Výsledky vyhledávání - "Alain Casanova"

Akademický článek

A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening

Autor: Alain Casanova, Shyan Huey Low, Maxime Québatte, Jaroslaw Sedzicki, Therese Tschon, Maren Ketterer, Kevin Smith, Mario Emmenlauer, Houchaima Ben-Tekaya, Christoph Dehio

Publikováno v: mSphere, Vol 4, Iss 3 (2019)

ABSTRACT Brucella, the agent causing brucellosis, is a major zoonotic pathogen with worldwide distribution. Brucella resides and replicates inside infected host cells in membrane-bound compartments called Brucella-containing vacuoles (BCVs). Followin

Externí odkaz: https://doaj.org/article/0be08e2e45de4b22bdad14ce27a5db8a

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Cost Effectiveness and Budget Impact of Siponimod Compared to Interferon Beta-1a in the Treatment of Adult Patients with Secondary Progressive Multiple Sclerosis with Active Disease in Switzerland

Autor: Matthias Schwenkglenks, Kapil Gudala, Arjun Bhadhuri, Sreelatha Vadapalle, Nadine Schur, Nicholas Adlard, Umakanth Vudumula, Alain Casanova

Publikováno v: Pharmacoeconomics

Objective The study aim was to evaluate the cost effectiveness and budget impact of siponimod compared to interferon beta-1a for adult patients with secondary progressive multiple sclerosis (SPMS) with active disease, from a Swiss health insurance pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73ce8ed8ae94487b8e631103b753cda

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A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening

Autor: Houchaima Ben-Tekaya, Christoph Dehio, Shyan Huey Low, Maxime Québatte, Maren Ketterer, Kevin Smith, Alain Casanova, Mario Emmenlauer, Therese Tschon, Jaroslaw Sedzicki

Publikováno v: mSphere, Vol 4, Iss 3 (2019)
mSphere
mSphere, Vol 4, Iss 3, p e00380-19 (2019)

With >300,000 new cases of human brucellosis annually, Brucella is regarded as one of the most important zoonotic bacterial pathogens worldwide. The agent causing brucellosis resides inside host cells within vacuoles termed Brucella-containing vacuol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f3548add23aeba6f2d29fd6a9b2fa8
https://journals.asm.org/doi/10.1128/mSphere.00380-19

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Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition

Autor: Urs F. Greber, Abhilash Kannan, Simone Eicher, Neha Daga, Wolf-Dietrich Hardt, Jeremy L. Jenkins, Saskia Kreibich, Daniel Andritschke, Alain Casanova, Christoph Dehio, Shyan Huey Low, Mario Emmenlauer, Christian von Mering

Publikováno v: Nucleic Acids Research, 46 (18)
Nucleic Acids Research

Perturbation of gene expression by means of synthetic small interfering RNAs (siRNAs) is a powerful way to uncover gene function. However, siRNA technology suffers from sequence-specific off-target effects and from limitations in knock-down efficienc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b2fa0aa417553b45374609a441e613
https://hdl.handle.net/20.500.11850/302485

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Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens

Autor: Christian von Mering, Andreas Kaufmann, Shyan Huey Low, Mario Emmenlauer, Daniel Andritschke, Ari Helenius, Christoph Dehio, Andrea Franceschini, Neha Daga, Sabrina Dilling, Alain Casanova, Roger Meier, Saskia Kreibich, Lucas Pelkmans, Raquel Conde-Álvarez, Pauli Rämö, Wolf-Dietrich Hardt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Proceedings of the National Academy of Sciences

Systematic genetic perturbation screening in human cells remains technically challenging. Typically, large libraries of chemically synthesized siRNA oligonucleotides are used, each designed to degrade a specific cellular mRNA via the RNA interference

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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Autor: Shyan Huey Low, Mario Emmenlauer, Raquel Conde-Álvarez, Christoph Dehio, Jean-Pierre Gorvel, Alain Casanova, Suzana P. Salcedo

Publikováno v: Journal of Visualized Experiments.

Brucella species are facultative intracellular pathogens that infect animals as their natural hosts. Transmission to humans is most commonly caused by direct contact with infected animals or by ingestion of contaminated food and can lead to severe ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360eed1918419d218610843cda6f2e57
https://doi.org/10.3791/54263

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Simultaneous analysis of large-scale RNAi screens for pathogen entry

Publikováno v: BMC genomics
BMC Genomics, 15
BMC Genomics (15), article 1162 (18 p.). (2014)
BMC Genomics
BMC Genomics, 2014, 15, article 1162 (18 p.). ⟨10.1186/1471-2164/15/1162⟩
BMC Genomics, BioMed Central, 2014, 15, article 1162 (18 p.). ⟨10.1186/1471-2164/15/1162⟩

Background Large-scale RNAi screening has become an important technology for identifying genes involved in biological processes of interest. However, the quality of large-scale RNAi screening is often deteriorated by off-targets effects. In order to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9539cd22b9c8444577acf818184f83f5
https://edoc.unibas.ch/35463/

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