Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alain Chambovey"'
Autor:
Aengus Mac Sweeney, Alain Chambovey, Micha Wicki, Manon Müller, Nadia Artico, Roland Lange, Aleksandar Bijelic, Joscha Breibeck, Annette Rompel
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199639 (2018)
The use of the tellurium-centered Anderson-Evans polyoxotungstate [TeW6O24]6- (TEW) as a crystallization additive has been described. Here, we present the use of TEW as an additive in the crystallization screening of the nucleotide binding domain (NB
Externí odkaz:
https://doaj.org/article/f998f584c5c44a2b990db3842d71b04e
Autor:
Markus Gude, Georg Rueedi, Thomas Pfeifer, Christian Hubschwerlen, Daniel Ritz, Thierry Kimmerlin, L. Jacob, A.-C. Blumstein, Daniel Bur, Alain Chambovey, Lars Prade, Peter Seiler, Philippe Panchaud, Eric A. Ertel, Thierry Bruyère
Publikováno v:
Journal of Medicinal Chemistry. 60:3755-3775
Our strategy to combat resistant bacteria consisted of targeting the GyrB/ParE ATP-binding sites located on bacterial DNA gyrase and topoisomerase IV and not utilized by marketed antibiotics. Screening around the minimal ethyl urea binding motif led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd48a433f27169780b7c54901c1e1ae
https://doi.org/10.1021/acs.jmedchem.6b01834
https://doi.org/10.1021/acs.jmedchem.6b01834
Autor:
Daniel Ritz, Alain Chambovey, Alcibiade Athanasiou, Nadia Ekambaram, Daniela Sabato, Mika Gaertner, Daniel S. Strasser, Michel Enderlin, R. Lange, Pierre Wyss, Christopher Kohl, Wolfgang Keck, Maria Boehme, Gaelle Chapoux, Lars Prade, Jean-Luc Specklin, Peter Seiler, Christine Schmitt, Christian Hubschwerlen, Virginie Sippel, Jean-Philippe Surivet, Eser Ilhan, Andreja Knezevic, Hans H. Locher, Daniel Bur
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(21)
A series of 2-amino-[1,8]-naphthyridine-3-carboxamides (ANCs) with potent inhibition of bacterial NAD+-dependent DNA ligases (LigAs) evolved from a 2,4-diaminopteridine derivative discovered by HTS. The design was guided by several highly resolved X-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28ce0a143d3d58078bbea3e3c8a168b
https://pubmed.ncbi.nlm.nih.gov/23006603
https://pubmed.ncbi.nlm.nih.gov/23006603