Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alain Grosset"'
Autor:
Etienne Gautier, Fabrice Barbe, Jean-Pierre Bidouard, Stephen E. O'Connor, Alain Grosset, Philip Janiak
Publikováno v:
European Journal of Pharmacology. 474:117-120
We have studied the ability of SL65.0472 (7-fluoro-2-oxo-4-[2-[4-(thieno[3,2-c]pyridin-4-yl)piperazin-1-yl]ethyl]-1,2-dihydroquinoline-1-acetamide), a 5-hydroxytryptamine (5-HT) 5-HT1B/5-HT2A receptor antagonist, to antagonise the vasoconstrictor eff
Autor:
Dominique Caille, Etienne Gautier, Alain Grosset, Pascale Robineau, Jean-Pierre Bidouard, Christophe Drieu La Rochelle, Philip Janiak, Stephen E. O'Connor
Publikováno v:
European Journal of Pharmacology. 414:259-269
In this study, we describe the cardiovascular effects of SL65.0472 (7-fluoro-2-oxo-4-[2-[4-(thieno[3,2-c] pyridin-4-yl) piperazin-l-yl] ethyl]-1, 2-dihydroquinoline-1-acetamide), a novel 5-hydroxytryptamine (5-HT) receptor antagonist developed for th
Autor:
Alain Grosset, Janine Lorrain, Evelyne Favennec, Véronique Briand, Nicole Duval, Christopher Latham, Christian Hoornaert, Gerard Cremer, Stephen E. O'Connor, Philip Janiak
Publikováno v:
British Journal of Pharmacology. 131:1188-1194
The NHE1 isoform of the Na+/H+ exchanger plays an important role in the regulation of intracellular pH and in cardiac cell injury caused by ischaemia and reperfusion. SL 59.1227 is a novel imidazolypiperidine Na+/H+ antiport inhibitor which is struct
Publikováno v:
Fundamental & Clinical Pharmacology. 11:57-62
We compared the antithrombotic properties of low doses of aspirin (0.03, 0.1 mg kg-1 intravenously [iv]) and metoclopramide (0.1, 0.3 mg kg-1 iv) alone or in combination. The animal model chosen for this study involved the generation of cyclic flow v
Autor:
Nicole Duval, Stephen E. O'Connor, Alain Grosset, Christopher N. Berry, C. Lunven, D.P. O'Brien
Publikováno v:
British Journal of Pharmacology. 118:727-733
1. The antithrombotic action of argatroban, a synthetic thrombin inhibitor, was studied in a canine model of coronary cyclic flow having some of the characteristics of acute unstable angina. Heparin was studied as a reference anticoagulant. 2. Locali
Publikováno v:
European Journal of Pharmacology. 234:137-145
SL 84.0418 is a novel pyrrolo-indole derivative with potent and selective α2-adrenoceptor antagonist activity in vitro and anti-hyperglycemic properties in vivo. In the present study we demonstrated that SL 84.0418 and its active (+) enantiomer, SL
Publikováno v:
European Journal of Pharmacology. 229:105-108
Putative 5-HT 4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD 2 of 6.7. Its effects were antagonised in a selective and c
Autor:
Alain Grosset, Paul J. Schaeffer, Laurence Millet, Luciano Manara, Frédérique Dol-Gleizes, Andre Bernat, Jean-Marc Herbert, Jean-François Gallas, Michele Arnone
Publikováno v:
European journal of pharmacology. 529(1-3)
In diabetic patients, impairment of wound healing is a serious problem which represents a significant health burden. The effect of a highly selective beta-3 adrenoceptor agonist, SR58611A, on wound healing was assessed in animal models of type II dia
Autor:
Monique Delahaye, Andre Bernat, Paul J. Schaeffer, Philippe Janiak, Sylvette Lochot, Irène Lechaire, Patrice Ferrari, Jean-Marc Herbert, Alain Grosset, Stephen E. O'Connor, Pierre Savi, Janine Lorrain, Nicole Duval, Christopher N. Berry, Alain Lalé
Publikováno v:
Europe PubMed Central
SummaryThe antiplatelet and antithrombotic activity of SL65.0472 (7-fluoro-2-oxo-4-[2-[4-(thieno [3,2-c]pyrin-4-yl) piperazin-1-yl]ethyl]-1,2-dihydroquinoline-acetamide), a mixed 5-HT1B/5-HT2A receptor antagonist was investigated on 5HT-induced human
Publikováno v:
Fundamentalclinical pharmacology. 13(2)
The calcium channel blocker diltiazem lowers heart rate in man and this property probably contributes to its clinical effectiveness in ischaemic heart disease and hypertension. This review examines the pharmacological basis of diltiazem's heart rate-