5 years. Nowadays, no chemotherapy has demonstrated efficacy in terms of survival for this cancer. Previous study focused on the de
Externí odkaz:
https://doaj.org/article/e03da5e35e26440493009f4318217cdf
Autor:
Sabrina Pesnel, Smaïl Akkoul, Roger Ledée, Rémy Leconge, Arnaud Pillon, Anna Kruczynski, Rachid Harba, Stéphanie Lerondel, Alain Le Pape
Publikováno v:
Molecular Imaging, Vol 10 (2011)
To improve spatial resolution in in vivo bioluminescence imaging, a photon scattering correction, image restoration method was tested. The chosen algorithm was tested on in vivo bioluminescent images acquired on three representative tumor models: sub
Externí odkaz:
https://doaj.org/article/f99433b0e39845e19ab6ea41df0748ba
Autor:
Rémi Châtre, Estelle Blochouse, Rony Eid, Fabiola Djago, Justin Lange, Mehrad Tarighi, Brigitte Renoux, Julien Sobilo, Alain Le Pape, Jonathan Clarhaut, Claude Geffroy, Isabelle Opalinski, Wei Tuo, Sébastien Papot, Pauline Poinot
Publikováno v:
Chemical Science. 14:4697-4703
We developed a volatile organic compound (VOC)-based probe cocktail for monitoring the dysregulation of tumour-associated enzymes via the detection of volatile tracers in animal breath, thereby allowing the discovery of a new tumour targeted therapy.