Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Alain Eychène"'
Autor:
Laure Lecoin, Bowen Dempsey, Alexandra Garancher, Steeve Bourane, Pierre-Louis Ruffault, Marie-Pierre Morin-Surun, Nathalie Rocques, Martyn Goulding, Alain Eychène, Celio Pouponnot, Gilles Fortin, Jean Champagnat
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Apneas are associated with many pathological conditions. Here, the authors show in a mouse model that stabilization of the transcription factor Mafa in brainstem GABAergic neurons may contribute to apnea, by decreasing motor drive to muscles controll
Externí odkaz:
https://doaj.org/article/4e5a7c519af7455ca59539ab8c61aa59
Autor:
Charlène Estrada, Liliana Mirabal-Ortega, Laurence Méry, Florent Dingli, Laetitia Besse, Cedric Messaoudi, Damarys Loew, Celio Pouponnot, Corine Bertolotto, Alain Eychène, Sabine Druillennec
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The MITF transcription factor directly binds to the kinase domain of RAF kinases, including ARAF, BRAF and CRAF in melanoma cells. RAF/MITF complex promotes cytoplasmic accumulation of MITF and thus negatively regulates its transcriptional activity.
Externí odkaz:
https://doaj.org/article/3576fa81d3bb4cd3b9c8215dfe4686e5
Autor:
Morgane Morabito, Magalie Larcher, Florence MG Cavalli, Chloé Foray, Antoine Forget, Liliana Mirabal‐Ortega, Mamy Andrianteranagna, Sabine Druillennec, Alexandra Garancher, Julien Masliah‐Planchon, Sophie Leboucher, Abel Debalkew, Alessandro Raso, Olivier Delattre, Stéphanie Puget, François Doz, Michael D Taylor, Olivier Ayrault, Franck Bourdeaut, Alain Eychène, Celio Pouponnot
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 8, Pp 1-17 (2019)
Abstract Medulloblastoma (MB) is a pediatric tumor of the cerebellum divided into four groups. Group 3 is of bad prognosis and remains poorly characterized. While the current treatment involving surgery, radiotherapy, and chemotherapy often fails, no
Externí odkaz:
https://doaj.org/article/953a146597434510bae487e93455a269
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Epidemiologic analyses have shed light on an association between type 2 diabetes (T2D) and pancreatic ductal adenocarcinoma (PDAC). Recent data also suggest a potential relationship between T2D and insulinoma. Under rare circumstances, type 1 diabete
Externí odkaz:
https://doaj.org/article/33de135cadb24fb8879a30120ded1b67
Autor:
Coralie Dorard, Charlène Estrada, Céline Barbotin, Magalie Larcher, Alexandra Garancher, Jessy Leloup, Friedrich Beermann, Manuela Baccarini, Celio Pouponnot, Lionel Larue, Alain Eychène, Sabine Druillennec
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The melanoma-driver mutations in NRAS and BRAF are mutually exclusive but the contribution of RAF signalling downstream of NRAS remains to be clarified. Here, using mouse models, the authors show specific roles of each member of the RAF family at dif
Externí odkaz:
https://doaj.org/article/3790148bc8624695bd1b7e49449d5c3a
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain
Externí odkaz:
https://doaj.org/article/3580f8ca3fb04b6897b2b04e64ae9c72
Autor:
Agathe Valluet, Sabine Druillennec, Céline Barbotin, Coralie Dorard, Anne H. Monsoro-Burq, Magalie Larcher, Celio Pouponnot, Manuela Baccarini, Lionel Larue, Alain Eychène
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 774-780 (2012)
B-Raf and C-Raf kinases have emerged as critical players in melanoma. However, little is known about their role during development and homeostasis of the melanocyte lineage. Here, we report that knockout of B-raf and C-raf genes in this lineage resul
Externí odkaz:
https://doaj.org/article/87e3b144f5804b57be06e297b7455ca7
Publikováno v:
Journal of Nucleic Acids, Vol 2012 (2012)
Among the 518 protein kinases encoded by the human kinome, several of them act as oncoproteins in human cancers. Like other eukaryotic genes, oncogenes encoding protein kinases are frequently subjected to alternative splicing in coding as well as non
Externí odkaz:
https://doaj.org/article/aff2b95eb716480a86d67465267d798f
Autor:
Agathe Valluet, Isabelle Hmitou, Sabrina Davis, Sabine Druillennec, Magalie Larcher, Serge Laroche, Alain Eychène
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15272 (2010)
The B-raf proto-oncogene exerts essential functions during development and adulthood. It is required for various processes, such as placental development, postnatal nervous system myelination and adult learning and memory. The mouse B-raf gene encode
Externí odkaz:
https://doaj.org/article/54b5eadecc9c4e5e9a8fc7aca6189301
Autor:
Caroline Robert, Nicolas Dumaz, Alain Eychène, Stephan Vagner, Sabine Druillennec, Alexander M. Eggermont, Alain Spatz, Ludovic Lacroix, Lise Boussemart, Nyam Kamsu-Kom, Jocelyne André, Magalie Larcher, Alain Sarasin, David Malka, Jean-Charles Soria, Emilie Hollville, Janine Wechsler, Gorana Tomasic, Bernard Escudier, Christine Mateus, Jean Philippe Arnault
PDF file - 208K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b14c5740a026d255c8835730c846eba
https://doi.org/10.1158/1078-0432.22446047.v1
https://doi.org/10.1158/1078-0432.22446047.v1
