Medical research: from way of thinking to way of life

Autor: Alain Beaudet

Publikováno v: McGill Journal of Medicine, Vol 6, Iss 1 (2020)

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Externí odkaz: https://doaj.org/article/da3715d90ab34b6181d8ffff8aa3d266

Morphine priming in rats with chronic inflammation reveals a dichotomy between antihyperalgesic and antinociceptive properties of deltorphin

Autor: M.J. Esdaile, H. Pan, Françoise Mennicken, Catherine M. Cahill, Lakshmi A. Devi, Alain Beaudet, Louis Gendron, Thomas Stroh, Jean-Pierre Vincent, Dajan O'Donnell

Publikováno v: Gendron, L; Esdaile, MJ; Mennicken, F; Pan, H; O’Donnell, D; Vincent, J-P; et al.(2007). Morphine priming in rats with chronic inflammation reveals a dichotomy between antihyperalgesic and antinociceptive properties of deltorphin. Neuroscience, 144(1), 263-274. doi: 10.1016/j.neuroscience.2006.08.077. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5rb9n3mk

We previously showed that prolonged morphine treatment and chronic inflammation both enhanced delta opioid receptor (deltaOR) cell surface density in lumbar spinal cord neurons. Here, we sought to determine whether administration of morphine to rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0ffe0e1c5e82086be011c70a65ea70
https://doi.org/10.1016/j.neuroscience.2006.08.077

Potent Spinal Analgesia Elicited through Stimulation of NTS2 Neurotensin Receptors

Autor: Jean Martinez, Michael J. Esdaile, Alain Beaudet, Amélie Perron, Philippe Sarret, Thomas Stroh

Publikováno v: The Journal of Neuroscience. 25:8188-8196

Intrathecal administration of the neuropeptide neurotensin (NT) was shown previously to exert antinociceptive effects in a variety of acute spinal pain paradigms including hotplate, tail-flick, and writhing tests. In the present study, we sought to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eed9ce261d682d3b23b735d646d439b
https://doi.org/10.1523/jneurosci.0810-05.2005

Prolonged Morphine Treatment Selectively Increases Membrane Recruitment of δ-Opioid Receptors in Mouse Basal Ganglia

Autor: Alain Beaudet, Thomas Stroh, Anna Lisa Lucido, Louis Gendron, Anne Morinville

Publikováno v: Journal of Molecular Neuroscience. 25:207-214

In recent years, we demonstrated that prolonged (48-h) treatment of rats or mice with selective m-opioid receptor ((mu)OR) agonists induced a translocation of delta-opioid receptors ((delta)ORs) from intracellular compartments to neuronal plasma memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927d19d80a4d91e3140bd1d526c1fe8a
https://doi.org/10.1385/jmn:25:3:207

Mu-opioid receptor knockout prevents changes in delta-opioid receptor trafficking induced by chronic inflammatory pain

Autor: Alain Beaudet, Catherine M. Cahill, Brian Collier, Brigitte L. Kieffer, Anne Morinville

Publikováno v: Morinville, A; Cahill, CM; Kieffer, B; Collier, B; & Beaudet, A. (2004). Mu-opioid receptor knockout prevents changes in delta-opioid receptor trafficking induced by chronic inflammatory pain. Pain, 109(3), 266-273. doi: 10.1016/j.pain.2004.01.011. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/47p2m3mm

Previous studies from our laboratory have demonstrated that both chronic inflammatory pain, induced by intraplantar injection of complete Freund's adjuvant (CFA), and prolonged (48 h) stimulation of mu-opioid receptors (muOR) by systemic administrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b74d837515d08a56a3c40cb7431bfb
https://doi.org/10.1016/j.pain.2004.01.011