Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Alain Commercon"'
Publikováno v:
Tetrahedron. 66:8325-8334
Task specific ionic liquids and onium salts have been used as soluble supports for peptide synthesis. These new supports combine easy monitoring, high loading capacities, large scale preparation, and homogeneous kinetics characteristics while keeping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::643129a5b55b2e75b92de558d6308f9a
https://doi.org/10.1016/j.tet.2010.07.016
https://doi.org/10.1016/j.tet.2010.07.016
Publikováno v:
The Journal of Organic Chemistry. 67:8513-8518
It is possible to prepare carbon-based analogues of the Merrifield resin by electrochemical reduction of diazonium salts or oxidation of aryl acetates on high specific surface area carbon felts. These modified felts can undergo further reactions: nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f61112e78da80d91e79fec45262ae26
https://doi.org/10.1021/jo025880+
https://doi.org/10.1021/jo025880+
Autor:
Alain Commercon, Dominique Mouysset, Patricia Perfetti, Serge Mignani, Lucien Stella, Michel Barreau
Publikováno v:
Scopus-Elsevier
Selected imines of methyl glyoxylate act as good partners in the Staudinger cycloaddition reaction with a series of substituted ketenes. The cis stereoselectivity is almost complete with electron-donor substituted ketenes, but the asymmetric inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1abcb0a9c6ee74c7d123052d87ad34
https://doi.org/10.1016/s0040-4020(98)00683-8
https://doi.org/10.1016/s0040-4020(98)00683-8
Autor:
Jean-François Riou, Dorothée Semiond, François Lavelle, Alain Commercon, Loreley Calvet, Cecile Combeau, Marie-Christine Bissery, Herve Bouchard, Patricia Vrignaud, Pascale Lejeune
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 19(11)
Purpose: Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by resistance development. We report here the preclinical characteristics of cabazitaxel (XRP6258), a semisynthetic taxane develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107870d5f6fccd8b723b068b9db44704
https://pubmed.ncbi.nlm.nih.gov/23589177
https://pubmed.ncbi.nlm.nih.gov/23589177
Publikováno v:
Tetrahedron Letters. 37:6327-6330
The semisynthesis of RPR 121056A ( 4 0, a major metabolite of irinotecan (CPT-11, 2 ), is reported starting from SN-38 ( 3 ) and an appropriate side-chain precusor, and using a 2-step sequence. This semisynthesis is based on the 10-O-acylation of SN-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d144c668f765e0b61740b602a6c8d324
https://doi.org/10.1016/0040-4039(96)01387-1
https://doi.org/10.1016/0040-4039(96)01387-1
Autor:
Alain Commercon, Evelyne James-Surcouf, Jean-Dominique Guitton, Bruno Tocque, Nadine Fromage, Jerome Becquart, Marc Duchesne, Yves Lelièvre, Francois-Frederic Clerc
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1779-1784
Constrained analogs of KCVFM, reported thus far as one of the most active peptidic inhibitors of farnesyl transferase, have been synthesized. Replacement of Val-Phe with Val-Tic and (N-Me)Val-Tic led to dramatically more active analogs possessing fav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca92c55c8b7f217242e3c36e475c018a
https://doi.org/10.1016/0960-894x(95)00314-j
https://doi.org/10.1016/0960-894x(95)00314-j
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:809-814
An expedient route for semisynthetic para -modified 3′-phenyl docetaxel analogs is described using the initial regioselective iodination of the oxazolidinecarboxylate 3 . Palladium catalyzed coupling reactions of the iodo intermediate 4 with alkeny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce3bf54f273b8e649567b8e9b4b54dd
https://doi.org/10.1016/0960-894x(95)00118-d
https://doi.org/10.1016/0960-894x(95)00118-d
Autor:
Jean-Pierre Pulicani, Herve Bouchard, Alain Commercon, Jean-Dominique Bourzat, Marc Vuilhorgne
Publikováno v:
Tetrahedron Letters. 35:9713-9716
A new route to semisynthetic 19-nor-7β, 8β-methylene taxoids, such as compound 8 , from the 7-O-trifluoromethanesulfonyl derivative 6 is reported. Evidence for a dissociation of the triflate to form a carbocation at C-7 under the reaction condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d1b87fbcf8f9e55245071054eaa881
https://doi.org/10.1016/0040-4039(94)88367-x
https://doi.org/10.1016/0040-4039(94)88367-x
Publikováno v:
Tetrahedron Letters. 35:9709-9712
The electrochemical reduction of 7α-iodo docetaxel at E-1.3V vs. SCE in methanol in the presence of lithium chloride and hydrochloric acid leads predominantly to 7-deoxy-docetaxel 9. When the electroreduction is conducted at E-1.7V vs. SCE in the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fdffccf46c10d2b05486ed58eb78b65
https://doi.org/10.1016/0040-4039(94)88366-1
https://doi.org/10.1016/0040-4039(94)88366-1
Autor:
Zucco Martine, Bezard Daniel, Jean-Dominique Bourzat, Jean-Pierre Pulicani, Dominique Deprez, Herve Bouchard, Alain Commercon
Publikováno v:
Tetrahedron Letters. 35:9717-9720
A new route to semisynthetic 2-modified docetaxel analogs is described using electrochemical cleavage of the 2-benzoate as the key reaction. Subsequent reacylation at C-2 followed by sequential deprotections afforded the title analogs. Biological res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88755b933111d558969e09e74f12bca6
https://doi.org/10.1016/0040-4039(94)88368-8
https://doi.org/10.1016/0040-4039(94)88368-8