Výsledky vyhledávání - "Alain Deroussent"

Anticancer Properties of Indole Derivatives as IsoCombretastatin A-4 analogues

Autor: Shannon Pecnard, Olivier Provot, Abdallah Hamze, Mouad Alami, Bastien Prost, Jérôme Bignon, Alain Deroussent, Rafael Peláez, Marc Diederich, Laura Gallego-Yerga, Ji Yeon Paik

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2021, 223, pp.113656. ⟨10.1016/j.ejmech.2021.113656⟩
European Journal of Medicinal Chemistry, Elsevier, 2021, 223, pp.113656. ⟨10.1016/j.ejmech.2021.113656⟩

International audience; In this study, a variety of original ligands related to Combretastatin A-4 and isoCombretastatin A-4, able to inhibit the tubulin polymerization into microtubules, was designed, synthesized, and evaluated. Our lead compound 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8335c4f49de3f9d2519b04a2938dbcf1
https://hal.science/hal-03349143

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1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

Autor: Martin Souce, Mouad Alami, Timothée Naret, Olivier Provot, Paloma F. Varela, Athena Kasselouri, Hélène Levaique, Alain Deroussent, Ilhem Khelifi, Jérôme Bignon, Angelo Paci, Benoît Gigant, Joëlle Dubois, Abdallah Hamze

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (4), pp.1902-1916. ⟨10.1021/acs.jmedchem.8b01386⟩
Journal of Medicinal Chemistry, 2019, 62 (4), pp.1902-1916. ⟨10.1021/acs.jmedchem.8b01386⟩

International audience; We report the synthesis and metabolic and biological evaluation of a series of 17 novel heterocyclic derivatives of isocombretastatin-A4 (iso-CA-4) and their structure-activity relationships. Among these derivatives, the most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a2b78671b1af350b21d83a2fd97ebd
https://pubmed.ncbi.nlm.nih.gov/30525602

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Iron Overload Exacerbates Busulfan-Melphalan Toxicity Through a Pharmacodynamic Interaction in Mice

Autor: Lionel Mercier, Alain Deroussent, Fabienne Munier, Clémentine Richard, Dominique Valteau-Couanet, Angelo Paci, Gilles Vassal, Bassim Tou, Jérôme Bouligand, Cedric Orear, Paule Opolon, Romain Kessari, Nicolas Simonnard, Estelle Daudigeos-Dubus

Publikováno v: Pharmaceutical Research. 33:1913-1922

Busulfan-melphalan high-dose chemotherapy followed by autologous stem cell transplantation is an essential consolidation treatment of high-risk neuroblastoma in children. Main treatment limitation is hepatic veno-occlusive disease, the most severe an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1d1d66c93c629301c3c4e7029ff176
https://doi.org/10.1007/s11095-016-1927-z

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Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography–tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study

Autor: Didier Desmaële, Alain Deroussent, Sylvère Durand, Ludivine Le Dret, Angelo Paci, Estelle Daudigeos-Dubus, Charles Skarbek, Adeline Maury, Hubert Chapuis, Patrick Couvreur

Publikováno v: Journal of Chromatography B. 992:30-35

The antitumor drug, ifosfamide (IFO), requires activation by cytochrome P450 (CYP) to form the active metabolite, 4-hydroxyisfosfamide (4-OHIFO), leading to toxic by-products at high dose. In order to overcome these drawbacks, preactivated ifosfamide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a359dc44b7ec38a35eae2971697a20
https://doi.org/10.1016/j.jchromb.2015.04.025

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Poly-isoprenylated ifosfamide analogs: Preactivated antitumor agents as free formulation or nanoassemblies

Autor: Charles Skarbek, Thierry Martens, Alain Deroussent, Eric Le Cam, Didier Desmaële, Catherine Pioche-Durieu, Patrice Renevret, Patrick Couvreur, Sonia Baconnais, Julia Delahousse, Angelo Paci, Michael Rivard

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2017, 532 (2), pp.748-756. ⟨10.1016/j.ijpharm.2017.05.044⟩
International Journal of Pharmaceutics, 2017, 532 (2), pp.748-756. ⟨10.1016/j.ijpharm.2017.05.044⟩

Oxazaphosphorines including cyclophosphamide, trofosfamide and ifosfamide (IFO) belong to the alkylating agent class and are indicated in the treatment of numerous cancers. However, IFO is subject to limiting side-effects in high-dose protocols. To c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37025f7804fb19ab3e942c596c157d8e
https://hal.archives-ouvertes.fr/hal-03065099

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Quantification of dimethyl-ifosfamide and its N-deschloropropylated metabolites in mouse plasma by liquid chromatography–tandem mass spectrometry

Autor: Angelo Paci, Estelle Dubus-Daudigeos, Sonia Martelli, Alain Deroussent, Didier Desmaële, Stéphanie Rodriguez, Atmane Seck, Gilles Vassal

Publikováno v: Journal of Chromatography B. 879:743-750

Among antitumor oxazaphosphorine drugs, the prodrug ifosfamide (IFO) and its analogs require metabolic activation by specific liver cytochrome P450 (CYP) enzymes to become therapeutically active. New 7,9-dimethyl-ifosfamide analogs have shown greater

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295ce360e94a12b5cf5e0f19a494d971
https://doi.org/10.1016/j.jchromb.2011.02.012

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Metabolism of sanguinarine in human and in rat: Characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography–tandem mass spectrometry

Autor: Thierry Cresteil, Micheline Re, Henri Hoellinger, Alain Deroussent

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2010, 52 (3), pp.391-397. ⟨10.1016/j.jpba.2009.09.014⟩

The quaternary benzo[c]phenanthridine alkaloid, sanguinarine (SA), has been detected in the mustard oil contaminated with Argemone mexicana, which produced severe human intoxications during epidemic dropsy in India. Today, SA metabolism in human and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8607eaeba8aad300eff377bbcf2b283f
https://doi.org/10.1016/j.jpba.2009.09.014

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