Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alain C Tissot"'
Autor:
Francesca Ros, Sonja Offner, Stefan Klostermann, Irmgard Thorey, Helmut Niersbach, Sebastian Breuer, Grit Zarnt, Stefan Lorenz, Juergen Puels, Basile Siewe, Nicole Schueler, Tajana Dragicevic, Dominique Ostler, Imke Hansen-Wester, Valeria Lifke, Brigitte Kaluza, Klaus Kaluza, Wim van Schooten, Roland Buelow, Alain C Tissot, Josef Platzer
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Transgenic animals incorporating human antibody genes are extremely attractive for drug development because they obviate subsequent antibody humanization procedures required for therapeutic translation. Transgenic platforms have previously been estab
Externí odkaz:
https://doaj.org/article/eb4cfd37c8a244a096d64b9303c73a7f
Autor:
Alain C Tissot, Regina Renhofa, Nicole Schmitz, Indulis Cielens, Edwin Meijerink, Velta Ose, Gary T Jennings, Philippe Saudan, Paul Pumpens, Martin F Bachmann
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9809 (2010)
BACKGROUND: Recombinant proteins and in particular single domains or peptides are often poorly immunogenic unless conjugated to a carrier protein. Virus-like-particles are a very efficient means to confer high immunogenicity to antigens. We report he
Externí odkaz:
https://doaj.org/article/db42a84988b544db8609e97c6ce271ff
Autor:
Szabolcs Éliás, Clemens Wrzodek, Charlotte M. Deane, Alain C. Tissot, Stefan Klostermann, Francesca Ros
Publikováno v:
Frontiers in Bioinformatics, Vol 3 (2024)
Antibodies are generated with great diversity in nature resulting in a set of molecules, each optimized to bind a specific target. Taking advantage of their diversity and specificity, antibodies make up for a large part of recently developed biologic
Externí odkaz:
https://doaj.org/article/82c207e452cf49e4b1f72cfe95d982e4
Autor:
Hendrik Knoetgen, Torsten Schindler, Felix F. Schumacher, Antonia F. Stepan, Alain C. Tissot, Jaclyn I. Wamsteeker Cusulin
Publikováno v:
CHIMIA, Vol 78, Iss 1/2 (2024)
Externí odkaz:
https://doaj.org/article/ddcbb1c975564f9882cbe67f36ba72ac
Autor:
Alain C. Tissot, Ulrich Brinkmann
Publikováno v:
Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases ISBN: 9783319422510
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e21c7b1520f712630939d6adf659f1c7
https://doi.org/10.1007/978-3-319-42252-7_5
https://doi.org/10.1007/978-3-319-42252-7_5
Autor:
Jens A A, Fischer, Axel J, Hueber, Stacy, Wilson, Margarete, Galm, Wolfgang, Baum, Christopher, Kitson, Johannes, Auer, Stefan H, Lorenz, Jörg, Moelleken, Martin, Bader, Alain C, Tissot, Seng-Lai, Tan, Stefan, Seeber, Georg, Schett
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 67(1)
Rheumatoid arthritis therapies that are based on inhibition of a single cytokine, e.g., tumor necrosis factor α (TNFα) or interleukin-6 (IL-6), produce clinically meaningful responses in only about half of the treated patients. This study was under
Autor:
Andreas Plückthun, Markus Tschopp, Carlo Ciatto, Guido Capitani, Markus G. Grütter, Alain C Tissot, Frédéric Pecorari
Publikováno v:
Journal of Molecular Biology. 312:1059-1071
Class I major histocompatibility complex (MHC) molecules, which display intracellularly processed peptides on the cell surface for scanning by T-cell receptors (TCRs), are extraordinarily polymorphic. MHC polymorphism is believed to result from natur
Publikováno v:
Journal of Immunological Methods. 236:147-165
The very low affinity of the T-cell receptor (TCR) for the peptide-major histocompatibility complex (pMHC) has made it very challenging to design assays for testing the functionality of these molecules on small scales, which in turn has severely hamp
Publikováno v:
Journal of Molecular Biology. 285:1831-1843
In a systematic study of the murine T-cell receptor UZ3-4, expressed and refolded from inclusion bodies in Escherichia coli, it was found that functional molecules can be obtained only under a very narrow set of conditions. The refolded T-cell recept
Autor:
Andrew James Godkin, Hans Hengartner, Tim Elliott, Awen Gallimore, Ann Glithero, Andreas Plückthun, Rolf M. Zinkernagel, Alain C Tissot
Publikováno v:
The Journal of Experimental Medicine
This study describes the construction of soluble major histocompatibility complexes consisting of the mouse class I molecule, H-2Db, chemically biotinylated β2 microglobulin and a peptide epitope derived from the glycoprotein (GP; amino acids 33–4