Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Alain G. Zeimet"'
Autor:
Heidelinde Fiegl, Simon Schnaiter, Daniel U. Reimer, Katharina Leitner, Petra Nardelli, Irina Tsibulak, Verena Wieser, Katharina Wimmer, Esther Schamschula, Christian Marth, Alain G. Zeimet
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background In high-grade ovarian cancer (HGOC), determination of homologous recombination deficiency (HRD) status is commonly used in routine practice to predict response to platinum-based therapy or poly (ADP-ribose) polymerase inhibitors (
Externí odkaz:
https://doaj.org/article/0bdf725b0b91401bac844e6c5607a2b3
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Somatic mutations within the exonuclease proofreading domain (EDM) of the DNA polymerase Pol ϵ (POLE) gene are increasingly being discovered in ovarian, colorectal, urological, and, especially, endometrial carcinoma (EC), where these are found in up
Externí odkaz:
https://doaj.org/article/51304ad18bba4291a5647a9faba1733a
Autor:
Kai Zimmer, Florian Kocher, Gerold Untergasser, Brigitte Kircher, Arno Amann, Yasmine Baca, Joanne Xiu, W. Micheal Korn, Martin D. Berger, Heinz-Josef Lenz, Alberto Puccini, Elisa Fontana, Anthony F. Shields, John L. Marshall, Michael Hall, Wafik S. El-Deiry, David Hsiehchen, Teresa Macarulla, Josep Tabernero, Renate Pichler, Moh’d Khushman, Upender Manne, Emil Lou, Dominik Wolf, Viktorija Sokolova, Simon Schnaiter, Alain G. Zeimet, Pat Gulhati, Gerlig Widmann, Andreas Seeber
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Polybromo-1 (PBRM1) loss of function mutations are present in a fraction of biliary tract cancers (BTCs). PBRM1, a subunit of the PBAF chromatin-remodeling complex, is involved in DNA damage repair. Herein, we aimed to decipher the molecular
Externí odkaz:
https://doaj.org/article/5241117531c4407f8106f8137c687dda
Autor:
Nicole Heinzl, Katarzyna Koziel, Elisabeth Maritschnegg, Astrid Berger, Elisabeth Pechriggl, Heidi Fiegl, Alain G. Zeimet, Christian Marth, Robert Zeillinger, Nicole Concin
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The tumor suppressor protein p53 is mutated in half of all cancers and has been described to form amyloid-like structures, commonly known from key proteins in neurodegenerative diseases. Still, the clinical relevance of p53 aggregates remains largely
Externí odkaz:
https://doaj.org/article/3ce52af3f7894bba962ddcab3b06bac9
Autor:
Katharina Leitner, Irina Tsibulak, Verena Wieser, Katharina Knoll, Daniel Reimer, Christian Marth, Heidi Fiegl, Alain G. Zeimet
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract SMARCA4 and EZH2 are two functional key players of their respective antagonizing chromatin remodeling complexes SWI/SNF and PRC2. EZH2 inhibitory drugs may abrogate pro-oncogenic features of PRC2 and turn the balance to cell differentiation
Externí odkaz:
https://doaj.org/article/c0f898d9b817455c806a36660ea6347a
Autor:
Uwe Schirmer, Heidi Fiegl, Marco Pfeifer, Alain G. Zeimet, Elisabeth Müller-Holzner, Peter K. Bode, Verena Tischler, Peter Altevogt
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-3 (2018)
Following publication of the original article [1], we have been alerted to errors in Figs. 2 and 8. In Fig. 2B, the GAPDH loading control for Hec1A cells is shown twice in error (in Fig. 2B and Fig. 2C). In Fig. 8, in testis case 1 (first column) the
Externí odkaz:
https://doaj.org/article/af281d7e721840a6b17876bbcfe04196
Autor:
Alain G. Zeimet, Peter Altevogt, Karl Illmensee, Christian Marth, Elisabeth Müller-Holzner, Heidi Fiegl, Nicole Concin, Martin Erdel, Sergej Skvortsov, Svenja Riedle, Michael Hubalek, Daniel Reimer
We describe for the first time a new integral molecular pathway, linking transcription factor E2F3a to epidermal growth factor receptor (EGFR) activation in ovarian cancer cells. Investigations on the role of E2F family members in EGFR-mediated mitog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f74139ae4c62e2e87f718fc7794d3f9e
https://doi.org/10.1158/0008-5472.c.6500129.v1
https://doi.org/10.1158/0008-5472.c.6500129.v1
Autor:
Melanie Ehrlich, Peter W. Laird, Alain G. Zeimet, Elisabeth Müller-Holzner, Christian Marth, Georg Goebel, Heidi Fiegl, Hannes M. Müller, Christian Woods, Guanchao Jiang, Martin Widschwendter
Supplementary Figure 1 from DNA Hypomethylation and Ovarian Cancer Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e458640e206fb4a363cc38e857b68c4
https://doi.org/10.1158/0008-5472.22363238
https://doi.org/10.1158/0008-5472.22363238
Autor:
Alain G. Zeimet, Peter Altevogt, Karl Illmensee, Christian Marth, Elisabeth Müller-Holzner, Heidi Fiegl, Nicole Concin, Martin Erdel, Sergej Skvortsov, Svenja Riedle, Michael Hubalek, Daniel Reimer
Supplementary Figure 2 from E2F3a Is Critically Involved in Epidermal Growth Factor Receptor–Directed Proliferation in Ovarian Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aa92e8dab8c5a7254275996691a028
https://doi.org/10.1158/0008-5472.22382198.v1
https://doi.org/10.1158/0008-5472.22382198.v1
Autor:
Melanie Ehrlich, Peter W. Laird, Alain G. Zeimet, Elisabeth Müller-Holzner, Christian Marth, Georg Goebel, Heidi Fiegl, Hannes M. Müller, Christian Woods, Guanchao Jiang, Martin Widschwendter
Supplementary Table 1 from DNA Hypomethylation and Ovarian Cancer Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2daa895fae5e741729c88448cc40c4f0
https://doi.org/10.1158/0008-5472.22363235
https://doi.org/10.1158/0008-5472.22363235