Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alain Boudreault"'
Publikováno v:
The Prostate. 77:866-877
Background Castration-resistant prostate cancer (CRPC) remains incurable and identifying effective treatments continues to present a clinical challenge. Although treatment with enzalutamide, a second generation androgen receptor (AR) antagonist, prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3460fe63c1e686d8889a70364b76c10b
https://doi.org/10.1002/pros.23327
https://doi.org/10.1002/pros.23327
Publikováno v:
The Prostate. 77(8)
Castration-resistant prostate cancer (CRPC) remains incurable and identifying effective treatments continues to present a clinical challenge. Although treatment with enzalutamide, a second generation androgen receptor (AR) antagonist, prolongs surviv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e598064ade2f7f9956cf7b33e8113e92
https://pubmed.ncbi.nlm.nih.gov/28240376
https://pubmed.ncbi.nlm.nih.gov/28240376
Autor:
Wai Chi Ho, Alain Boudreault, Snezana Milutinovic, Kathleen M. Dickson, Philip A. Barker, John W. Gillard, James B. Jaquith, Stephen Morris, Jon P. Durkin, Mathieu J.M. Bertrand
Publikováno v:
Molecular Cell. 30(6):689-700
Summary The inhibitor of apoptosis (IAP) family of proteins enhances cell survival through mechanisms that remain uncertain. In this report, we show that cIAP1 and cIAP2 promote cancer cell survival by functioning as E3 ubiquitin ligases that maintai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050a907688fb9867737ade2b5e741f01
Publikováno v:
Journal of Neurochemistry. 66:2596-2605
Peptidylglycine alpha-amidating enzyme (PAM; EC 1.14.17.3) is responsible for the conversion of peptides with a COOH-terminal glycine into alpha-amidated peptides, a posttranslational modification often required for biological activity and/or increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c716279b4d91ad14c986c6b45eccfc3f
https://doi.org/10.1046/j.1471-4159.1996.66062596.x
https://doi.org/10.1046/j.1471-4159.1996.66062596.x
Autor:
Diane Savaria, Alain Boudreault, Claude Lazure, Nabil G. Seidah, Normand Rondeau, Michel Chrétien, Dany Gauthier
Publikováno v:
Protein Expression and Purification. 14:353-366
A cDNA coding for the murine proprotein convertase-1 (mPC1 also known as mPC3 or mSPC3) was inserted into the Autographa californica nuclear polyhedrosis virus. Following infection of Spodoptera frugiperda cells, the recombinant N-glycosylated protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286d68a0a0c8062e233302e5b5a98989
https://doi.org/10.1006/prep.1998.0964
https://doi.org/10.1006/prep.1998.0964
Autor:
Alain Boudreault, Geoffrey N. Hendy, François Jean, Dany Gauthier, Hugh P.J. Bennett, Claude Lazure, Nabil G. Seidah
Publikováno v:
Journal of Biological Chemistry. 273:8572-8580
The cleavage of parathyroid hormone (PTH) from its precursor proparathyroid hormone (pro-PTH) is accomplished efficiently by the proprotein convertase furin (Hendy, G. N., Bennett, H. P. J., Gibbs, B. F., Lazure, C., Day, R., and Seidah, N. G. (1995)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65415a51c25bd058a2e4df44099471ea
https://doi.org/10.1074/jbc.273.15.8572
https://doi.org/10.1074/jbc.273.15.8572
Autor:
Alain Boudreault, R Day, Iris Lindberg, Weijia Dong, Paul Limperis, Ajoy Basak, Claude Lazure
Publikováno v:
Journal of Biological Chemistry. 273:829-836
Endoproteolytic processing of the 26-kDa protein precursor prodynorphin (proDyn) at paired and single basic residues is most likely carried out by the proprotein convertases (PCs); however, the role of PCs at single basic residues is unclear. In prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4f1dd58f262f5937f291f99bf16dd5e
https://doi.org/10.1074/jbc.273.2.829
https://doi.org/10.1074/jbc.273.2.829
Publikováno v:
Journal of Peptide Science. 1:385-395
Antiserum against an N-terminal sequence of murine prohormone convertase-1 (mPC1) incorporating the sequence immediately following the junction between the putative pro-region and the active enzyme was obtained. This was accomplished using the multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba4c1b87d82a101d6ca10b9cb053e7b
https://doi.org/10.1002/psc.310010606
https://doi.org/10.1002/psc.310010606
Publikováno v:
Journal of Biological Chemistry. 270:19225-19231
The substrate specificities of two human prohormone convertases, furin and PC1, were examined with a series of 7-amino-4-methylcoumarinamide (MCA) containing peptidyl substrates. Using acetyl-Arg-Ser-Lys-Arg-MCA as model, P4 Arg substitution by Lys o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b3cf9b22bffe0bba3552e0bb9f334d
https://doi.org/10.1074/jbc.270.33.19225
https://doi.org/10.1074/jbc.270.33.19225
Autor:
Julie M. Rumble, Clara Hwang, Colin S. Duckett, Stephen Morris, Jon P. Durkin, Alain Boudreault, Karolyn A. Oetjen, Stefanie Galbán, John W. Gillard, James B. Jaquith, Casey W. Wright
Publikováno v:
The Biochemical journal. 417(3)
Deregulated expression of members of the IAP (inhibitor of apoptosis) family has been identified in a wide variety of neoplastic cells, and synthetic IAP antagonists represent a promising novel class of chemotherapeutic agents. Early work focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489b195aac240e10110a51edc683fb21
https://pubmed.ncbi.nlm.nih.gov/18851715
https://pubmed.ncbi.nlm.nih.gov/18851715