Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alain Jeanrenaud"'
Autor:
Mara De Marco Zompit, Mònica Torres Esteban, Clémence Mooser, Salomé Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, Ann-Marie K. Shorrocks, Andrew N. Blackford, Daniel Durocher, Manuel Stucki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei formation and chromosomal instability.
Externí odkaz:
https://doaj.org/article/6bb76f98748d456bb28f51f91a387637
Autor:
Clémence Mooser, Ioanna-Eleni Symeonidou, Pia-Amata Leimbacher, Alison Ribeiro, Ann-Marie K. Shorrocks, Stephanie Jungmichel, Sara C. Larsen, Katja Knechtle, Arti Jasrotia, Diana Zurbriggen, Alain Jeanrenaud, Colin Leikauf, Daniel Fink, Michael L. Nielsen, Andrew N. Blackford, Manuel Stucki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleol
Externí odkaz:
https://doaj.org/article/1e40f7a690df46ba8c9721ca498fe614
Autor:
Mara, De Marco Zompit, Mònica Torres, Esteban, Clémence, Mooser, Salomé, Adam, Silvia Emma, Rossi, Alain, Jeanrenaud, Pia-Amata, Leimbacher, Daniel, Fink, Ann-Marie K, Shorrocks, Andrew N, Blackford, Daniel, Durocher, Manuel, Stucki
Publikováno v:
Nature communications. 13(1)
The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB repair in favor of a tethering mechanism that stabilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d80e0144914e61bb7229b5cad78c9085
https://pubmed.ncbi.nlm.nih.gov/35842428
https://pubmed.ncbi.nlm.nih.gov/35842428
Autor:
Alain Jeanrenaud, Michael L. Nielsen, Clémence Mooser, Ioanna-Eleni Symeonidou, Colin Leikauf, Katja Knechtle, Arti Jasrotia, Alison Ribeiro, Ann-Marie K. Shorrocks, Diana Zurbriggen, Daniel Fink, Pia-Amata Leimbacher, Andrew N. Blackford, Manuel Stucki, Sara Larsen, Stephanie Jungmichel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Mooser, C, Symeonidou, I-E, Leimbacher, P-A, Ribeiro, A, Shorrocks, A-M K, Jungmichel, S, Larsen, S C, Knechtle, K, Jasrotia, A, Zurbriggen, D, Jeanrenaud, A, Leikauf, C, Fink, D, Nielsen, M L, Blackford, A N & Stucki, M 2020, ' Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation ', Nature Communications, vol. 11, 123 . https://doi.org/10.1038/s41467-019-13981-x
Nature Communications
Mooser, C, Symeonidou, I-E, Leimbacher, P-A, Ribeiro, A, Shorrocks, A-M K, Jungmichel, S, Larsen, S C, Knechtle, K, Jasrotia, A, Zurbriggen, D, Jeanrenaud, A, Leikauf, C, Fink, D, Nielsen, M L, Blackford, A N & Stucki, M 2020, ' Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation ', Nature Communications, vol. 11, 123 . https://doi.org/10.1038/s41467-019-13981-x
Nature Communications
Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleolar architecture, but the signaling events that regulate these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f157e37d2113ae3a5e8ebc159422ae8d
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