Výsledky vyhledávání - "Alain Laigle"

Modulation of MDR1 gene expression in multidrug resistant MCF7 cells by low concentrations of small interfering RNAs

Autor: Vérène Stierlé, Alain Laigle, Béatrice Jolles

Publikováno v: Biochemical Pharmacology. 70:1424-1430

MDR1 overexpression is one form of the multidrug resistance (MDR) phenotype, which can be acquired by patients initially responsive to chemotherapy. Because of the high toxicity of the inhibitors of P-glycoprotein (P-gp), the protein encoded by MDR1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa3206db283fc9a124eadad9298b9f6
https://doi.org/10.1016/j.bcp.2005.08.007

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The Reduction of P-Glycoprotein Expression by Small Interfering RNAs Is Improved in Exponentially Growing Cells

Autor: Vérène Stierlé, Alain Laigle, Béatrice Jollès

Publikováno v: Oligonucleotides. 14:191-198

Small interfering RNAs (siRNAs) are powerful tools in specifically silencing gene expression. Nevertheless, their efficiency can be limited when targeting proteins with an unusually long half-life, such as P-glycoprotein (P-gp), which is involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f0bc42cef399f117e58eee14c71390
https://doi.org/10.1089/oli.2004.14.191

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Best Minimally Modified Antisense Oligonucleotides According to Cell Nuclease Activity

Autor: Alain Laigle, Taraneh Djavanbakht Samani, Béatrice Jollès

Publikováno v: Antisense and Nucleic Acid Drug Development. 11:129-136

Minimally modified oligonucleotides belong to the second-generation antisense class. They are phosphodiester oligonucleotides with a minimum of phosphorothioate linkages in order to be protected against serum and cellular exonucleases and endonucleas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077122b916d5788a7ab75cfdf4397bbe
https://doi.org/10.1089/108729001300338654

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Resonance Raman analysis of a fluorescently labeled oligonucleotide forming a very stable hairpin

Autor: Alain Laigle, Matthieu Réfrégiers, Laurent Chinsky, Béatrice Jollès, Gavin V. Wheeler

Publikováno v: European Biophysics Journal. 26:277-281

An oligodeoxynucleotide has been synthesized, which mimics an ``antigene'' oligonucleotide with a polypyrimidic stretch on its 5′ side and is protected on its 3′ side against nucelases by a naturally forming and very stable hairpin, 5′GCGAAGC3�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dd36177c473427eac01341999ee0970
https://doi.org/10.1007/s002490050081

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A UV Resonant Raman Spectroscopic Study of the Interaction of Metallic Derivatives of Tetrakis(4-N-methylpyridyl)porphine with Polynucleotides

Autor: Gavin V. Wheeler, Alain Laigle, L. Chinsky

Publikováno v: Journal of Biomolecular Structure and Dynamics. 15:107-117

Resonance Raman spectra excited at 257 nm are reported for the complexes of the Nickel, Cobalt and Zinc derivatives of Tetrakis(4-N-methylpyridyl)porphine with poly(dA.dT)2, poly(dA)poly(dT), poly(dG.dC)2 and poly(dG).poly(dC). These spectra are inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5bb54f9eb799c7ed7fb40f1669be28
https://doi.org/10.1080/07391102.1997.10508950

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The Overall Partitioning of Anthracyclines into Phosphatidyl-Containing Model Membranes Depends Neither on the Drug Charge Nor the Presence of Anionic Phospholipids

Autor: Laurence Gallois, Arlette Garnier-Suillerot, Alain Laigle, Marina M.-L. Fiallo, Waldemar Priebe

Publikováno v: European Journal of Biochemistry. 241:879-887

Anthracyclines are potent anticancer agents. Their use is limited by the problem of multidrug resistance (MDR) associated with a decreased intracellular accumulation of drug correlated with the presence, in the membrane of resistant cells, of the P-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5556a82d005779205a0bf30383e6a5c
https://doi.org/10.1111/j.1432-1033.1996.00879.x

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Spectral shape modifications of anthracyclines bound to cell nuclei: a microspectrofluorometric study

Autor: Alain Laigle, Ariette Garnier-Suillerot, Marina M.-L. Fiallo

Publikováno v: Chemico-Biological Interactions. 101:49-58

Anthracyclines remain today the medications of choice against a wide spectrum of human cancers. Anthracyclines are fluorescent molecules and microfluorimetric methods are often used to determine their cellular distribution. The use of microspectroflu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb85172385c7c9559f218ccf7c7529f
https://doi.org/10.1016/0009-2797(96)03710-6

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Targeting MDR1 gene: synthesis and cellular study of modified daunomycin-triplex-forming oligonucleotide conjugates able to inhibit gene expression in resistant cell lines

Autor: Vérène Stierlé, Maria Duca, Ludovic Halby, Catherine Senamaud-Beaufort, Massimo L. Capobianco, Paola B. Arimondo, Béatrice Jollès, Alain Laigle

Publikováno v: Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2008, 73 (5), pp.1568-1577
Molecular pharmacology
73 (2008): 1568–1577. doi:10.1124/mol.107.042010
info:cnr-pdr/source/autori:Stierle, Verene (1); Duca, Maria (2); Halby, Ludovic (2); Senamaud-Beaufort, Catherine (2); Capobianco, Massimo L. (3); Laigle, Alain (1); Jolles, Beatrice (1); Arimondo, Paola B./titolo:Targeting MDR1 gene: Synthesis and cellular study of modified daunomycin-triplex-forming oligonucleotide conjugates able to inhibit gene expression in resistant cell lines/doi:10.1124%2Fmol.107.042010/rivista:Molecular pharmacology (Print)/anno:2008/pagina_da:1568/pagina_a:1577/intervallo_pagine:1568–1577/volume:73

Reversal of the multidrug-resistant (MDR) phenotype is very important for chemotherapy success. In fact, the expression of the MDR1 gene-encoded P-glycoprotein (P-gp) actively expels antitumor agents such as daunomycin (DNM) out of the cells, resulti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afe2626028cdf85f24a7d412549b5c8
https://hal.archives-ouvertes.fr/hal-00449265

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An Ultraviolet Micro-Raman Spectrometer: Resonance Raman Spectroscopy within Single Living Cells

Autor: Pierre-Yves Turpin, Jean-Pierre Ballini, P. Vigny, Alain Laigle, C. Amirand, L. Chinsky, M. Duquesne, Franck Sureau

Publikováno v: Applied Spectroscopy. 44:1047-1051

Ultraviolet-excited resonance Raman spectra have been obtained for the first time for microsamples of dAMP deoxymononucleotide and DNA and for the nuclear DNA of a single living T47D cultured cell. The spectral variations observed in changing the exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7f1eb7b58e29ba4b745b945fd6b9320
https://doi.org/10.1366/0003702904086920

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A PORPHYRIN-DNA EXCIPLEX: RESONANCE RAMAN SPECTRA OF ELECTRONICALLY EXCITED Cu(TMpy-P4) BOUND TO POLY(dA-dT)-POLY(dA-dT)

Autor: Pierre-Yves Turpin, Alain Laigle, M. Tsuboi, L. Chinsky, Kazuo Nakamoto, J. R. Kincaid

Publikováno v: Photochemistry and Photobiology. 51:519-525

The resonance Raman spectra of water-soluble porphyrins, Cu(TMpy-P4) and Ni(TMpy-P4), and their mixtures with DNA, Poly(dG-dC).Poly(dG-dC), and Poly(dA-dT).Poly(dA-dT) were measured using 426 nm pulsed laser excitation (and 556 nm for some applicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0821ef41ef3344d785eea6edee6a0c07
https://doi.org/10.1111/j.1751-1097.1990.tb01960.x

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