Výsledky vyhledávání - "Alain Badorc"

N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist

Publikováno v: Journal of medicinal chemistry. 57(17)

In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b64860ee2ed44163c467111c8fa67
https://pubmed.ncbi.nlm.nih.gov/25075638

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New Orally Active Non-Peptide Fibrinogen Receptor (GpIIb-IIIa) Antagonists: Identification of Ethyl 3-[N-[4-[4-[Amino[(ethoxycarbonyl)imino]methyl]phenyl]- 1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]piperid-4-yl]amino]propionate (SR 121787) as a Potent and Long-Acting Antithrombotic Agent

Autor: Jean-Marc Herbert, Maurice Petitou, Marie-Francoise Bordes, Alain Badorc, Jean-Pierre Maffrand, Lalé A, de Cointet P, Andre Bernat, Pierre Savi

Publikováno v: Journal of Medicinal Chemistry. 40:3393-3401

The platelet fibrinogen receptor GpIIb-IIIa is curently considered a target of choice for drugs used in the prevention and treatment of thrombosis. Ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl)imino]met...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04845bef979001a03632e1287bff817d
https://doi.org/10.1021/jm970240y

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New synthesis of 5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine

Autor: Jean-Marie Pereillo, Alain Badorc, Daniel Frehel, Jean-Pierre Maffrand

Publikováno v: Journal of Heterocyclic Chemistry. 22:1011-1016

This paper describes two new access routes to 5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine from 2-(2-thienyl)ethylamine or its N-(2-chlorobenzyl) derivative. One of these two syntheses involves a new ring expansion from a 6,7-dihydro[3,2-c]pyridinium d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39a13580893894ffc3bdec0a82668f2f
https://doi.org/10.1002/jhet.5570220416

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