Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alain Ajamian"'
Publikováno v:
ACS Omega, Vol 9, Iss 11, Pp 13217-13226 (2024)
Externí odkaz:
https://doaj.org/article/3e54a96aa7134083bd34c82b52aac1c0
Autor:
Jeffrey M. Besterman, Amal Wahhab, Alain Ajamian, Martin Allan, Sylvain Lefebvre, Alina Nicolescu, Robert Deziel, Eric Therrien, Jacques Rodrigue, Sukhdev Manku, Jubrail Rahil, Andrea J. Petschner, Zuomei Li, Marielle Fournel, James Wang, Tim Guo, Natalie Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1866-1870
We have recently reported on a novel class of histone deacetylase (HDAC) inhibitors bearing a sulfamide group as the zinc-binding unit. Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their struc
Autor:
James L. Gleason, Alain Ajamian
Publikováno v:
Angewandte Chemie International Edition. 43:3754-3760
Advances in metal catalysis have revolutionized organic synthesis, with the scope of metal-catalyzed reactions now covering nearly all areas of carbon-carbon, carbon-hydrogen, and carbon-heteroatom bond formation. For years, the goal was to develop c
Autor:
Alain Ajamian, James L. Gleason
Publikováno v:
Angewandte Chemie. 116:3842-3848
Die Fortschritte in der Metallkatalyse haben die organische Synthese revolutioniert: Die Anwendung metallkatalysierter Reaktionen erstreckt sich nun uber fast alle Bereiche der C-C-, C-H- und C-Heteroatom-Bindungsknupfung. Viele Jahre war die selekti
Publikováno v:
Journal of Cheminformatics
Upon ligand binding, solvent molecules around the binding pocket and the ligand become displaced or rearranged. These desolvation energies can be a significant portion of the total binding energy, and thus represent opportunities for ligand design. C
Autor:
James L. Gleason, Alain Ajamian
Publikováno v:
Organic Letters. 3:4161-4164
Allyl propargyl ethers undergo cobalt-mediated cycloisomerization reactions to form dihydrofurans in good yield and with excellent diastereoselectivity. The reaction works with a range of substrates, and its utility in synthesis is exemplified by the
Autor:
Alain Ajamian, James L. Gleason
Publikováno v:
Organic Letters. 5:2409-2411
[reaction: see text] 1,6-Enynes and allyl propargyl ethers undergo a cobalt-catalyzed formal 5-endo-dig cyclization to form vinyl cyclopentenes and dihydrofurans, respectively. The use of equimolar amounts of dicobalt octacarbonyl and trimethyl phosp
Autor:
Alain Ajamian, James L. Gleason
Publikováno v:
ChemInform. 33
Allyl propargyl ethers undergo cobalt-mediated cycloisomerization reactions to form dihydrofurans in good yield and with excellent diastereoselectivity. The reaction works with a range of substrates, and its utility in synthesis is exemplified by the
Autor:
Zuomei Li, Alain Ajamian, Sukhdev Manku, Silvana Leit, Marielle Fournel, Martin Allan, Jeffrey M. Besterman, Yves Andre Chantigny, Amal Wahhab, Eric Therrien, Theresa P. Yan, Sylvain Lefebvre, Jubrail Rahil, Andrea J. Petschner, Alina Nicolescu, David Smil, Robert Deziel, Aihua Lu, Samuel Montcalm, Natalie Nguyen
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(2)
The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and selectivity of these inhibitors were influenced both by the nature of the scaffold, and the capping group. Linear long-chain-based analogs were primarily HDAC6-se
Publikováno v:
Journal of Cheminformatics
Pharmacophore models play an essential role in drug discovery. Generating pharmacophore models which encode accurate molecular recognition features are highly dependent on properly defined annotations. Simplistic or ill-defined pharmacophore annotati