Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Alain Ktorza"'
Autor:
Céline Cruciani-Guglielmacci, Lara Bellini, Jessica Denom, Masaya Oshima, Neïké Fernandez, Priscilla Normandie-Levi, Xavier P. Berney, Nadim Kassis, Claude Rouch, Julien Dairou, Tracy Gorman, David M. Smith, Anna Marley, Robin Liechti, Dmitry Kuznetsov, Leonore Wigger, Frédéric Burdet, Anne-Laure Lefèvre, Isabelle Wehrle, Ingo Uphues, Tobias Hildebrandt, Werner Rust, Catherine Bernard, Alain Ktorza, Guy A. Rutter, Raphael Scharfmann, Ioannis Xenarios, Hervé Le Stunff, Bernard Thorens, Christophe Magnan, Mark Ibberson
Publikováno v:
Molecular Metabolism, Vol 6, Iss 4, Pp 340-351 (2017)
Objective: In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes involved in pancreatic beta cell dysfunction by analyzing
Externí odkaz:
https://doaj.org/article/64a96d3c764e447db5466d3eb59128b0
Autor:
Leonore Wigger, Céline Cruciani-Guglielmacci, Anthony Nicolas, Jessica Denom, Neïké Fernandez, Frédéric Fumeron, Pedro Marques-Vidal, Alain Ktorza, Werner Kramer, Anke Schulte, Hervé Le Stunff, Robin Liechti, Ioannis Xenarios, Peter Vollenweider, Gérard Waeber, Ingo Uphues, Ronan Roussel, Christophe Magnan, Mark Ibberson, Bernard Thorens
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2269-2279 (2017)
Summary: Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma lipid species whose concentrations correlate with
Externí odkaz:
https://doaj.org/article/865e313113de4b74a761a02e351ed9e5
Autor:
Stéphanie Lucas, Solenne Taront, Christophe Magnan, Laurence Fauconnier, Myriam Delacre, Laurence Macia, Anne Delanoye, Claudie Verwaerde, Corentin Spriet, Pasquine Saule, Gautier Goormachtigh, Laurent Héliot, Alain Ktorza, Jamileh Movassat, Renata Polakowska, Claude Auriault, Odile Poulain-Godefroy, James Di Santo, Philippe Froguel, Isabelle Wolowczuk
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40351 (2012)
Although interleukin (IL)-7 is mostly known as a key regulator of lymphocyte homeostasis, we recently demonstrated that it also contributes to body weight regulation through a hypothalamic control. Previous studies have shown that IL-7 is produced by
Externí odkaz:
https://doaj.org/article/34849937db524eed90a4971123e86e33
Autor:
Sabrina Le Bouter, Marianne Rodriguez, Nolwen Guigal-Stephan, Sophie Courtade-Gaïani, Laura Xuereb, Catherine de Montrion, Vincent Croixmarie, Thierry Umbdenstock, Claire Boursier-Neyret, Michel Lonchampt, Manuel Brun, Catherine Dacquet, Alain Ktorza, Brian-Paul Lockhart, Jean-Pierre Galizzi
Publikováno v:
PPAR Research, Vol 2010 (2010)
Rosiglitazone (RSG), developed for the treatment of type 2 diabetes mellitus, is known to have potent effects on carbohydrate and lipid metabolism leading to the improvement of insulin sensitivity in target tissues. To further assess the capacity of
Externí odkaz:
https://doaj.org/article/46df16f6182e4c53869defeac3035f9f
Autor:
Melis Karaca, Julien Castel, Cécile Tourrel-Cuzin, Manuel Brun, Anne Géant, Mathilde Dubois, Sandra Catesson, Marianne Rodriguez, Serge Luquet, Pierre Cattan, Brian Lockhart, Jochen Lang, Alain Ktorza, Christophe Magnan, Catherine Kargar
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5555 (2009)
BACKGROUND:The mass of pancreatic beta-cells varies according to increases in insulin demand. It is hypothesized that functionally heterogeneous beta-cell subpopulations take part in this process. Here we characterized two functionally distinct group
Externí odkaz:
https://doaj.org/article/8724d91fecfc43fcb0213d5b4b406d2b
Autor:
Robert H Wallis, Stephan C Collins, Pamela J Kaisaki, Karène Argoud, Steven P Wilder, Karin J Wallace, Massimiliano Ria, Alain Ktorza, Patrik Rorsman, Marie-Thérèse Bihoreau, Dominique Gauguier
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2962 (2008)
BACKGROUND:Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS:We have generated extensive physiological, genetic and g
Externí odkaz:
https://doaj.org/article/1872e1fd71ef4dab85caf745480c854a
Autor:
Pascal Ferré, Alain Ktorza
Publikováno v:
Perinatal Biochemistry ISBN: 9781003068624
Perinatal Biochemistry
Perinatal Biochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34720e2bbdee8fec1b3ece4626e697bf
https://doi.org/10.4324/9781003068624-7
https://doi.org/10.4324/9781003068624-7
Autor:
András Kotschy, Isabelle Theret, Attila Paczal, Frédéric De Ceuninck, Zoltán B. Szabó, Catherine Bernard, Alain Ktorza, Balázs Bálint, Csaba Wéber, Perron-Sierra Françoise, Levente Ondi
Publikováno v:
Journal of Medicinal Chemistry. 59:687-706
7-Azaindole has been identified as a novel bidentate anchor point for allosteric glucokinase activators. A systematic investigation around three principal parts of the new small molecule glucokinase activators led to a robust SAR in agreement with st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b2a87148aee12dcf7786d6b8e541f3
https://doi.org/10.1021/acs.jmedchem.5b01594
https://doi.org/10.1021/acs.jmedchem.5b01594
Autor:
Catherine Bernard, Aurélie Carlier, Anne-Françoise Batto, Fabienne Foufelle, Olivier Bourron, Nicolas Venteclef, Anaïs Szpigel, Isabelle Hainault, Pascal Ferré, Eric Hajduch, Alain Ktorza, Jean-François Gautier
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2018, 61 (2), pp.399-412. ⟨10.1007/s00125-017-4462-5⟩
Diabetologia, Springer Verlag, 2018, 61 (2), pp.399-412. ⟨10.1007/s00125-017-4462-5⟩
Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4700a3d28472f0e1d138e0ef6ad23d
https://hal.archives-ouvertes.fr/hal-02450833
https://hal.archives-ouvertes.fr/hal-02450833
Autor:
Nathalie Hennuyer, Ghislaine Zanirato, Anne Géant, Catherine Dacquet, Daniel-Henri Caignard, Nicolas Lebegue, Bart Staels, Veronique Leclerc, Celine Pirat, Monique Beucher-Gaudin, Pascal Berthelot, Amaury Farce, Alain Ktorza
Publikováno v:
European journal of medicinal chemistry. 137
A series of benzothiazol-2-one containing α-ethoxyphenylpropionic acid derivatives incorporating resveratrol or butein scaffolds were designed as fused full PPARγ agonist ligands and SIRT1-activating compounds for the treatment of type 2 diabetes (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b194faeb144ae1043352a41573633
https://pubmed.ncbi.nlm.nih.gov/28609708
https://pubmed.ncbi.nlm.nih.gov/28609708