Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Alain Gratton"'
Autor:
Malvin Jefri, Scott Bell, Huashan Peng, Nuwan Hettige, Gilles Maussion, Vincent Soubannier, Hanrong Wu, Heika Silveira, Jean‐Francois Theroux, Luc Moquin, Xin Zhang, Zahia Aouabed, Jeyashree Krishnan, Liam A. O'Leary, Lilit Antonyan, Ying Zhang, Vincent McCarty, Naguib Mechawar, Alain Gratton, Andreas Schuppert, Thomas M. Durcan, Edward A. Fon, Carl Ernst
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 6, Pp 697-712 (2020)
Abstract Making high‐quality dopamine (DA)‐producing cells for basic biological or small molecule screening studies is critical for the development of novel therapeutics for disorders of the ventral midbrain. Currently, many ventral midbrain assa
Externí odkaz:
https://doaj.org/article/3c072113bbe542c08f988aada0c191f2
Autor:
Ian D Blum, Lei Zhu, Luc Moquin, Maia V Kokoeva, Alain Gratton, Bruno Giros, Kai-Florian Storch
Publikováno v:
eLife, Vol 3 (2014)
Ultradian (∼4 hr) rhythms in locomotor activity that do not depend on the master circadian pacemaker in the suprachiasmatic nucleus have been observed across mammalian species, however, the underlying mechanisms driving these rhythms are unknown. W
Externí odkaz:
https://doaj.org/article/981b7ecdc6f342f5baf28bc9d46e0e8c
Autor:
Adolfo Sequeira, Firoza Mamdani, Carl Ernst, Marquis P Vawter, William E Bunney, Veronique Lebel, Sonia Rehal, Tim Klempan, Alain Gratton, Chawki Benkelfat, Guy A Rouleau, Naguib Mechawar, Gustavo Turecki
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6585 (2009)
BACKGROUND:Most studies investigating the neurobiology of depression and suicide have focused on the serotonergic system. While it seems clear that serotonergic alterations play a role in the pathogenesis of these major public health problems, dysfun
Externí odkaz:
https://doaj.org/article/b6b005c52a9b4cb08df09d8db76f0a42
Publikováno v:
Journal of Neurosurgery. 136:1650-1659
OBJECTIVE Alterations in amino acid concentrations are a major contributor to the persistent neurological and behavioral effects induced by concussions and mild traumatic brain injuries (TBIs). Glutamate, the most abundant excitatory amino acid in th
Autor:
Emmanuel Darcq, Dominique Nouel, Giovanni Hernandez, Matthew Pokinko, Polina Ash, Luc Moquin, Alain Gratton, Brigitte Kieffer, Cecilia Flores
Publikováno v:
Psychopharmacology (Berl)
RATIONALE: The Netrin-1/DCC guidance cue pathway is critically involved in the adolescent organization of the mesocorticolimbic dopamine circuitry. Adult mice heterozygous for Dcc show reduced dopamine release in the nucleus accumbens in response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a34e76bfed15846eaf4a7996b26871f
https://europepmc.org/articles/PMC10296775/
https://europepmc.org/articles/PMC10296775/
Autor:
Thad A. Rosenberger, Patrick S. Stumpf, Naguib Mechawar, Carl Ernst, Liam Crapper, Nahum Sonenberg, Luc Moquin, Liam Anuj O’Leary, Jelena Popic, Andreas Schuppert, Xin Zhang, Hyder A. Jinnah, Scott C. Bell, Huashan Peng, Ilse Gantois, Alain Gratton, Michel L. Tremblay, Lilit Antonyan, Hanrong Wu, Diane J. Sutcliffe, Nuwan C. Hettige, Malvin Jefri, Vincent McCarty, Ying Zhang, Ilaria Kolobova
Publikováno v:
Stem Cell Reports
Stem cell reports 16(7), 1749-1762 (2021). doi:10.1016/j.stemcr.2021.06.003
Stem cell reports 16(7), 1749-1762 (2021). doi:10.1016/j.stemcr.2021.06.003
Summary Mutations in HPRT1, a gene encoding a rate-limiting enzyme for purine salvage, cause Lesch-Nyhan disease which is characterized by self-injury and motor impairments. We leveraged stem cell and genetic engineering technologies to model the dis
Autor:
Damian Justo, Marc G. Caron, Luc Moquin, Ornela Kljakic, Xiang Qi Meng, Pedro Rosa Neto, Erika Vigneault, Philibert Duriez, Helena Janickova, Tharick A. Pascoal, Jun-II Kang, Mark P. Brandon, Jacob P. R. Jacobsen, Marco A. M. Prado, Salah El Mestikawy, Vania F. Prado, Philip Gorwood, Jürgen Germann, Alain Gratton, Léonie Runtz, Mathieu Favier, Sanda Raulic, M. Mallar Chakravarty, Christina Antinora, Daniel Gallino, Joman Y. Natsheh, Mohammad M. Herzallah
Publikováno v:
J Clin Invest
Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from restrictive anorexia nervosa have enhanced habit formation compared with healthy controls. Habit form
Autor:
Liam Anuj O’Leary, Naguib Mechawar, Heika Silveira, Jeyashree Krishnan, Carl Ernst, Hanrong Wu, Andreas Schuppert, Ying Zhang, Xin Zhang, Lilit Antonyan, Nuwan C. Hettige, Vincent McCarty, Edward A. Fon, Luc Moquin, Huashan Peng, Zahia Aouabed, Malvin Jefri, Gilles Maussion, Thomas M. Durcan, Vincent Soubannier, Scott C. Bell, Jean-François Théroux, Alain Gratton
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 6, Pp 697-712 (2020)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
Making high‐quality dopamine (DA)‐producing cells for basic biological or small molecule screening studies is critical for the development of novel therapeutics for disorders of the ventral midbrain. Currently, many ventral midbrain assays have l
Autor:
Elisa Guma, Lani Cupo, Weiya Ma, Daniel Gallino, Luc Moquin, Alain Gratton, Gabriel A Devenyi, M Mallar Chakravarty
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 120:110642
BackgroundPrenatal exposure to maternal immune activation (MIA) and chronic adolescent cannabis use are both risk factors for neuropsychiatric disorders. However, exposure to a single risk factor may not result in major mental illness, indicating tha
Autor:
Chloé Guinaudie, Léa C. Perret, Quentin Rainer, Bruno Giros, Alain Gratton, Luc Moquin, Elsa Isingrini
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.12432. ⟨10.1038/s41598-017-12810-9⟩
Scientific Reports, 2017, 7 (1), pp.12432. ⟨10.1038/s41598-017-12810-9⟩
Scientific Reports, Nature Publishing Group, 2017, 7, pp.12432. 〈10.3389/fnana.2014.00155〉
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.12432. ⟨10.1038/s41598-017-12810-9⟩
Scientific Reports, 2017, 7 (1), pp.12432. ⟨10.1038/s41598-017-12810-9⟩
Scientific Reports, Nature Publishing Group, 2017, 7, pp.12432. 〈10.3389/fnana.2014.00155〉
International audience; The type 2 vesicular monoamine transporter (VMAT2), by regulating the storage of monoamines transmitters into synaptic vesicles, has a protective role against their cytoplasmic toxicity. Increasing evidence suggests that impai