Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Alain Jacquier"'
Autor:
Laura Meyer, Baptiste Courtin, Maïté Gomard, Abdelkader Namane, Emmanuelle Permal, Gwenael Badis, Alain Jacquier, Micheline Fromont-Racine
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0293228 (2023)
Translation initiation is a complex and highly regulated process that represents an important mechanism, controlling gene expression. eIF2A was proposed as an alternative initiation factor, however, its role and biological targets remain to be discov
Externí odkaz:
https://doaj.org/article/d6ae11a88d104476b0f3b374692de1dc
Autor:
Laurence Decourty, Antonia Doyen, Christophe Malabat, Emmanuel Frachon, Delphine Rispal, Bertrand Séraphin, Frank Feuerbach, Alain Jacquier, Cosmin Saveanu
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 593-598 (2014)
Nonsense-mediated mRNA decay (NMD) destabilizes eukaryotic transcripts with long 3′ UTRs. To investigate whether other transcript features affect NMD, we generated yeast strains expressing chromosomal-derived mRNAs with 979 different promoter and o
Externí odkaz:
https://doaj.org/article/7e77ba57b9334124ad7b0f22e19c7d82
Autor:
Cosmin Saveanu, Alain Jacquier
Publikováno v:
eLife, Vol 5 (2016)
Establishing a link between the nonsense-mediated decay pathway and a gene associated with programmed cell death could explain why this pathway is essential in most, but not all, eukaryotes.
Externí odkaz:
https://doaj.org/article/2111917ac57947ebb9a30d29a4229010
Publikováno v:
eLife, Vol 4 (2015)
Nonsense-mediated mRNA decay (NMD) is a translation-dependent RNA quality-control pathway targeting transcripts such as messenger RNAs harboring premature stop-codons or short upstream open reading frame (uORFs). Our transcription start sites (TSSs)
Externí odkaz:
https://doaj.org/article/4fc0945da5244f8ab28e8f132e2e88d3
Autor:
Gérald Peyroche, Cosmin Saveanu, Marc Dauplais, Myriam Lazard, François Beuneu, Laurence Decourty, Christophe Malabat, Alain Jacquier, Sylvain Blanquet, Pierre Plateau
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36343 (2012)
Hydrogen selenide is a recurrent metabolite of selenium compounds. However, few experiments studied the direct link between this toxic agent and cell death. To address this question, we first screened a systematic collection of Saccharomyces cerevisi
Externí odkaz:
https://doaj.org/article/e9c6b80a22464d87a2bdee148b2d7bd3
Autor:
Micheline Fromont-Racine, Abdelkader Namane, Elodie Zhang, Antonia Doyen, Estelle Dacheux, Varun Khanna, Bernard Turcotte, Alain Jacquier
SummaryThe Ski2-Ski3-Ski8 (SKI) complex assists the RNA exosome during the 3’-5’ degradation of cytoplasmic transcripts. Previous reports showed that the SKI complex is involved in the 3’-5’ degradation of mRNA, including 3’ untranslated re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16b8567e83356919d9fb06737330c86
https://hal-pasteur.archives-ouvertes.fr/pasteur-03440988
https://hal-pasteur.archives-ouvertes.fr/pasteur-03440988
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2021, pp.8535-8555. ⟨10.1093/nar/gkab680⟩
Nucleic Acids Research, 2021, pp.8535-8555. ⟨10.1093/nar/gkab680⟩
Nucleic Acids Research, Oxford University Press, 2021, pp.8535-8555. ⟨10.1093/nar/gkab680⟩
Nucleic Acids Research, 2021, pp.8535-8555. ⟨10.1093/nar/gkab680⟩
International audience; Abstract Gene deletion and gene expression alteration can lead to growth defects that are amplified or reduced when a second mutation is present in the same cells. We performed 154 genetic interaction mapping (GIM) screens wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cc1f28b2fa7d8627b12aa2fd97168446
https://hal.archives-ouvertes.fr/hal-03320796
https://hal.archives-ouvertes.fr/hal-03320796
Gene deletion and gene expression alteration can lead to growth defects that are amplified or reduced when a second mutation is present in the same cells. We performed 154 genetic interaction mapping (GIM) screens with mutants related with RNA metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f083dbc23c88422be3a655c3ce4c17db
https://doi.org/10.1101/2020.10.04.325191
https://doi.org/10.1101/2020.10.04.325191
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2020, 32 (3), pp.107942. ⟨10.1016/j.celrep.2020.107942⟩
Cell Reports, Elsevier Inc, 2020, 32 (3), pp.107942. ⟨10.1016/j.celrep.2020.107942⟩
SUMMARYA large share of the non-coding transcriptome in yeast is controlled by the Nrd1-Nab3-Sen1 (NNS) complex, which promotes transcription termination of non-coding RNA (ncRNA) genes, and by the nuclear exosome, which limits the steady state level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efbb714b0e88bce2bb0d3039d42a4a7
https://hal.science/hal-02406597
https://hal.science/hal-02406597
Autor:
Quentin Defenouillère, Micheline Fromont-Racine, Abdelkader Namane, Alain Jacquier, John Mouaikel
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (9), pp.1165-1176. ⟨10.1091/mbc.E16-10-0746⟩
Molecular Biology of the Cell, 2017, 28 (9), pp.1165-1176. ⟨10.1091/mbc.E16-10-0746⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2017, 28 (9), pp.1165-1176. ⟨10.1091/mbc.E16-10-0746⟩
Molecular Biology of the Cell, 2017, 28 (9), pp.1165-1176. ⟨10.1091/mbc.E16-10-0746⟩
The RQC complex involved in protein quality control mechanisms also exists as a ribosome-unbound complex during the escort of aberrant peptides to the proteasome. The E3 ubiquitin ligase Tom1 is a newly identified partner of this light version of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb1775dc1110973a7aba71713bc78ca
https://doi.org/10.1091/mbc.e16-10-0746
https://doi.org/10.1091/mbc.e16-10-0746