Transforming growth factor-β1 increases airway wound repair via MMP-2 upregulation: a new pathway for epithelial wound repair?

Autor: David Advenier, Alain Harf, Emmanuèle Lechapt-Zalcman, Stéphane Galiacy, André Coste, Estelle Escudier, Cécile Charrière-Bertrand, Virginie Prulière-Escabasse, Maria-Pia d'Ortho

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2006, 290, pp.L1277-82. ⟨10.1152/ajplung.00149.2005⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2006, 290, pp.L1277-82. ⟨10.1152/ajplung.00149.2005⟩

International audience; In vivo, transforming growth factor (TGF)-beta1 and matrix metalloproteinases (MMPs) present at the site of airway injury are thought to contribute to epithelial wound repair. As TGF-beta1 can modulate MMP expression and MMPs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136f6a4d676f5c7bb2a43c55ab12f3f8
https://doi.org/10.1152/ajplung.00149.2005

Long-term Effects of Different Humidification Systems on Endotracheal Tube Patency

Autor: Alain Harf, Redouane Fodil, Jérôme Pigeot, Samir Jaber, Daniel Isabey, Laurent Brochard, Salvatore Maurizio Maggiore, Bruno Louis

Publikováno v: Anesthesiology. 100:782-788

Background Accumulation of mucous secretions in an endotracheal tube (ETT) increases its resistance, and the amount of deposit may be affected by the quality of humidification and heating of the inspired gas. Methods The authors assessed the impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7573f1c8bf0d39ddddc4961117af2e42
https://doi.org/10.1097/00000542-200404000-00006

Effect of granulocyte colony-stimulating factor on bleomycin-induced acute lung injury and pulmonary fibrosis

Autor: Alain Harf, Sabine Herigault, Laurent Brochard, Christophe Delclaux, Micheline Levame, Benoît Schlemmer, Elie Azoulay

Publikováno v: Critical Care Medicine. 31:1442-1448

OBJECTIVE Potentially fatal pulmonary toxicity is a dreaded complication of bleomycin. Increased use of granulocyte colony-stimulating factor in patients receiving chemotherapy has been paralleled by an increased incidence of bleomycin-induced pulmon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03cf4766a70961d764249d466ba260c
https://doi.org/10.1097/01.ccm.0000050453.28177.33

Effect of the humidification device on the work of breathing during noninvasive ventilation

Autor: Jérôme Pigeot, Alain Harf, Solenne Taillé, Laurent Brochard, Nicolas Deye, Salvatore Maurizio Maggiore, François Lellouche

Publikováno v: Intensive Care Medicine. 28:1582-1589

Objective. Heat and moisture exchangers (HME) increase circuitry deadspace compared to heated humidifiers (HH). This study compared the effect of HH and HME during noninvasive ventilation (NIV) on arterial blood gases and patient's effort assessed by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4396f24830881d2771795b7a39d24966
https://doi.org/10.1007/s00134-002-1518-9

Granulocyte colony-stimulating factor enhances host defenses against bacterial pneumonia following peritonitis in nonneutropenic rats*

Autor: Laurent Brochard, Claude-James Soussy, Christophe Delclaux, Christian Brun-Buisson, Habiba Attalah, Hélène Jouault, Christine Lasclos, Thierry Guillot, Elie Azoulay, Kun Yang, Alain Harf

Publikováno v: Critical Care Medicine. 30:2107-2114

Objective: Polymorphonuclear cell functions frequently are impaired in critically ill patients, and restoration of normal functions could help to prevent nosocomial infections. The aim of this study was to evaluate the effects of pretreatment with gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d35fd2c13d8dd8fd85b2cc119575f41
https://doi.org/10.1097/00003246-200209000-00026